Tag: 1125-80-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1125-80-0,3-Methylisoquinoline,as a common compound, the synthetic route is as follows.

Preparation 1-9 3-Methyl-1,2,3,4-Tetrahydroisoquinoline 3.0 g of 3-methylisoquinoline(21 mM) and 50 ml of methanol were mixed and 0.84 g of platinum oxide was added thereto. The mixture was subjected to hydrogenation at 40 psi and filtered. The filtrate was concentrated under a reduced pressure, to give 3.3 g of the title compound.

As the paragraph descriping shows that 1125-80-0 is playing an increasingly important role.

Reference£º
Patent; Yuhan Corporation; US5686458; (1997); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1125-80-0,3-Methylisoquinoline,as a common compound, the synthetic route is as follows.

The mixture of 3-methylisoquinoline (782 mg, 5.46mmol), N-bromosuccinimide (1.069 g, 6.01 mmol) and azobisisobutyronitrile (134 mg, 0.819mmol) in CCl4 (100 mL) were refluxed for 1 h. Ten percent of Na2S2O3 (20 mL) was then addedto quench the reaction. The mixture was diluted with DCM (20 mL). The organic layer wasseparated and washed with brine, dried over Na2SO4 and concentrated. To the residue was added12DCM, the precipitate was filtered off and the filtrate was purified with silica gel (EA/PE = 1/20)to give 387 mg white solid, in 32% yield. 1H NMR (400 MHz, CDCl3) 9.25 (s, 1H), 7.98 (d, J= 8.04 Hz, 1H), 7.82 (d, J = 8.06 Hz, 1H), 7.77 (s, 1H), 7.71 (m, 1H), 7.62 (m, 1H), 4.75 (s, 2H);13C NMR (100 MHz, CDCl3) delta 152.92, 150.10, 136.26, 130.84, 127.94, 127.83, 127.65, 126.67,119.77, 34.63. IR (Diamond, cm-1) numax 3058.1, 1627.5, 1218.2, 956.0, 893.9, 753.4, 733.1. mp 90.5 – 92 C.

1125-80-0 3-Methylisoquinoline 14306, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Yuan, Yunyun; Elbegdorj, Orgil; Beletskaya, Irina O.; Selley, Dana E.; Zhang, Yan; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5045 – 5048;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem