Category: 660830-62-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.660830-62-6,Ethyl 7-bromoisoquinoline-3-carboxylate,as a common compound, the synthetic route is as follows.,660830-62-6

To a stirred solution of ethyl 7-bromoisoquinoline-3-carboxylate (1 .2 g, 4.28 mmol, 1 .0 equiv) in MeOH: THF: H20 (2:2:1 ) (35 mL) was added LiOH monohydrate (0.9 g, 21 .42 mmol, 5 equiv) at 0C and stirring was continued at room temperature for 0.5 h. The reaction mixture was evaporated and quenched with 1 N HCI. The reaction mixture was extracted with 5% MeOH in DCM (3 x 50 mL), and the combined organics was dried over sodium sulphate, filtered and concentrated to give 7-bromoisoquinoline-3-carboxylic acid (1 .0 g, crude) as an off-white solid. LCMS (ES) m/z = 252.0, 254.0 [M+H]+. 1H NMR (400 MHz, DMSO-de) delta ppm 8.01 (dd, J=2.0, 8.8 Hz, 1 H), 8.16 ((d, J=8.8 Hz, 1 H), 8.54 (s, 1 H), 8.64 (s, 1 H), 9.37 (s, 1 H), 13.16 (br. s., 1 H).

660830-62-6 Ethyl 7-bromoisoquinoline-3-carboxylate 69083434, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey; KETHIRI, Raghava Reddy; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (162 pag.)WO2018/15879; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

660830-62-6, Ethyl 7-bromoisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,660830-62-6

To a solution of ethyl 7-bromoisoquinoline-3-carboxylate (0.46 g, 1.6 mmol) in dichloromethane (10 mL) at 0 C was added 3-chlorobenzoperoxoic acid (0.55 g, 2.4 mmol) in one portion. The resulting solution was stirred at room temperature for 22 h, quenched with saturated aqueous NaHCO3 (20 mL) and extracted with dichloromethane (3 x 40 mL). The combined extracts were dried over Na2504, filtered and concentrated in vacuo todryness. The residue was loaded onto an Isco solid load cartridge and purified by flash chromatography on Si02 (60-95% EtOAc/hexanes) to give 7-bromo-3- (ethoxycarbonyl)isoquinoline 2-oxide (0.34 g, 1.1 mmol, 70% yield) as a white solid. MS (ESI) m/z: 297.9 (M+H).

As the paragraph descriping shows that 660830-62-6 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; CARPENTER, Joseph E.; BROEKEMA, Matthias; FENG, Jianxin; LIU, Chunjian C.; WANG, Wei; WANG, Ying; (244 pag.)WO2019/89670; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

660830-62-6, Ethyl 7-bromoisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,660830-62-6

Production Example 46-3 Ethyl 7-[4-[(4-fluorobenzyl)oxy]-2-oxopyridin-1(2H)-yl]isoquinoline-3-carboxylate At room temperature, 4-(fluorobenzyl)oxy-2(1H)-pyridone (337 mg), potassium carbonate (639 mg) and copper(I) iodide (322 mg) were successively added to a DMF solution (15 mL) of the compound (431 mg) obtained in Production Example 46-2. The reaction liquid was stirred at 100 C. for 12 hours, then poured into diluted ammonia water. The formed precipitate was collected by filtration, the solid was washed with water, then dissolved in chloroform. The organic layer was washed with saturated saline water, then dried with anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, then the residue was dissolved in ethanol (60 mL), and concentrated sulfuric acid (3 mL) was added and stirred with heating under reflux for 12 hours. The reaction liquid was poured into aqueous saturated sodium hydrogencarbonate solution, and extracted with ethyl acetate. The organic layer was washed with saturated saline water, then dried with anhydrous sodium sulfate. The solvent was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (methanol:chloroform=1:200) to obtain the entitled compound (109 mg).

As the paragraph descriping shows that 660830-62-6 is playing an increasingly important role.

Reference£º
Patent; Sakuraba, Shunji; Kameda, Minoru; Kishino, Hiroyuki; Haga, Yuji; Otake, Norikazu; Moriya, Minoru; US2009/264426; (2009); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem