Category: isoquinoline

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6624-49-3, The compound 3-isoquinolinecarboxylic acid (0801-132) (1.0 g, 5.78 mmol, 1.0 eq.)Dissolved in 30 ml of methanol,Sulfuric acid (0.5 ml) was then added and the reaction was refluxed overnight.After the reaction is finished, add sodium bicarbonate solutionpH to 8, extracted with dichloromethane, liquid-separated, and the organic phase dried over anhydrous sodium sulfate.Spin-drying afforded the compound 3-isoquinolinecarboxylic acid methyl ester (810 mg, 75percent).

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
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66491-03-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66491-03-0,7-Amino-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

Intermediate 16 (400mg) was dissolved with 10ml of acetone, was added trimethylsilyl cyanide (2ml) and acetic acid 2ml, sealed tube, heated to 60 deg.] C overnight.The reaction was cooled to room temperature, concentrated under reduced pressure after adding water, an aqueous solution (100ml ¡Á 3) and extracted with ethyl acetate, the ethyl acetate layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to dryness to give a yellow oil It was flash column chromatography (petroleum ether: ethyl acetate = 2: 1) to give the intermediate 17 (460mg).

The synthetic route of 66491-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences,; Duan, WenHu; Wan, huixin; Xia, GuangXin; Mei, deCheng; Lin, Yipeng; Liu, Xuejun; Shen, JingKang; (53 pag.)CN103804358; (2016); B;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80278-67-7,Isoquinoline-5-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a dried two-neck round-bottom flask containing DMF (0.7mL for 1.10mmol of starting material) chilled in an ice bath, POCl3 (1.95 equiv) was added slowly. After stirring for 20min, a solution of an indole derivative (1.0 equiv) in DMF (3mL for 1.10mmol of starting material) was added dropwise. The reaction was allowed to warm to room temperature and allowed to stir for 1.5h. The reaction was quenched by adding ice followed by 1N NaOH (40mL) dropwise in an ice bath. The crude mixture was allowed to stand at room temperature and the precipitate formed was filtered to afford the 3-formyl-indole derivative product., 80278-67-7

The synthetic route of 80278-67-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W.; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 344 – 367;,
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34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0187] 6-bromoisoquinoline (1.80g, 8.66 mmol) was dissolved in DCM (40 mL), after cooling down the reaction to 0C m-CPBA (2.30 g, 1.3 eq, 77% max) was added slowly in small portion. The reaction was warmed up to RT to become a kind of white suspension. In 4 hours, 1 OOmL DCM was added into the solution, and washed with saturated Na2C03 solution, water and brine. The separated organic layer was dried over Na2S04 and removed under the vacuum to get the yellow solid N-oxide 6-bromoisoquinoline without further purification (1.82 g, yield -93%).

34784-05-9, As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.

Reference£º
Patent; AN, Songzhu; CUREGENIX, INC.; WO2014/159733; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.

52986-70-6, General procedure: A flame-dried and nitrogen flushed 50 mL Schlenk flask, equipped with a magnetic stirringbar, was charged with the appropriate isoquinoline 7a-c (prepared according to lit. [1,2])(2.00 mmol) in dry THF (10 mL). TMPMgClLiCl (1.0 M in THF/toluene; 3.00 mL, 3.00 mmol)was added to this solution dropwise over 2 min. The reaction mixture was stirred at roomtemperature for 4 h. After cooling to 0 C, a solution of iodine (0.761 g, 3.00 mmol) in dryTHF (3 mL) was added dropwise to the reaction mixture. The cooling bath was removed andthe mixture was stirred at room temperature for 1 h. Then the mixture was quenched withsatd. aqueous NH4Cl solution (4 mL) and satd. aqueous Na2S2O3 solution (4 mL). Afterextraction with dichloromethane (3 ¡Á 20 mL), the combined organic layers were dried withNa2SO4, and concentrated under reduced pressure. The residue was purified by flashcolumn chromatography (ethyl acetate/dichloromethane = 1:5).

52986-70-6 6-Methoxyisoquinoline 11040978, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Melzer, Benedikt C.; Bracher, Franz; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1564 – 1571;,
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119-65-3, Isoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

lntermediate-12: 3-Bromoisoquinoline: To a stirred solution of isoquinoline (24 g, 186 mmol) in AcOH (50 mL) was added NBS (36.2 g, 204.6 mmol) at RT and the reaction mixture was heated to 100 2C overnight. Then it was cooled to RT and concentrated under reduced pressure. The crude product obtained was purified by flash column chromatography (5% EtOAc:Hexanes) to furnish the title compound (9.2 g, 23.8%) as an oil., 119-65-3

As the paragraph descriping shows that 119-65-3 is playing an increasingly important role.

Reference£º
Patent; LUPIN LIMITED; KULKARNI, Sanjeev, Anant; MADAN, Sachin; JANA, Nirmal, Kumar; TALE, Prashant, Vitthalrao; CHEEMALA, Narasimha, Murthy; MAHANGARE, Sachin, Jaysing; VIDHATE, Prashant, Popatrao; KULKARNI, Chaitanya, Prabhakar; PATEL, Sapana, Suresh; PATIL, Amolsing, Dattu; ZADE, Seema, Prabhakar; SHINDE, Rohan, Mahadev; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2013/5168; (2013); A2;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

90.0 mg of (1S)-N’,N’-dimethyl-1-phenyl-ethane-1,2-diamine (550 mumol) was dissolved in 10.0 mL of DMF, to which 153 mg of HBTU (600 mumol), 105 mg of 6-isoquinolinecarboxylic acid (600 mumol) and 284 g of N, N-diisopropyl ethylamine (2.19 mmol) were added. The reaction mixture was stirred for 1 h and extracted with ethyl acetate and water. Then the aqueous phase was extracted twice with ethyl acetate, and the organic phases were combined, dried with anhydrous sodium sulfate, desolventized under vacuum and purified by column chromatography to give 52 mg of benzyl-N-((2S)-2-(isoquinoline-6-formamide)-2-phenyl-ethyl) carbamate (0.13 mmol) with a yield of 24%., 106778-43-2

The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hitgen Ltd.; LI, Jin; ZHANG, Dengyou; FENG, Jingchao; LIAO, Wei; LIN, Li; LI, Si; CHEN, Wei; (41 pag.)EP3640242; (2020); A1;,
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56469-02-4, 3,4-Dihydro-5-hydroxy-1(2H)-isoquinolinone is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,56469-02-4

Intermediate Q5-Methoxy-3,4-dihydro-2H-isoquinolin-1 -oneTo a stirring solution of 5-hydroxy-3,4-dihydroisoquinolin-1(2H)-one (200 mg, 1.226 mmol) in DMF (8 ml) was added Cs2C03 (599 mg, 1.839 mmol). The reation mixture was left to stir for 20 minutes at 50 C and then treated with methyl iodide (0.115 ml, 1.839 mmol). After stirring at 50 C for 30 min, the mixture was diluted with EtOAc water. The organic portion was separated and washed with water, brine, dried (MgS04) and concentrated in vacuo to afford the title compound as a pale yellow solid; LC-MS Rt =1.08 mins; MS m/z 178.1 [M+H]+; Method 2minLC_v002.

The synthetic route of 56469-02-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ATKINSON Benjamin; BEATTIE David; CULSHAW Andrew James; DEVEREUX Nicholas James; MCKENNA Jeffrey; DALE James; WO2011/92293; A1; (2011);,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.26947-41-1,3-Isoquinolinecarbonitrile,as a common compound, the synthetic route is as follows.,26947-41-1

3-Cyanoisoquinoline (1.047 g, 6.79 mmol) was suspended in 6 M HCl (aq) (50 mL) and refluxed at 95¡ã C. for 18 h. The reaction was cooled to RT, and the volatiles removed under vacuum to provide the carboxylic acid (2.07 g) that was used as is.

The synthetic route of 26947-41-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; Scott, Jack D.; Stamford, Andrew W.; Gilbert, Eric J.; Cumming, Jared N.; Iserloh, Ulrich; Misiaszek, Jeffrey A.; Li, Guoqing; US2015/307465; (2015); A1;,
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26947-41-1, 3-Isoquinolinecarbonitrile is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,26947-41-1

General procedure: Cells were streaked onto LBamp plate from frozen stocks of E. coli JM109 (PVL 1343 +MS13) containing NDO2 and incubated at 37¡ãC for 12h. Single colonies were selected for preculture preparation. A sterilized culture flask containing 10mL of LBamp+kan medium was inoculated with a single colony of E. coli JM109 (PVL 1343 +MS13) and the preculture was grown on an orbital shaker at 37¡ãC for 12hat 180rpm. 200mL of MSB medium containing 300mgL?1 thiamine, 4mLL?1 ampicillin, 2mLL?1 kanamycin (kan) and 20mL 20percent glucose, was transferred into 1L sterile shake flask and was inoculated with 2mL of preculture and resulting culture was grown at 30¡ãC until the culture turbidity reached 1.5 to 2.0at 660nm. Cells were induced with salicylic acid (as dioxane solution, 2mML?1 of MSB) and were grown for 2.5h under same conditions. Culture was centrifuged at 4500rpm (3736g) for 15minat 4¡ãC and supernatant was separated from cells. The supernatant was decanted and cells were resuspended in fresh MSB medium containing 300mgL?1 thiamine, 4mLL?1 ampicillin, 2mLL?1 kanamycin and 20mL 20percent glucose. An aliquot amount of substrate was added either directly or as a solution in 1,4-dioxane. Conversion of substrate was monitored with HPLC and the biotransformation was stopped when HPLC showed no further decrease in substrate peak or increase in product peak (18?24h). (0028) After completion of biotransformation, the biomass was removed by centrifugation. The supernatant was concentrated at 30¡ãC to 5?10mL under reduced pressure. The concentrate was stirred with acid-free EtOAc for 30?60min. Acid free EtOAc was prepared by stirring with saturated solution of Na2CO3 at low temperature. Organic layer was separated and the concentrate was again extracted with EtOAc. The combined organic layers were dried over Na2SO4 and the solvent was evaporated at reduced pressure at 40¡ãC. The crude material was analyzed by 1H NMR. Purification was performed using an automated MPLC with fraction collector.

The synthetic route of 26947-41-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zia, Muhammad Farooq; Vasko, Agnes G.; Riedl, Zsuzsanna; Hametner, Christian; Hajos, Gyoergy; Mereiter, Kurt; Mihovilovic, Marko D.; Tetrahedron; vol. 72; 46; (2016); p. 7348 – 7355;,
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