Category: 51463-17-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51463-17-3,6-Chloroisoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.,51463-17-3

To a mixture of 6-chloroisoquinolin-3-ol (3.3 g, 18.4 mmol) and pyridine (7.43 ml, 91.9 mmol) in dichloromethane at 0C was added triflic anhydride (1.0 M in dichloromethane, 18.4 ml, 18.4 mmol) slowly via syringe. The reaction was allowed to warm to room temperature and stirred for 3 h then most of the solvent was removed by rotary evaporation. The residue was diluted ether and washed water (3x), 1 N HC1, and brine. The organics were dried over MgS04 and concentrated to afford 2.1 g (37%) of trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester as a green crystalline solid.

As the paragraph descriping shows that 51463-17-3 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALAM, Muzaffar; HAWLEY, Ronald Charles; LYNCH, Stephen M.; NARAYANAN, Arjun; WO2014/86701; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51463-17-3,6-Chloroisoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.,51463-17-3

To a mixture of 6-chloroisoquinolin-3-ol (3.3 g, 18.4 mmol) and pyridine (7.43 ml, 91.9 mmol) in dichloromethane at 0C was added triflic anhydride (1.0 M in dichloromethane, 18.4 ml, 18.4 mmol) slowly via syringe. The reaction was allowed to warm to room temperature and stirred for 3 h then most of the solvent was removed by rotary evaporation. The residue was diluted ether and washed water (3x), 1 N HC1, and brine. The organics were dried over MgS04 and concentrated to afford 2.1 g (37%) of trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester as a green crystalline solid.

As the paragraph descriping shows that 51463-17-3 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALAM, Muzaffar; HAWLEY, Ronald Charles; LYNCH, Stephen M.; NARAYANAN, Arjun; WO2014/86701; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51463-17-3,6-Chloroisoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.,51463-17-3

To a mixture of 6-chloroisoquinolin-3-ol (3.3 g, 18.4 mmol) and pyridine (7.43 ml, 91.9 mmol) in dichloromethane at 0C was added triflic anhydride (1.0 M in dichloromethane, 18.4 ml, 18.4 mmol) slowly via syringe. The reaction was allowed to warm to room temperature and stirred for 3 h then most of the solvent was removed by rotary evaporation. The residue was diluted ether and washed water (3x), 1 N HC1, and brine. The organics were dried over MgS04 and concentrated to afford 2.1 g (37%) of trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester as a green crystalline solid.

As the paragraph descriping shows that 51463-17-3 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALAM, Muzaffar; HAWLEY, Ronald Charles; LYNCH, Stephen M.; NARAYANAN, Arjun; WO2014/86701; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51463-17-3,6-Chloroisoquinolin-3(2H)-one,as a common compound, the synthetic route is as follows.,51463-17-3

To a mixture of 6-chloroisoquinolin-3-ol (3.3 g, 18.4 mmol) and pyridine (7.43 ml, 91.9 mmol) in dichloromethane at 0C was added triflic anhydride (1.0 M in dichloromethane, 18.4 ml, 18.4 mmol) slowly via syringe. The reaction was allowed to warm to room temperature and stirred for 3 h then most of the solvent was removed by rotary evaporation. The residue was diluted ether and washed water (3x), 1 N HC1, and brine. The organics were dried over MgS04 and concentrated to afford 2.1 g (37%) of trifluoro-methanesulfonic acid 6-chloro-isoquinolin-3-yl ester as a green crystalline solid.

As the paragraph descriping shows that 51463-17-3 is playing an increasingly important role.

Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ALAM, Muzaffar; HAWLEY, Ronald Charles; LYNCH, Stephen M.; NARAYANAN, Arjun; WO2014/86701; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem