Category: 86-51-1

Xu, Haiwei published the artcileDesign and synthesis of novel butenolide derivatives and inducing apoptosis in gastric cancer cells, Computed Properties of 86-51-1, the main research area is uncinine preparation antitumor gastric cancer; morpholinomethylbutenolide preparation diastereoselective antitumor apoptosis structure activity.

A new method of preparation for natural product uncinine was reported. According to the method, a series of novel butenolides derivatives I (X = O, CH2, NCH3), II (R = Me, OMe, n = 0, 1) and III [R1 = phenylmethylidene, thiophen-2-ylmethylidene, [3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]methylidene, etc.] were designed and synthesized based on the natural product Uncinine. Most of the synthetic compounds showed significant antiproliferation activity against MGC-803. Among of them, III [R1 = (4-tert-butylphenyl)methylidene] (IV) showed a potent anticancer effect with IC50 of 2.9μmol/L in gastric cancer cell MGC803 and showed good selectivity to gastric cancer cells MGC803, HGC27, SGC7901 and less cytotoxicity in a normal gastric epithelial cell line (GES1). The research on the mol. level suggests that the mechanism of compound IV inducing apoptosis in gastric cancer cells is partially dependent on activation of caspase-9/3.

Youji Huaxue published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Computed Properties of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jha, Anand Mohan published the artcileOligosaccharides as green catalyst for one-pot multicomponent synthesis of spirooxindole derivatives in water, Formula: C9H10O3, the main research area is isatin isatoic anhydride amine cyclodextrin catalyst multicomponent reaction; spiroindolequinazoline preparation green chem; amine benzaldehyde isatoic anhydride cyclodextrin catalyst multicomponent reaction; phenyl quinazolinone preparation green chem.

A one pot synthetic methodol. was developed towards multicomponent synthesis of spiro[indoline-3,2′- quinazoline]-2,4′(3’H)-dione from isatoic anhydride, isatin and primary amines in aqueous medium via supramol. catalysis. An untapped potential of β-Cyclodextrin to mediate multicomponent reactions in aqueous medium was revealed. Developed protocol was further verified by extrapolating the synthetic protocol using different isatin derivatives and amine analogs. In other synthetic scheme, some compounds were synthesized by reaction of various substituted benzaldehydes, Isatoic anhydride and primary amines. Synthesized library of compounds were further characterized using various spectroscopic techniques. During all the synthetic process, the catalytic efficiency of cyclodextrin was exploited. Efficiency of all the three forms of cyclodextrins were tested to find the best reaction for synthesis of spiro compounds The usefulness of β-cyclodextrin was proved by showing its reusability. The essential role of β-cyclodextrin in the synthetic methodol. was further proved by doing the control experiments which showed that no product was formed in the absence of catalyst. The attachment of reactant mol. was also proved by doing 1H NMR of reaction mixture at different time interval in D2O. On the basis of observation, a plausible mechanistic pathway of reaction was proposed. Other two forms of cyclodextrins were also eliminated on the ground of their insuitability in the formation of desired product. Catalyst recovery procedure was established and was used without any significant loss of catalytic activity upto 5 times.

International Journal of Life Science and Pharma Research published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shambhavi, Chikkabagilu Nagaraju published the artcileRh(III)-Catalyzed Enone Carbonyl/Ketone-Directed Aerobic C-H Olefination of Aromatics with Unactivated Olefins, Product Details of C9H10O3, the main research area is chalcone alkene rhodium catalyst regioselective diastereoselective olefination; alkenyl chalcone preparation.

A Rh(III)-catalyzed weak enone carbonyl/ketone-assisted aerobic oxidative C-H olefination of aromatics with unactivated alkenes was developed. This protocol involves cross-dehydrogenative Heck-type olefination reaction of various substituted biol. relevant chalcones and aromatic ketones such as acetophenones and chromones with various functionalized unactivated olefins in moderate to good yields. Further, ortho-alkylation of chalcones with norbornene was also demonstrated. A possible reaction mechanism involving weak chelation-assisted C-H activation/insertion/β-hydride elimination was proposed and supported by the deuterium labeling studies.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Suresh published the artcileMicrowave-Assisted Multicomponent Reaction: A Green and Catalyst-Free Method for the Synthesis of Poly-Functionalized 1,4-Dihydropyridines, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde aniline malononitrile dimethylacetylenedicarboxylate multicomponent reaction microwave irradiation; dimethyl phenyl phenyldihydropyridinedicarboxylate preparation green chem.

A facile and an efficient procedure for the synthesis of poly-substituted 1,4-dihydropyridine derivatives under catalyst-free conditions was established by a one-pot multi-component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach were: simple operation, non-toxic, short reaction time (< 5 min), excellent yields (93-98%), no column chromatog., clean reaction profile and environmentally friendly reaction. ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Upadhyay, Rahul published the artcileV2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls, Synthetic Route of 86-51-1, the main research area is aldehyde ketone preparation green chem; alc alkylbenzene styrene selective oxidation vanadia titania catalyst.

The versatile application of different functional groups such as alcs. (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions has been reported. The method was successfully applied for the alc. oxidation, oxidative scission of styrenes, and benzylic C-H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30% aqueous), TBHP (70% aqueous), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol.

ChemCatChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Qinfang published the artcileConstruct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is indenooxepine preparation; malononitrile aldehyde crotonate derived sulfur ylide annulation; cyclopropyl acrylate diastereoselective preparation; arylideneindenedione aldehyde crotonate derived sulfur ylide annulation.

For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione was reported using Na2CO3 as the base. This protocol was advantageous as it does not require prior preparation of arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione substrates, due to the independent participation of the base in the two reactions. This mild, operationally multicomponent process could be employed for the transformation of a wide variety of com. available aldehydes into the corresponding indeno[1,2-b]oxepines I [R = H, 4-CNC6H4, 2-OMeC6H4, etc.; R1 = Me, Et] or cyclopropyl acrylate core II in moderate to excellent yields under mild conditions.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazanov, Daniil R. published the artcile2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation, Application In Synthesis of 86-51-1, the main research area is design synthesis biol evaluation trisalkoxyarylimidazoline p53 MDM2 interaction inhibitor; Anticancer; Fragmentary approach; Imidazolines; Nutlin analogues; Synthetic design.

Imidazoline-based small mol. inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents in cis-imidazoline core for biol. activity of nutlin family compounds Although the necessity of the substituents in the Ph rings of cis-imidazoline has been shown, there are no studies in which the replacements of a halogen by other substituents have been investigated. A series of simple cis-imidazoline derivatives containing halogen, hydroxy and alkoxy-substituents were synthesized. The biol. activity of the compounds was studied using assays of cytotoxicity (MTT) and p53 level. It was found that the hydroxyl-derivatives were not cytotoxic whereas the alkoxy analogs were the same or more active as halogen-substituted compounds in cell viability test. The synthesized alkoxy derivatives induced an increase of p53 level and did not promote necrotic cell death in the concentration up to 40 μM.

Bioorganic & Medicinal Chemistry Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mohamadpour, Farzaneh published the artcileMethylene blue as a photo-redox catalyst: the development synthesis of tetrahydrobenzo[b]pyran scaffolds via a single-electron transfer/energy transfer, Synthetic Route of 86-51-1, the main research area is tetrahydrobenzopyran preparation green chem methylene blue photoredox catalyst; aldehyde malononitrile dimedone tandem reaction single electron transfer energy; aqueous solvent; methylene blue (MB+); photo-redox catalyst; photochemical synthesis; renewable energy source; tetrahydrobenzo[b]pyran scaffolds.

In a green tandem reaction using aldehyde derivatives, malononitrile, and dimedone, a radical tandem Knoevenagel-Michael cyclocondensation reaction of tetrahydrobenzo[b] pyran scaffolds was developed. Using visible light as a sustainable energy source, methylene blue (MB+)-derived photo-excited state functions were employed in an aqueous solution as single-electron transfer (SET) and energy transfer catalysts. The range of yields is quite uniform (81-98%, average 92.18%), and the range of reaction time is very fast (2-7 min, average 3.7 min), and the point mentioned in the discussion is that the procedure tolerates a range of donating and withdrawing groups, while still giving very excellent yields. The reaction is fairly insensitive to the nature of the substituents. Research conducted in this project aims to develop a non-metallic cationic dye that is both inexpensive and widely available for more widespread use. In addition to energy efficiency and environmental friendliness, methylene blue also offers an excellent atom economy, time-saving features, and ease of use. As a result, a wide range of long-term chem. and environmental properties can be obtained. The turnover number and turnover frequency of tetrahydrobenzo[b]pyran scaffolds have been computed. Surprisingly, gram-scale cyclization is a possibility, implying that the technol. may be applied in industries.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dabiri, Minoo published the artcilePalladium Catalyzed Cross-Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2-b]quinazolinone, Name: 2,3-Dimethoxybenzaldehyde, the main research area is hydroxyisoindoloquinazolinone preparation palladium catalyzed cross dehydrogenative coupling annulation; cross dehydrogenative coupling cyclization arylquinazolinone aldehyde TBHP oxidant.

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramol. cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Addnl., the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-Bu hydroperoxide (TBHP) as the oxidant in good yield.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sheng, Min published the artcileSingle-Crystal Cobalt Phosphide Nanorods as a High-Performance Catalyst for Reductive Amination of Carbonyl Compounds, Related Products of isoquinoline, the main research area is cobalt phosphide nanorod preparation surface structure; aldehyde ammonia cobalt phosphide nanocatalyst reductive amination green chem; ketone ammonium acetate cobalt phosphide reductive amination green chem; primary amine preparation.

Herein, the successful synthesis of single-crystal cobalt phosphide nanorods (Co2P NRs) containing coordinatively unsaturated Co-Co active sites, which serve as a new class of air-stable, highly active, and reusable heterogeneous catalysts for the reductive amination of carbonyl compounds was reported. The Co2P NR catalyst showed high activity for the transformation of a broad range of carbonyl compounds to their corresponding primary amines using an aqueous ammonia solution or ammonium acetate as a green amination reagent at 1 bar of H2 pressure; these conditions were far milder than previously reported. The air stability and high activity of the Co2P NRs was noteworthy, as conventional Co catalysts were air-sensitive (pyrophorous) and show no activity for this transformation under mild conditions. P-alloying was therefore of considerable importance for nanoengineering air-stable and highly active non-noble-metal catalysts for organic synthesis.

JACS Au published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem