With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.660830-62-6,Ethyl 7-bromoisoquinoline-3-carboxylate,as a common compound, the synthetic route is as follows.,660830-62-6
To a stirred solution of ethyl 7-bromoisoquinoline-3-carboxylate (1 .2 g, 4.28 mmol, 1 .0 equiv) in MeOH: THF: H20 (2:2:1 ) (35 mL) was added LiOH monohydrate (0.9 g, 21 .42 mmol, 5 equiv) at 0C and stirring was continued at room temperature for 0.5 h. The reaction mixture was evaporated and quenched with 1 N HCI. The reaction mixture was extracted with 5% MeOH in DCM (3 x 50 mL), and the combined organics was dried over sodium sulphate, filtered and concentrated to give 7-bromoisoquinoline-3-carboxylic acid (1 .0 g, crude) as an off-white solid. LCMS (ES) m/z = 252.0, 254.0 [M+H]+. 1H NMR (400 MHz, DMSO-de) delta ppm 8.01 (dd, J=2.0, 8.8 Hz, 1 H), 8.16 ((d, J=8.8 Hz, 1 H), 8.54 (s, 1 H), 8.64 (s, 1 H), 9.37 (s, 1 H), 13.16 (br. s., 1 H).
660830-62-6 Ethyl 7-bromoisoquinoline-3-carboxylate 69083434, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; AXTEN, Jeffrey; KETHIRI, Raghava Reddy; KRISTAM, Rajendra; VENKATESHAPPA, Chandregowda; (162 pag.)WO2018/15879; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem