Category: isoquinoline

Ke, Lei published the artcileCatalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene, Formula: C11H12O3, the main research area is azoxyarene preparation anticancer catalyst oxidative coupling secondary alkylaniline.

Azoxyarenes are among important scaffolds in organic mols. Direct oxidative coupling of primary anilines provides a concise fashion to construct them. However, whether these scaffolds can be prepared from secondary N-alkylanilines is not well explored. Here, the authors present a catalytic selective oxidative coupling of secondary N-alkylaniline to afford azoxyarene with tungsten catalyst under mild conditions. In addition, azoxy can be viewed as a bioisostere of alkene and amide. Several “”azoxyarene analogs”” of the corresponding bioactive alkenes and amides showed comparable promising anticancer activities.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Evdokimov, Nikolai M. published the artcileOne-Step, Three-Component Synthesis of Pyridines and 1,4-Dihydropyridines with Manifold Medicinal Utility, Formula: C11H12O3, the main research area is aldehyde thiol malononitrile cyclization pyridine enamino nitrile preparation.

Privileged medicinal scaffolds based on the structures of 2-amino-3,5-dicyano-6-sulfanylpyridines and the corresponding 1,4-dihydropyridines have been prepared via a single-step, three-component reaction of structurally diverse aldehydes with various thiols and malononitrile. Mechanistic studies revealed that 1,4-dihydropyridines undergo oxidation by the intermediate Knoevenagel adducts rather than by air oxygen. Although the latter process undermines the yields of pyridines, it results in the formation of substituted enamino nitriles, promising antiinflammatory agents.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Qinfang published the artcileConstruct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is indenooxepine preparation; malononitrile aldehyde crotonate derived sulfur ylide annulation; cyclopropyl acrylate diastereoselective preparation; arylideneindenedione aldehyde crotonate derived sulfur ylide annulation.

For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione was reported using Na2CO3 as the base. This protocol was advantageous as it does not require prior preparation of arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione substrates, due to the independent participation of the base in the two reactions. This mild, operationally multicomponent process could be employed for the transformation of a wide variety of com. available aldehydes into the corresponding indeno[1,2-b]oxepines I [R = H, 4-CNC6H4, 2-OMeC6H4, etc.; R1 = Me, Et] or cyclopropyl acrylate core II in moderate to excellent yields under mild conditions.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fu, Lei-Han published the artcileAn ionic liquid-based green synthesis strategy: synthesis of dihydropyrimidinones by three-component Biginelli-type reaction of aliphatic aldehydes, aromatic aldehydes and urea, Quality Control of 598-50-5, the main research area is dihydropyrimidinone green preparation; aliphatic aldehyde aromatic urea three component ionic liquid catalyst.

An ionic liquid-based green synthesis of 3,4-dihydropyrimidin-2-(1H)-ones I [R1 = 4-NO2, 4-OMe, 4-Cl, etc.; R2 = nPr, iPr, n-Bu, etc.; R3 = Me, Et] via three-component Biginelli-type reaction of aliphatic aldehydes, aromatic aldehydes and urea was reported. The catalyst could be easily recycled and reused with similar efficacy for at least four cycles.

Heterocycles published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Quality Control of 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazanov, Daniil R. published the artcile2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation, Application In Synthesis of 86-51-1, the main research area is design synthesis biol evaluation trisalkoxyarylimidazoline p53 MDM2 interaction inhibitor; Anticancer; Fragmentary approach; Imidazolines; Nutlin analogues; Synthetic design.

Imidazoline-based small mol. inhibitors of p53-MDM2 interaction intended for the treatment of p53 wild-type tumors are the promising structures for design of anticancer drugs. Based on fragment approach we have investigated a key role of substituents in cis-imidazoline core for biol. activity of nutlin family compounds Although the necessity of the substituents in the Ph rings of cis-imidazoline has been shown, there are no studies in which the replacements of a halogen by other substituents have been investigated. A series of simple cis-imidazoline derivatives containing halogen, hydroxy and alkoxy-substituents were synthesized. The biol. activity of the compounds was studied using assays of cytotoxicity (MTT) and p53 level. It was found that the hydroxyl-derivatives were not cytotoxic whereas the alkoxy analogs were the same or more active as halogen-substituted compounds in cell viability test. The synthesized alkoxy derivatives induced an increase of p53 level and did not promote necrotic cell death in the concentration up to 40 μM.

Bioorganic & Medicinal Chemistry Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Xiaofeng published the artcileElectrochemical Tandem Olefination and Hydrogenation Reaction with Ammonia, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is ester nitrile preparation; aldehyde ketone electrochem Horner Wadsworth Emmons hydrogenation tandem reaction.

An electrochem. Horner-Wadsworth-Emmons/hydrogenation tandem reaction was achieved using ammonia as electron and proton donors. The reaction could give two-carbon-elongated ester and nitrile from aldehyde or ketones directly. This reaction could proceed with a catalytic amount of base or even without a base. The ammonia provides both the electron and proton for this tandem reaction and enables the catalyst-free hydrogenation of an α,β-unsaturated HWE intermediate. More than 40 examples were reported, and functional groups, including heterocycles and hydroxyl, were tolerated.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhu, Quan published the artcileSaegusa Oxidation of Enol Ethers at Extremely Low Pd-Catalyst Loadings under Ligand-free and Aqueous Conditions: Insight into the Pd(II)/Cu(II)-Catalyst System, Product Details of C11H12O3, the main research area is unsaturated aldehyde preparation; enol ether preparation Saegusa oxidation palladium catalyst.

A highly efficient and practical Pd(II)/Cu(OAc)2-catalyst system of Saegusa oxidation, which converts enol ethers to the corresponding enals with a number of diverse substrates at extremely low catalyst loadings (500 mol ppm) under ligand-free and aqueous conditions, is described. Its synthetic utility was demonstrated by large-scale applications of the catalyst system to important nature mols. This work allows Saegusa oxidation to become a highly practical approach to preparing enals and also suggests new insight into the Pd(II)/Cu(II)-catalyst system for dehydrogenation of carbonyl compounds and decreasing Pd-catalyst loadings.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pandey, Sushil K. published the artcileTerminal Olefins from Aldehydes through Enol Triflate Reduction, HPLC of Formula: 1205-17-0, the main research area is aldehyde enolization trifluoromethanesulfonation reduction; enol triflate reduction; terminal olefin preparation.

The transformation of aldehydes into terminal olefins through reduction of the corresponding enol triflates is described. The method is effective with both linear and α-branched aldehydes. Thus, PhCHMeCHO reacted with (F3CCO)2O in ClCH2CH2Cl containing 2,6-di-tert-butyl-4-methylpyridine at 70° for one hour to give a crude enol triflate which was directly treated with HCO2H in DMF containing Pd(OAc)2(PPh3)2 and Bu3N to give 65% PhC(Me):CH2.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, HPLC of Formula: 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ohashi, Masato published the artcileNickel-Catalyzed Formation of Fluorine-Containing Ketones via the Selective Cross-Trimerization Reaction of Tetrafluoroethylene, Ethylene, and Aldehydes, Computed Properties of 1205-17-0, the main research area is tetrafluoroethylene ethylene aldehyde nickel cross trimerization catalyst; tetrafluoropentanone derivative preparation.

In the presence of a catalytic amount of Ni(cod)2 and IPr (1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene), a cross-trimerization reaction of tetrafluoroethylene (TFE), ethylene, and aldehydes proceeded in a selective manner to afford a variety of 4,4,5,5-tetrafluoro-1-pentanone derivatives in good to excellent yields. The present system involves a five-membered nickelacycle key intermediate generated via the oxidative cyclization of TFE and ethylene.

Journal of the American Chemical Society published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Computed Properties of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhu, Longfei published the artcileSupported Iridium Catalyst for Clean Transfer Hydrogenation of Aldehydes and Ketones using Methanol as Hydrogen Source, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is zinc oxide support iridium nanocatalyst preparation; alc green preparation iridium nanocatalyst zinc oxide support; aldehyde ketone transfer hydrogenation iridium nanocatalyst methanol hydrogen donor.

The use of methanol as an abundant and low-toxic hydrogen source under mild and clean conditions is promising for the development of safe and sustainable reduction processes, but remains a daunting challenge. This work presents a recyclable ZnO-supported Ir catalyst for the additive-free transfer hydrogenation of aldehydes and ketones using methanol as the hydrogen source at 110°C, delivering alcs. in up to 98% yield. Mechanistic studies disclose that methanol was first dehydrogenated to formaldehyde and then fully decomposed into an active hydrogen species for hydrogenation. The superior performance is related to the high ratio of pos. charged IrOx species and their ultrafine dispersion over ZnO. And the delicate cooperation of IrOx and ZnO enhances the catalytic activities for the selective scission of O-H and less reactive C-H bonds in methanol, maintaining a good balance between methanol decomposition and C=O hydrogenation in this green transfer hydrogenation.

ChemCatChem published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem