Category: 90806-58-9

Dong, Jianyang; Wang, Xiaochen; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Photoredox-Catalyzed Redox-Neutral Minisci C-H Formylation of N-Heteroarenes>, Recommanded Product: 5-Methoxyisoquinoline, the main research area is heteroarene dioxoisoindolinyl diethoxyacetate iridium photocatalyst regioselective Minisci formylation; formyl heteroarene preparation.

A protocol for redox-neutral Minisci C-H formylation of N-heteroarenes using 1,3-dioxoisoindolin-2-yl 2,2-diethoxyacetate as a formyl equivalent at room temp was reported. This scalable benchtop protocol offered a distinct advantage over traditional reductive carbonylation and Minisci C-H formylation methods in not requiring the use of carbon monoxide, pressurized gas, a stoichiometric reductant, or a stoichiometric oxidant.

Advanced Synthesis & Catalysis published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Recommanded Product: 5-Methoxyisoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Shihui; Pan, Peng; Fan, Huaqiang; Li, Hao; Wang, Wei; Zhang, Yongqiang published the artcile< Photocatalytic C-H silylation of heteroarenes by using trialkylhydrosilanes>, Safety of 5-Methoxyisoquinoline, the main research area is photocatalytic silylation heteroarene hydrosilane green chem.

The efficient and selective C-H silylation of heteroarenes, especially the pharmaceutically relevant electron-deficient heteroarenes, represents a great challenge in organic synthesis. Herein we wish to report a distinctive visible light-promoted photocatalytic C-H silylation approach that enables the direct coupling of trialkylhydrosilanes with both electron-deficient and -rich heteroarenes as well as with cyano-substituted arenes in moderate to high yields and with good regioselectivity. The protocol features operational simplicity, mild reaction conditions, and the use of safe and readily available Na2S2O8, bis(trimethylsilyl) peroxide (BTMSPO) or iPr3SiSH as the radical initiators. Notably, the challenging bulky and inert trialkylhydrosilanes, such as (t-butyldimethyl)silane (tBuMe2SiH) and (triisopropyl)silane (iPr3SiH), work smoothly with the protocol. Moreover, despite the higher stability of tBuMe2Si silylation products, our studies revealed their great reactivity and versatility in diverse C-Si-based chem. transformations, providing an operationally simple, low-cost, and environmentally benign synthetic technol. for mol. construction and elaboration.

Chemical Science published new progress about Green chemistry. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Safety of 5-Methoxyisoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published the artcile< Quantum dots enable direct alkylation and arylation of allylic C(sp3)-H bonds with hydrogen evolution by solar energy>, Category: isoquinoline, the main research area is alkene amine preparation quantum dot photocatalyst cross coupling alkylation; heteroarene alkene quantum dot photocatalyst arylation; cadmium sulfide quantam dot preparation; quantum dot cadmium selenide preparation.

A general and mild strategy using semiconductor quantum dots (QDs) as photocatalysts for coupling a broad range of available allylic C(sp3)-H bonds with α-amino C-H bonds or heteroarenes, resp., under sunlight irradiation (> 85 examples) was reported. The protocol bypasses stoichiometric oxidant or reductant and pre-functionalization of both the coupling partners and produces hydrogen (H2) as the byproduct. The outstanding efficiency and selectivity and step- and atom-economy represents the first direct alkylation and arylation of allylic C(sp3)-H bonds with hydrogen evolution powered by solar energy.

Chem published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pan, Yang; Li, Jiangtao; Li, Zhefeng; Huang, Feng; Ma, Xiaofeng; Jiao, Wei; Shao, Huawu published the artcile< An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes>, Product Details of C10H9NO, the main research area is trifluoromethyl heteroarene preparation regioselective; heteroarene trimethyltrifluoromethylsilane trifluoromethylation; perfluoroalkyl heteroarene preparation regioselective; trimethyltrifluoroalkylsilane heteroarene perfluoroalkylation.

An effective and regioselective strategy for trifluoromethylation and perfluoroalkylation of isoquinolines I (R1 = OMe, Ph, Br, etc.; R2 = H, formyl, OMe, NO2; R3 = Me, 2-phenylethynyl, Cl, etc.; R4 = H, OMe; R5 = H, Ph, Br) and heteroarenes R6H (R6 = phenanthridin-6-yl, thieno[2,3-c]pyridin-7-yl, quinazolin-2-yl, etc.) was developed. By combination of TMSCnF2n+1 (n = 1, 2, 3) with PIFA, the method achieved the corresponding perfluoroalkylated products R6CnF2n+1 (n = 1, 2, 3) with broad functional group tolerance.

Chemical Communications (Cambridge, United Kingdom) published new progress about Density functional theory, B3LYP. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Product Details of C10H9NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hu, Yijie; Ye, Liufeiyang; Chen, Jie; Zhang, Hui; Deng, Hongmei; Lin, Jin-Hong; Cao, Weiguo published the artcile< An Efficient Construction of CF3-Substituted Spirooxindole-Fused Benzo[a]quinolizidines by a Three-Component Cyclization>, Recommanded Product: 5-Methoxyisoquinoline, the main research area is isoquinoline perfluoroalkylpropiolate oxoindolinylidene propanedinitrile three component cyclization; perfluoroalkyl dicyano spirooxindoline benzoquinolizidine carboxylate preparation.

A convenient three-component cyclization was described for the efficient construction of CF3-substituted spirooxindole-fused benzo[a]quinolizidines by using CF3-propiolate as a building block. This attractive protocol may find great synthetic utility since CF3-containing complex structures were installed by a one-step cyclization under mild conditions.

European Journal of Organic Chemistry published new progress about Alkynes, fluoro Role: RCT (Reactant), RACT (Reactant or Reagent). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Recommanded Product: 5-Methoxyisoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dong, Jianyang; Yue, Fuyang; Liu, Jianhua; Song, Hongjian; Liu, Yuxiu; Wang, Qingmin published the artcile< Visible-light-mediated three-component Minisci reaction for heteroarylethyl alcohols synthesis>, Application In Synthesis of 90806-58-9, the main research area is heteroarylethyl alc green diastereoselective preparation; heteroaryl alkene three component Minisci visible light iridium catalyst.

Herein, a mild, modular, practical Minisci reaction for catalytic synthesis of heteroarylethyl alcs. such as ArCH(R1)CHR2OH [Ar = quinol-2-yl, isoquinolin-1-yl, 2-benzothiazolyl, etc.; R1R2 = CH2(CH2)2CH2, CH2CH2CH2; R1 = On-Bu, Me; R2 = H, Me] via sequential addition of H2O and N-heteroarenes across olefinic double bonds was reported. This scalable protocol was used for direct hydroxy-heteroarylation of olefins with a wide range of N-heteroarenes and could be expected to permit rapid conversion of abundant feedstock materials into medically relevant mols.

Green Chemistry published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation) (heteroarylethyl). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Application In Synthesis of 90806-58-9.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Tao; Liang, Kangjiang; Zhang, Yang; Hu, Dongyan; Ma, Zhixian; Xia, Chengfeng published the artcile< Three-Component Minisci Reaction with 1,3-Dicarbonyl Compounds Induced by Visible Light>, Name: 5-Methoxyisoquinoline, the main research area is quinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle; isoquinoline preparation visible light Minisci dicarbonyl vinyl ether heterocycle.

A three-component Minisci reaction coupling of 1,3-dicarbonyl compounds with vinyl ethers and quinolines or isoquinolines under visible light is developed. The 1,3-dicarbonyl compound undergoes single-electron oxidation to afford an electrophilic 1,3-dicarbonyl radical under visible light irradiation Due to the polarity of the free radical, the electrophilic radical adds to the electron-rich olefin to afford the nucleophilic radical. It coupled with the heteroarene to afford the three-component coupling products.

Organic Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Name: 5-Methoxyisoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Su, Yong-Liang; Liu, Geng-Xin; De Angelis, Luca; He, Ru; Al-Sayyed, Ammar; Schanze, Kirk S.; Hu, Wen-Hao; Qiu, Huang; Doyle, Michael P. published the artcile< Radical Cascade Multicomponent Minisci Reactions with Diazo Compounds>, Quality Control of 90806-58-9, the main research area is heteroarene preparation regioselective photochem; aromatic heterocycle alkene diazo compound tandem multicomponent Minisci iridium.

Based on the strategy of polarity reversal in the generation of free radicals derived from diazo compounds, R1C(=N2)R2[R1 = ethoxycarbonyl, (benzyloxy)carbonyl, N,N-diethylcarbamoyl, etc.; R2 = H, C(O)OMe] photocatalyzed multicomponent reactions (MCRs) of nitrogen aromatic heterocycles, e.g., 4-methylquinoline, alkenes R3CH=CH2 [R3 = methoxymethyl, cyclohexyl, 4-[(furan-2-yl)carbonyloxy]butyl, etc.], and diazo compounds form functionalized derivatives e.g., Et 4-(4-methylquinolin-2-yl)-6-phenylhexanoate in good to high yields and exacting regioselectivities. The carbon radicals generated from the acceptor diazo compounds are electrophilic, and their selective additions with alkenes provide nucleophilic radicals, which enable the further rapid assembly with various heteroarenes. A delicate balance has been achieved between the activation of heteroarenes through protonation and the decomposition of diazo compounds by the same acid. This multicomponent Minisci reaction shows high functional group tolerance, especially in the incorporation of biol. active mols. Detailed mechanistic studies that include photophys. measurements elaborate this radical cascade reaction. Furthermore, this transformation provides new opportunities for versatile reactions of diazo compounds in radical cascade multicomponent coupling reactions.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Quality Control of 90806-58-9.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Zhen-Hong; Wei, Yuan-Yuan; Li, Na; Sun, Yong-Chang; Yang, Shao-Yan; Wang, Kuan; Wang, Weitao; Ma, Xiaoxue; Liu, Zhao-Tie published the artcile< N-formylation of isoquinoline derivatives with CO2 and H2 over a heterogeneous Ru/ZIF-8 catalyst>, Recommanded Product: 5-Methoxyisoquinoline, the main research area is isoquinoline derivative formylation heterogeneous calayst property.

Chem. utilization of CO2 is one of the fundamental strategies to synthesize value-added chems. and reduce the CO2 emission. N-formyl-1,2,3,4-tetrahydroisoquinoline derivatives (FTHIQs) are important chems. for the synthesis of medical intermediates and alkaloids. N-formylation of isoquinoline derivatives (IQs) with CO2 is an ideal protocol to synthesize the FTHIQs and utilize the CO2 source. In the present work, we prepared a heterogeneous Ru/ZIF-8 catalyst with a Ru loading of 2 wt% by a simple impregnation method and assessed its performances in the N-formylation of IQs and CO2 with H2. The Ru/ZIF-8 catalyst offered high IQ conversion of 98% and FTHIQ selectivity of 93% in the reaction under relatively mild conditions (150°C, 2 MPa CO2, and 6 MPa H2). The catalyst possessed good universality and reusability, showing a potential in wide application of N-formylation of highly unsaturated nitrogen-containing isoquinolines.

Journal of Experimental Nanoscience published new progress about Catalyst supports. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Recommanded Product: 5-Methoxyisoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhou, Wei; Liu, Hao; Guo, Yongyi; Gu, Yiting; Han, Jing; Chen, Jie; Deng, Hongmei; Shao, Min; Zhang, Hui; Cao, Weiguo published the artcile< Base-promoted [3+2] cycloaddition/aromatization cascade reaction under air: An approach to access perfluoroalkylated pyrrolo[2,1-a]isoquinolines>, Synthetic Route of 90806-58-9, the main research area is isoquinoline bromomethyl aryl ketone perfluoroalkynoate dipolar cycloaddition aromatization cascade; pyrroloisoquinoline perfluoroalkylated preparation.

A facile [3 + 2] cycloaddition / aromatization cascade reaction with broad substrate scopes in up to 94% isolated yield was disclosed herein. This tandem approach was accomplished by employing isoquinolines and bromoacetyl derivatives with Me perfluoroalk-2-ynoates as readily available starting materials. In the presence of base, this method provides an efficient access to synthesize perfluoroalkylated pyrrolo[2,1-a]isoquinolines with ambient air as a terminal oxidant at room temperature in one-pot.

Journal of Fluorine Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Synthetic Route of 90806-58-9.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem