Category: 87087-20-5

87087-20-5, Name is 7-Isoquinolinecarboxaldehyde, belongs to isoquinoline compound, is a common compound. Application In Synthesis of 7-IsoquinolinecarboxaldehydeIn an article, once mentioned the new application about 87087-20-5.

Choline kinase alpha (ChoKalpha) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis. Since several inhibitors of ChoKalpha display antiproliferative activity in both cellular and animal models, this novel oncogene has recently gained interest as a promising small molecule target for cancer therapy. Here we summarize our efforts to further validate ChoKalpha as an oncogenic target and explore the activity of novel small molecule inhibitors of ChoKalpha. Starting from weakly binding fragments, we describe a structure based lead discovery approach, which resulted in novel highly potent inhibitors of ChoKalpha. In cancer cell lines, our lead compounds exhibit a dose-dependent decrease of phosphocholine, inhibition of cell growth, and induction of apoptosis at low micromolar concentrations. The druglike lead series presented here is optimizable for improvements in cellular potency, drug target residence time, and pharmacokinetic parameters. These inhibitors may be utilized not only to further validate ChoKalpha as antioncogenic target but also as novel chemical matter that may lead to antitumor agents that specifically interfere with cancer cell metabolism.

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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. category: isoquinoline, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 87087-20-5

Choline kinase alpha (ChoKalpha) is an enzyme involved in the synthesis of phospholipids and thereby plays key roles in regulation of cell proliferation, oncogenic transformation, and human carcinogenesis. Since several inhibitors of ChoKalpha display antiproliferative activity in both cellular and animal models, this novel oncogene has recently gained interest as a promising small molecule target for cancer therapy. Here we summarize our efforts to further validate ChoKalpha as an oncogenic target and explore the activity of novel small molecule inhibitors of ChoKalpha. Starting from weakly binding fragments, we describe a structure based lead discovery approach, which resulted in novel highly potent inhibitors of ChoKalpha. In cancer cell lines, our lead compounds exhibit a dose-dependent decrease of phosphocholine, inhibition of cell growth, and induction of apoptosis at low micromolar concentrations. The druglike lead series presented here is optimizable for improvements in cellular potency, drug target residence time, and pharmacokinetic parameters. These inhibitors may be utilized not only to further validate ChoKalpha as antioncogenic target but also as novel chemical matter that may lead to antitumor agents that specifically interfere with cancer cell metabolism.

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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H931N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of 7-Isoquinolinecarboxaldehyde, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 87087-20-5, Name is 7-Isoquinolinecarboxaldehyde, molecular formula is C10H7NO

IMIDAZOTRIAZINONE COMPOUNDS

The present invention provides imidazotriazinone compounds which are inhibitors of phosphodiesterase 9 and pharmaceutically acceptable salt thereof. The present invention further provides processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of PDE9 associated diseases or disorders in mammals, including humans.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of 7-Isoquinolinecarboxaldehyde, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 87087-20-5, in my other articles.

Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem