Synthesis of isoquinolines from indenes was written by Miller, R. Bryan;Frincke, James M.. And the article was included in Journal of Organic Chemistry in 1980.Formula: C9H6IN This article mentions the following:
A general procedure for the preparation of Me, di-Me, NO2, Br, iodo, and di-MeO-substituted isoquinolines from the appropriately substituted indenes is described. Ozonolysis of the indenes followed by reductive workup gives intermediate homophthalaldehydes, which are treated with NH4OH to give the isoquinolines. This “one-pot”, three-step reaction sequence was applied to the formation of all of the mono-C-methyl-substituted isoquinolines in a regiospecific manner. The procedure is applicable to both electron-withdrawing and electron-donating substituents on the indene system. In this manner the 6- and 7-nitro-, -bromo-, and -iodoisoquinolines were prepared In the experiment, the researchers used many compounds, for example, 6-Iodoisoquinoline (cas: 75476-84-5Formula: C9H6IN).
6-Iodoisoquinoline (cas: 75476-84-5) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Formula: C9H6IN
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem