Category: 52986-70-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.

52986-70-6, b) ISOQUINOLIN-6-OL Heat a mixture of 6-methoxy-isoquinoline (2.1 g, 13.2 mmol) and pyridine hydrochloride (30 g) in a heavy walled screw cap sealed tube at 160C overnight. Cool to room temperature, add water and concentrated ammonium hydroxide to bring the pH of the mixture to 10-11, extract with ethyl acetate (4 times), wash the combined organic extracts with water (4 times), and concentrate under reduced pressure. Purification by medium pressure liquid chromatography eluting with 0-3% of 2N NH3/MeOH in dichloromethane afford the title compound (520 mg, 27%) : 8H (DMSO-d6,400 MHz): 7.09 (s, 1H), 7.19 (dd, 1H, J=9,2 Hz), 7.56 (d, 1H, J = 6 Hz), 7.94 (d, 1H, J = 9 HZ), 8.29 (d, 1H, J = 6 Hz), 9.05 (s, 1H), 10.36 (s, 1H).

As the paragraph descriping shows that 52986-70-6 is playing an increasingly important role.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2004/43904; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.

52986-70-6, General procedure: A flame-dried and nitrogen flushed 50 mL Schlenk flask, equipped with a magnetic stirringbar, was charged with the appropriate isoquinoline 7a-c (prepared according to lit. [1,2])(2.00 mmol) in dry THF (10 mL). TMPMgClLiCl (1.0 M in THF/toluene; 3.00 mL, 3.00 mmol)was added to this solution dropwise over 2 min. The reaction mixture was stirred at roomtemperature for 4 h. After cooling to 0 C, a solution of iodine (0.761 g, 3.00 mmol) in dryTHF (3 mL) was added dropwise to the reaction mixture. The cooling bath was removed andthe mixture was stirred at room temperature for 1 h. Then the mixture was quenched withsatd. aqueous NH4Cl solution (4 mL) and satd. aqueous Na2S2O3 solution (4 mL). Afterextraction with dichloromethane (3 ¡Á 20 mL), the combined organic layers were dried withNa2SO4, and concentrated under reduced pressure. The residue was purified by flashcolumn chromatography (ethyl acetate/dichloromethane = 1:5).

52986-70-6 6-Methoxyisoquinoline 11040978, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Melzer, Benedikt C.; Bracher, Franz; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1564 – 1571;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.

(c) 6-Methoxyisoquinoline (16 g, 0.1M) and 48% aqueous HBr (600 ml) were refluxed together for 6 hours and the mixture was then evaporated to dryness in vacuo. The residue was dissolved in H2 O and basified with solid Na2 CO3. The resulting precipitated solid was filtered off and recrystallized from isopropanol to give 6-hydroxyisoquinoline (12 g, 82%), m.p. 218-20 C. (lit.* 220 C.).

The synthetic route of 52986-70-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SmithKline & French Laboratories, Ltd.; US4812573; (1989); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem