Category: isoquinoline

Noruzian, Fatemeh published the artcileGuanidine hydrochloride catalyzed efficient one-pot pseudo five-component synthesis of 4,4′-(arylmethylene)bis(1H-pyrazol-5-ols) in water, Related Products of isoquinoline, the main research area is arylmethylene pyrazolols preparation green chem; hydrazine acetoacetate aldehyde Knoevenagel Michael reaction guanidine hydrochloride catalyst.

The present methodol. describes an efficient, environmentally friendly and simple protocol for the synthesis of some 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol) derivatives through a one-pot pseudo-five-component reaction of hydrazine hydrate/phenyl hydrazine, Et acetoacetate, and various aromatic aldehydes catalyzed by guanidine hydrochloride. This condensation reaction was performed by tandem Knoevenagel-Michael reaction in water under refluxing conditions giving the title compounds in 82-92% yields. Atom economy, simple operation, easy work-up, using inexpensive organocatalyst, high yields in short times, clean transformation, and environmentally benign are some of the important features of this new protocol.

Synthetic Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Surya Narayana published the artcileMnO2 on hydroxyapatite: A green heterogeneous catalyst and synthesis of pyran-carboxamide derivatives, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is aldehyde acetoacetanilide malononitrile manganese oxide hydroxyapatite catalyst multicomponent water; pyran carboxamide green preparation.

Three different loadings of MnO2 on hydroxyapatite (MnO2/Hap) were synthesized and the hydroxyapatite supported MnO2 materials were characterized by several anal. techniques including FT-IR, P-XRD, TEM and SEM anal. 3% MnO2/HAp material proved highly efficient catalyst for the synthesis of a series of ten pyran-carboxamide derivatives (yield 91-98%) in aqueous medium at room temperature (RT) conditions, via one-pot multi-component reaction, of which nine were new moieties. The prominent features of the protocol are excellent yields, high atom efficiency, short reaction times (15 min), recyclable catalyst and no need for column separation

Inorganic Chemistry Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Jing published the artcileMicrowave-assisted multicomponent reaction: An efficient synthesis of indolyl substituted and spiroxindole pyrido[2,3-d]pyrimidine derivatives, SDS of cas: 86-51-1, the main research area is indolyl spiroxindole pyridopyrimidine preparation microwave irradiation; diaminopyrimidinone aryl aldehyde isatin cyanoacetyl indole three component reaction; tandem Knoevenagel condensation Michael addition.

An efficient and catalyst-free protocol for the synthesis of a series of indole substituted I (R = H, Me; R1 = H, 7-Me; Ar = Ph, 4-FC6H4, 2-thienyl, etc.) or spiroxindole-consisted dihydropyrido[2,3-d]pyrimidine derivatives II (R = H, Me; R1 = H, 7-Me; R2 = H, 5-Me, 5-F, 5-Br) by one-pot three-component reaction of 2,6-diaminopyrimidin-4-one, various aryl aldehydes or isatins, and 3-cyanoacetyl indoles under microwave irradiation was investigated. The advantages of this methodol. include high yields of products, short reaction time, easy work-up procedure and broad substrate scope.

Synthetic Communications published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, SDS of cas: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Khosravi, Zeynab published the artcileFe3O4@SiO2@sulfated boric acid as superparamagnetic and recyclable nanocatalyst-assisted, one-pot, pseudo four-component synthesis of 5-amino-2-aryl-3H-chromeno[4,3,2-de][1,6]naphthyridine-4-carbonitrile derivatives, Related Products of isoquinoline, the main research area is magnetite silica boric acid sulfated chromeno naphthyridine recyclability stability.

The catalytic performance of the superparamagnetic nanocatalyst Fe3O4@SiO2@Sulfated boric acid as a green, recyclable, and acidic solid catalyst in the synthesis of chromeno[4,3,2-de][1,6]naphthyridine derivatives has been studied. Chromeno[4,3,2-de][1,6]naphthyridine derivatives via a pseudo four-component reaction from aromatic aldehydes (1 mmol), malononitrile (2 mmol), and 2′-hydroxyacetophenone in the presence of Fe3O4@SiO2@Sulfated boric acid (0.004 g) as a nanocatalyst in 3 mL of water as a green solvent at 80°C has been synthesized. The advantages of this method are higher product yields in shorter reaction times, easy recyclability and reusability of the catalyst, and easy work-up procedures. The nanocatalyst was reused at least six times. The nanocatalyst retained its stability in the reaction, and after reusability, it was separated easily from the reaction by an external magnet.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bryant, Dillon J. published the artcileSynthesis and Study of a Dialkylbiaryl Phosphine Ligand; Lessons for Rational Ligand Design, SDS of cas: 151-10-0, the main research area is methylphosphinedimethoxybiphenyl ligand preparation catalyst palladium cross coupling aryl chloride; crystal structure methylphosphinedimethoxybiphenyl ligand palladium complex; mol structure methylphosphinedimethoxybiphenyl ligand palladium complex.

The rational design and synthesis of a novel dialkylbiarylphosphine ligand, 2′-(dimethylphosphine)-2,6-dimethoxy-1,1′-biphenyl (MeSPhos), for Pd-catalyzed C-N cross-coupling reactions is described. Based on previous results, it was hypothesized that a ligand with electronic properties similar to (2-biphenyl)dimethylphosphine (MeJPhos) but with greater steric bulk would allow the cross-coupling of previously inaccessible deactivated aryl chlorides. As predicted, MeSPhos exhibited similar electronic properties to MeJPhos. However, MeSPhos surprisingly showed a significantly smaller steric profile than MeJPhos. In comparison to the widely used CySPhos (2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl), MeSPhos promoted the oxidative addition of highly deactivated aryl chlorides for which CySPhos was ineffective, but significantly decreased the rate of reductive elimination. The kinetics of cross-coupling reactions showed that the altered steric and electronic parameters of MeSPhos had a significant impact on the rate of cross-coupling, and the decreased steric bulk had a profound deleterious impact on the catalyst stability. With regard to this latter point, only the most activated aryl chlorides reacted at a sufficient rate to overcome the rate of catalyst decomposition The relation between the electron-donating ability of the phosphine ligand and the rate of oxidative addition is complex, and they also illustrate that increasing substitution on the biphenyl structure does not necessarily increase the steric bulk of the ligand.

Organometallics published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jing, Ke published the artcileVisible-light photoredox-catalyzed carboxylation of benzyl halides with CO2: Mild and transition-metal-free, COA of Formula: C9H10O3, the main research area is aryl acetic acid preparation visible light; benzyl chloride bromide carbon dioxide carboxylation photoredox catalyst.

The visible-light photoredox-catalyzed carboxylation of benzyl chlorides and bromides with CO2 has been reported. With inexpensive organic dyes as photocatalysts and amines as electron donors, this carboxylation proceeds well in the absence of sensitive organometallic reagents, transition metal catalysts, or metallic reductants. A wide range of com. available and inexpensive benzyl halides undergo such carboxylation to give valuable aryl acetic acids, including several pharmaceutical mols. and drug precursors, in moderate to high yields. Moreover, this reaction features mild reaction conditions (one atm. pressure of CO2 and room temperature), broad substrate scope, good functional group tolerance, easy scalability, and low catalyst loading, thus providing an efficient approach for the assembly of aryl acetic acids.

Chinese Journal of Catalysis published new progress about Benzyl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kasama, Kengo published the artcileEnantiodivergent Synthesis of Axially Chiral Biphenyls from σ-Symmetric 1,1′-Biphenyl-2,6-diol Derivatives by Single Lipase-Catalyzed Acylative and Hydrolytic Desymmetrization, Quality Control of 151-10-0, the main research area is axially chiral biphenyl enantiodivergent preparation biphenyldiol lipase catalyst desymmetrization.

The enzymic acylative desymmetrization of σ-sym. 2′-halo-1,1′-biphenyl-2,6-diols was achieved for the first time using com. available Burkholderia cepacia lipase immobilized on diatomaceous earth to give (S)-mono esters. The hydrolytic desymmetrization of the corresponding diacetates was also achieved using the same lipase to give (R)-mono esters. The authors’ results, therefore, demonstrate that a single lipase can conduct the enantiodivergent synthesis of axially chiral biphenyl compounds in high chem. and optical yields.

European Journal of Organic Chemistry published new progress about Biphenyls Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bazyar, Zahra published the artcileOn/Off O2 Switchable Photocatalytic Oxidative and Protodecarboxylation of Carboxylic Acids, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is photocatalytic oxidative protodecarboxylation carboxylic acid.

Photoredox catalysis in recent years has manifested a powerful branch of science in organic synthesis. Although merging photoredox and metal catalysts has been a widely used method, switchable heterogeneous photoredox catalysis has rarely been considered. Herein, we open a new window to use a switchable heterogeneous photoredox catalyst which could be turned on/off by changing a simple stimulus (O2) for two opponent reactions, namely, oxidative and protodecarboxylation. Using this strategy, we demonstrate that Au@ZnO core-shell nanoparticles could be used as a switchable photocatalyst which has good catalytic activity to absorb visible light due to the localized surface plasmon resonance effect of gold, can decarboxylate a wide range of aromatic and aliphatic carboxylic acids, have multiple reusability, and are a reasonable candidate for synthesizing both aldehydes/ketones and alkane/arenes in a large-scale set up. Some biol. active mols. are also shown via examples of the direct oxidative and protodecarboxylation which widely provided pharmaceutical agents.

Journal of Organic Chemistry published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vilches-Herrera, Marcelo published the artcileInfluence of the bite natural angle of bidentate diphosphine ligands in the syngas-free branched hydroformylation of β-functionalized olefins, Application In Synthesis of 1205-17-0, the main research area is bidentate diphosphine ligand branched hydroformylation beta olefin.

The correlation between the activity, regio- and chemoselectivity of Rh-diphosphine catalyst and the ligand bite natural angle (βn) in the syngas-free hydroformylation of allyl cyanide was studied. A screening of Xantphos type and diphosphine alkyl ligands with different bite natural angles was studied. Interesting, a switch in the linear to the branch regioselectivity was found. Wide βn favor a linear regioselectivity whereas smaller βn gave the branched aldehyde as the major product. Modification of the substituents at the phosphorus atoms of the diphosphine ligands produced a dramatic change in the hydroformylation. Others β-functionalized olefins were also branched hydroformylated.

Catalysis Communications published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Baricelli, Pablo J. published the artcileHydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem