Category: isoquinoline

Ye, Ai-Hui published the artcileTMSCl-Catalyzed Electrophilic Thiocyano Oxyfunctionalization of Alkenes Using N-Thiocyano-dibenzenesulfonimide, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is chlorotrimethylsilane catalyzed electrophilic thiocyano oxyfunctionalization alkene; nitrogen thiocyano dibenzenesulfonimide electrophilic thiocyanation reagent.

Numerous electrophilic thiocyano oxyfunctionalization reactions of alkenes have been achieved using N-thiocyano-dibenzenesulfonimide, which is a new electrophilic thiocyanation reagent and could be easily prepared in two steps from dibenzenesulfonimide. This approach provides efficient, simple, and modular methods for the formation of SCN-containing heterocycles such as lactones, tetrahydrofurans, dihydrofurans, and dihydrobenzofurans in moderate to excellent yields. Meanwhile, diverse oxa-quaternary centers were rapidly constructed. Addnl., this protocol is free of transition metals and features broad substrate tolerance and mild reaction conditions.

Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Xin-Yu published the artcileSynthesis of Seleno Oxindoles via Electrochemical Cyclization of N-arylacrylamides with Diorganyl Diselenides, Name: 4-Methoxy-N-methylaniline, the main research area is selanylmethyl oxindole green preparation antitumor human; acrylamide diselenide electrochem tandem cyclization.

The tandem cyclization of acrylamides with diselenides facilitated by electrochem. oxidation was successfully developed. This strategy provided an environmentally friendly method for the construction of C-Se bond. A series of (arylselanylmethyl)oxindoles such as I [R1 = Me, Ph, 2-thienyl, etc.; R2 = H, 4-Me, 5-MeO, etc.; R3 = Me, Ph, Bn] with pharmacol. activity was obtained by using this well-designed tandem cyclization strategy. The in vitro antitumor activity of the compounds I [R1 = Ph; R2 = H; R3 = Me, Bn] was also screened through MTT assay. Results showed that the (arylselanylmethyl)oxindoles I [R1 = Ph; R2 = H; R3 = Me, Bn] exhibited better antitumor activity than other oxindole derivatives II [R = CF3, PhSO2].

Advanced Synthesis & Catalysis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kim, Yerin published the artcileEfficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel-Crafts Reactions of Donor-Acceptor Aziridines with N, N-Dialkylanilines, Category: isoquinoline, the main research area is diarylmethylamine scaffold preparation chemoselective; aziridine dialkylaniline Friedel Crafts Lewis acid catalyst.

A method for efficient and mild synthesis of diarylmethylamine scaffolds I [R1 = Ph, 1-naphthyl, 4-ClC6H4, etc.; R2 = Me, Et, Bn, etc.; R3 = 4-NMe2C6H4, 2-Me-4-NMe2C6H3, 1-pyrrolidyl, etc.] via Lewis acid catalyzed Friedel-Crafts reaction of donor-acceptor aziridines with N, N-dialkylanilines in high yields (up to 88%) was reported. This reaction was suitable for the synthesis of various compounds I and had a broad scope for electron-rich arenes, including dimethoxybenzene.

Synthesis published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bhatthula, Bharath Kumar Goud published the artcileA simple method for the synthesis of sulfonic esters, Application of 1,3-Dimethoxybenzene, the main research area is aryl heteroaryl sulfonic ester preparation solvent catalyst free; arene heteroarene dialkyl sulfate alkoxysulfonylation.

An efficient and simple approach for the direct synthesis of aryl and heteroaryl sulfonic esters was developed using DMS and DES as alkoxysulfonylation reagents. The reaction is operationally simple and scalable. This protocol does not require solvent, expensive catalysts, base, ligand additives or other reagents. A wide range of sulfonic esters were synthesized in moderate to good chem. yields. This method has the advantage of low cost, facile and tolerated a wide range of substrates.

Synthetic Communications published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gorman, Ryan M. published the artcileA copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is benzamidoethanylsulfonylbenzene preparation copper mediator radical cross dehydrogenative coupling elimination; alkylquinolinone preparation.

A new cyclization procedure for preparation 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides was described. Extensions to more complex substrates were also reported as are applications in target synthesis allowed access to natural products isolated from Oryza sativa and HOFQ.

Tetrahedron published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nguyen, Hai Truong published the artcileImidazolium Triflate Ionic Liquid Improves the Activity of ZnCl2 in the Synthesis of Pyrroles and Ketones, Product Details of C8H10O2, the main research area is pyrrole preparation; aniline acetonylacetone Paal Knorr reaction imidazolium triflate zinc catalyst; ketone preparation; arene acetic anhydride Friedel Crafts imidazolium triflate zinc catalyst.

An efficient catalytic system, ZnCl2/([AMIm]OTf), for the synthesis of pyrroles I (R = Ph, 2-methylphenyl, 4-nitrophenyl, 3,5-dichlorophenyl, etc.) and ketones R1C(O)CH3 (R1 = 1H-indol-3-yl, 5-chloro-1H-indol-3-yl, 5-bromo-1H-indol-3-yl, etc.) was developed. The method provides desired products in good to excellent yields with high selectivity under mild conditions.

Organic Preparations and Procedures International published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Huai-Bo published the artcileElectrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines, HPLC of Formula: 5961-59-1, the main research area is aryl amidine electrochem dehydrogenative cyclization; phenyl benzoimidazole preparation; C−H functionalization; amidine; electrochemical synthesis; oxidation; radical cyclization.

The development of efficient and sustainable methodologies for the synthesis of N-heterocycles was a constant focus of organic synthesis. An electrochem. method was reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chem. oxidants, or additives, and produced H2 as the only theor. byproduct.

ChemSusChem published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, He published the artcileIntermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis, Category: isoquinoline, the main research area is fused nitrogen heterocycle compound preparation chemoselective diastereoselective; azaarenium salt aniline paraformaldehyde dearomative annulation; ruthenium reductive catalysis.

Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions.

Nature Communications published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Suresh published the artcileMicrowave-Assisted Multicomponent Reaction: A Green and Catalyst-Free Method for the Synthesis of Poly-Functionalized 1,4-Dihydropyridines, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde aniline malononitrile dimethylacetylenedicarboxylate multicomponent reaction microwave irradiation; dimethyl phenyl phenyldihydropyridinedicarboxylate preparation green chem.

A facile and an efficient procedure for the synthesis of poly-substituted 1,4-dihydropyridine derivatives under catalyst-free conditions was established by a one-pot multi-component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach were: simple operation, non-toxic, short reaction time (< 5 min), excellent yields (93-98%), no column chromatog., clean reaction profile and environmentally friendly reaction. ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cao, An-Zhu published the artcileCopper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides via C(sp3)-Br/C(sp2)-H functionalization, HPLC of Formula: 5961-59-1, the main research area is oxindole preparation; aniline carbonyl alkyl bromide annulation copper catalyst.

A copper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides for the synthesis of 3,3′-disubstituted oxindoles is developed. Tandem C-H cycloamidation reactions of various α-carbonyl alkyl bromide derivatives including tertiary-α-bromoalkyl ketone esters, malonic esters and cycloalkanes, with N-aryl or alkyl substituted anilines, can be performed using this system, affording a vast array of valuable 3,3′-disubstituted oxindoles in moderate to good yields.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem