Category: isoquinoline

Jin, Jing-Hai published the artcileAsymmetric Synthesis of Spirooxindole β-lactams via Isothiourea-catalyzed Mannich/lactamization Reaction of Aryl Acetic Acids with Isatin-derived Ketimines, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is homobenzotetramisole catalyzed Mannich lactamization cascade carboxylic acid isatin ketimine; spiro oxindole beta lactam asym synthesis.

An efficient [2+2] annulation strategy featuring homobenzotetramisole (HBTM)-catalyzed Mannich/lactamization cascade reaction of carboxylic acids with isatin-derived ketimines has been disclosed [e.g., phenylacetic acid + ketimine I â†?spirooxindole β-lactams II + III (96% overall, dr 88:12 resp., > 99% ee for II)]. This protocol affords a range of structurally diverse spirooxindole β-lactams bearing two vicinal stereogenic centers in good to high yields with good to excellent stereoselectivities.

Advanced Synthesis & Catalysis published new progress about [2+2] Cycloaddition reaction, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Takaishi, Kazuto published the artcileUnexpected Macrocyclic Multinuclear Zinc and Nickel Complexes that Function as Multitasking Catalysts for CO2 Fixations, Safety of 4-Methoxy-N-methylaniline, the main research area is epoxide carbon dioxide fixation binaphthyl bipyridyl zinc nickel catalyst; cyclic carbonate preparation; amine hydrosilane zinc nickel catalyst formylation methylation chemoselective DFT; tertiary amine preparation; N-functionalization; carbon dioxide fixation; cyclic carbonates; multinuclear complexes; self-assembly.

Unique self-assembled macrocyclic multinuclear ZnII and NiII complexes with binaphthyl-bipyridyl ligands (L) were synthesized. X-ray anal. revealed that these complexes consisted of an outer ring (Zn3L3 or Ni3L3) and an inner core (Zn2 or Ni). In the ZnII complex, the inner Zn2 part rotated rapidly inside the outer ring in solution on an NMR timescale. These complexes exhibited dual catalytic activities for CO2 fixations: synthesis of cyclic carbonates from epoxides and CO2 and temperature-switched N-formylation/N-methylation of amines with CO2 and hydrosilane.

Angewandte Chemie, International Edition published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Emayavaramban, Balakumar published the artcileCobalt-Catalyzed Reductive Alkylation of Amines with Carboxylic Acids, Computed Properties of 104-01-8, the main research area is cobalt catalyst reductive alkylation amine carboxylate; alkylation; amines; carboxylic acids; cobalt; reduction.

Direct reductive alkylation of amines with carboxylic acid was carried out by using an inexpensive, air-stable cobalt/triphos catalytic system with mol. hydrogen as the reductant. This efficient synthetic method proceeds through reduction and condensation, followed by reduction of the in situ-generated imine into the amine in a green catalytic process.

ChemSusChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Yong published the artcileMicrowave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is tetramic acid derivative preparation microwave irradiation; ethyl glyoxylate amine acid isonitrile tandem Ugi Dieckmann cyclization; Dieckmann cyclization; Ugi reaction; multicomponent reactions; nitrogen heterocycles; one-pot reaction.

A facile microwave-assisted method for the synthesis of tetramic acid derivatives I (R1 = Ph, Bn, 4-MeOC6H4, etc.; R2 = 3-F, 4-NO2, 3,4-(OMe)2, etc.; R3 = Ph, Bn, c-hexyl, 2,6-(Me)2C6H3) has been developed through an Ugi/Dieckmann cyclization strategy with DBU. This two-step one-pot procedure afforded the targeted tetramic acid analogs in good yields. With com. available Ugi starting materials, microwave irradiation, a simple operation, excellent yields, and a broad scope, this reaction has the potential to produce a large number of tetramic acid analogs, which cannot be easily accessed by the classic synthetic methods.

Beilstein Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mamidala, Ramesh published the artcilePalladacycle-Phosphine Catalyzed Methylation of Amines and Ketones Using Methanol, Product Details of C8H11NO, the main research area is amine ketone methylation palladacycle phosphine catalyst methanol.

Methylation of amines and ketones with palladacycle precatalyst was performed using methanol as an environmentally benign reagent. Various ketones and amines undergo methylation reaction to yield monomethylated amines or ketones in moderate to good isolated yields. Moreover, this protocol was tested for the chemoselective methylation of 4-aminobenzenesulfonamide. The scope of the reaction was further extended to the deuteromethylation of ketones.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Shihaozhi published the artcileCopper-Catalyzed Cascade N-Dealkylation/N-Methyl Oxidation of Aromatic Amines by Using TEMPO and Oxygen as Oxidants, Application of 4-Methoxy-N-methylaniline, the main research area is aryl formamide preparation; amine aryl cascade dealkylation oxidation catalyst copper.

A novel tandem N-dealkylation and N-Me aerobic oxidation of tertiary aromatic amines to N-arylformamides ArNC(O)H [Ar = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] using copper and TEMPO was developed. This methodol. suggested an alternative synthetic route from N-methylarylamines to N-arylformamides ArNC(O)H.

European Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Baranov, Vladimir V. published the artcileEfficient method for the synthesis of 1,3-unsubstituted 2-imino-5-oxooctahydroimidazo[4,5-d]imidazolium iodides based on thioglycolurils, Category: isoquinoline, the main research area is imino oxooctahydroimidazoimidazolium iodide preparation; isothiouronium salt preparation amine condensation; thioglycoluril methyl iodide methylation.

A facile and efficient two-step synthetic route to previously inaccessible 1,3-unsubstituted 2-imino-5-oxooctahydroimidazo[4,5-d]-imidazol-1-ium iodides, e.g., I (R = H, Me) has been developed using easily accessible thioglycolurils II (R1 = H, Me), MeI, and various primary amines, morpholine, or ethylene diamine. The structure of representative products and hydrogen-bonding pattern in their crystals have been investigated by X-ray diffraction.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Xuehao published the artcileThree-component reaction access to S-alkyl dithiocarbamates under visible-light irradiation conditions in water, Application In Synthesis of 5961-59-1, the main research area is triphenyl pyridinium tetrafluoroborate carbon disulfide amine deamination three component; alkyl dithiocarbamate preparation green chem.

An efficient and environmentally friendly visible-light promoted method for the synthesis of S-alkyl dithiocarbamates with a broad substrate scope and good functional group tolerance in water was developed. Most appealingly, the reaction was proceeded smoothly without any external photocatalyst was added. This method opens a new avenue towards S-alkyl dithiocarbamates, thus promising their broad applications in pharmaceutical chem. and sulfur chem.

Green Chemistry published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Leung, Gulice Yiu Chung published the artcileEfficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated On Demand, HPLC of Formula: 151-10-0, the main research area is sulfonamide preparation continuous flow; amine organometallic compound demetalation.

A simple and practical protocol was developed for the synthesis of sulfonamides RSO2R1 (R = Ph, 4-fluorophenyl, 2-benzofuranyl, etc; R1 = NH2, NHMe, morpholin-4-yl, benzyl, cyclopropyl, etc.) by reacting organometallic reagents RM (M = MgBr, Li) with SO2 gas generated on demand. SO2 was generated from readily available reagents safely in a highly contained and controlled fashion. The protocol allows the synthesis of sulfonamides without using either atom-inefficient SO2 surrogates or a SO2 cylinder that requires stringent storage regulations in the laboratory The protocol was successfully applied to the synthesis of sildenafil.

Organic Process Research & Development published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Schaub, Stefan published the artcileA Facile and Inexpensive Way to Synthesize N-trifluoromethyl Compounds, Application of 1,3-Dimethoxybenzene, the main research area is secondary amine trifluoromethylation; trifluoromethyl tertiary amine preparation.

A facile way to introduce CF3 groups on a large variety of secondary amines was developed by avoiding expensive and hazardous reagents. The advantage of the method could be demonstrated by obtaining crystalline tert-Bu 4-(trifluoromethyl)piperazine-1-carboxylate, a compound that previously was obtained as an oil. A major problem was the extreme sensitivity of these compounds toward moisture.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem