Heterocyclic Building Blocks-Isoquinoline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.215453-26-2,6-Bromoisoquinolin-1-ylamine,as a common compound, the synthetic route is as follows.

Into a 250-mL round-bottom flask, was added 6-bromoisoquinolin-1-amine (500 mg, 2.24 mmol), NCS (359 mg, 2.69 mmol) and chloroform (50 mL). The reaction mixture was stirred for 24 h at 60 C. in an oil bath. The solution was diluted with 50 mL of water and extracted with 2*50 mL of dichloromethane. The organic layers were combined, dried over sodium sulfate and concentrated under vacuum. The residue was purified by silica gel column chromatography with methanol:dichloromethane (3:10). This resulted in 400 mg (69%) of 6-bromo-4-chloroisoquinolin-1-amine as a purple solid. [M+H]+ 356/358. Rt 1.12 min (method R).

The synthetic route of 215453-26-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Merck Patent GmbH; Cancer Research Technology, Ltd.; SCHIEMANN, Kai; BLAGG, Julian; MALLINGER, Aurelie; RINK, Christian; SEJBERG, Jimmy; HONEY, Mark; (139 pag.)US2016/16951; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

90806-58-9, 5-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of Cap-138, step a (2.34 g, 14.7 mmol) in anhydrous dichloromethane (50 mL) at room temperature was added meto-chloroperbenzoic acid (77%, 3.42 g, 19.8 mmol) in one portion. After being stirred for 20 h, powdered potassium carbonate (2.0 g) was added and the mixture was stirred for 1 h at room temperature before it was filtered and concentrated to afford Cap-138, step b as a pale, yellow solid which was sufficiently pure to carry forward (2.15 g, 83.3%). 1H NMR (CDC13, 400 MHz) delta 8.73 (d, J= 1.5 Hz, 1H), 8.11 (dd, J = 7.3, 1.7 Hz, 1H), 8.04 (d,J=7.1 Hz, 1H), 7.52 (t, J= 8.1 Hz, 1H), 7.28 (d, J = 8.3 Hz, 1H), 6.91 (d, J= 7.8 Hz, 1H), 4.00 (s, 3H); Rt= 0.92 min, (Cond.-Dl); 90% homogenity index; LCMS: Anal. Calc. for [M+H]+ C10H10N02: 176.07; found: 176.0.

As the paragraph descriping shows that 90806-58-9 is playing an increasingly important role.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; PACK, Shawn, K.; TYMONKO, Steven; PATEL, Bharat, P.; NATALIE, JR., Kenneth, J.; BELEMA, Makonen; WO2011/59850; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem