Zhou, Wei; Liu, Hao; Guo, Yongyi; Gu, Yiting; Han, Jing; Chen, Jie; Deng, Hongmei; Shao, Min; Zhang, Hui; Cao, Weiguo published the artcile< Base-promoted [3+2] cycloaddition/aromatization cascade reaction under air: An approach to access perfluoroalkylated pyrrolo[2,1-a]isoquinolines>, Synthetic Route of 90806-58-9, the main research area is isoquinoline bromomethyl aryl ketone perfluoroalkynoate dipolar cycloaddition aromatization cascade; pyrroloisoquinoline perfluoroalkylated preparation.
A facile [3 + 2] cycloaddition / aromatization cascade reaction with broad substrate scopes in up to 94% isolated yield was disclosed herein. This tandem approach was accomplished by employing isoquinolines and bromoacetyl derivatives with Me perfluoroalk-2-ynoates as readily available starting materials. In the presence of base, this method provides an efficient access to synthesize perfluoroalkylated pyrrolo[2,1-a]isoquinolines with ambient air as a terminal oxidant at room temperature in one-pot.
Journal of Fluorine Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 90806-58-9 belongs to class isoquinoline, and the molecular formula is C10H9NO, Synthetic Route of 90806-58-9.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem