Tag: 200-300

On February 2, 2006, Fernandes, Prabhavathi B.; Mailman, Richard Bernard; Nichols, David Earl published a patent.Recommanded Product: 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of hexahydrobenzophenanthridines as dopamine receptor agonists for treatment of pulmonary edema. And the patent contained the following:

The title hexahydrobenzophenanthridines, hexahydrothienophenanthridines, phenylbenzodiazepines, chromenoisoquinolines, and naphthoisoquinolines with general formula of I and II [wherein X = H, OH, alkoxy, etc.; Y = O or (un)substituted CH2; R = H or alkyl; R1 = H, alkyl, acyl, etc.; R2-R4 = independently H, alkyl, Ph, halo, etc; R5-R7 = independently H, alkyl, or alkenyl; R8-R10 = independently H, OH, alkyl, Ph, halo, or alkoxy; R11 = H, alkyl, acyl, etc.; R12 = H, OH, alkoxy, etc.], or pharmaceutically acceptable salts thereof were prepared as dopamine receptor agonists for the treatment of pulmonary edema. For example, III was prepared in a multi-step synthesis. III showed agonistic activity with EC50 of 28±9 and 10±2 nM against human D1-like and D5 receptors, resp. Formulations as aerosols and dry powders, and methods for treating a patient having pulmonary edema are described. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Recommanded Product: 4-Bromo-5-nitroisoquinoline

The Article related to dopamine receptor agonist treatment pulmonary edema formulation human, preparation benzophenanthridine thienophenanthridine phenylbenzodiazepine chromenoisoquinoline naphthoisoquinoline and other aspects.Recommanded Product: 4-Bromo-5-nitroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On September 25, 1975, Serban, Alexander published a patent.HPLC of Formula: 58142-46-4 The title of the patent was Isoquinolines. And the patent contained the following:

Substituted isoquinolines (I, where R1, R3, R4, R5, R6, R7 and R8 = H, alkyl, halo, nitro, amino, mono- and dialkyl substituted amino, mono- and diaryl substituted amino, acyl substituted amino, cyano, arylthio, alkylthio, and salts of these compounds) were prepared and are effective in controlling or eradicating undesired vegetation, insects, acarina, or fungi. Thus, 4-bromo-5-nitroisoquinoline (I) [58142-46-4], prepared by nitration of 4-bromoisoquinoline [1532-97-4], showed fungicidal activity. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).HPLC of Formula: 58142-46-4

The Article related to fungicide isoquinoline derivative, herbicide isoquinoline derivative, acaricide isoquinoline derivative, insecticide isoquinoline derivative, isoquinoline derivative pesticide and other aspects.HPLC of Formula: 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On June 1, 2006, Yamada, Rintaro; Seto, Minoru published a patent.Application In Synthesis of 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of diazaphenalene derivatives as myosin-control light chains phosphorylation inhibitors. And the patent contained the following:

Title compounds I [R1, R5-R8 = H, halo, hydroxy, etc.; X1···X2 = -CH(R2)CH(R3)-, -CH(R2)CH(R3)CH(R4)-, -C(R2):C(R3)-, etc.; R2-R4 = H, alkyl; A1, A11, A2, A21 = H, alkyl; Y = -CH(A3)-, -CH(A3)C(A4)(A41)-, single bond, etc.; A3, A4, A41 = H, alkyl; Z = hydroxy, -NR(A6)(A61); A6 = H, alkyl; A61 = H, alkyl, alkyl substituted with aryl group, etc.; further details on A1-A4 and A6 are given.] and salts thereof were prepared For example, reductive amination of tert-Bu 3-oxo-1-piperidinecarboxylate with 5-amino-4-vinylisoquinoline, e.g., prepared from 5-amino-4-bromoisoquinoline, followed by reaction with potassium tert-butoxide and treatment with HCl afforded compound II hydrochloride. In myosin-control light chains phosphorylation inhibition assays, compound II hydrochloride exhibited the IC50 value of ≤10 μM. Compounds I are claimed useful for the treatment of glaucoma, bronchial asthma, etc. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Application In Synthesis of 4-Bromo-5-nitroisoquinoline

The Article related to diazaphenalene preparation myosin control light chain phosphorylation inhibitor, glaucoma bronchial asthma treatment diazaphenalene preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 4-Bromo-5-nitroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On December 28, 2000, Nichols, David E.; Grubbs, Russell A.; Mailman, Richard B. published a patent.Electric Literature of 58142-46-4 The title of the patent was Preparation of chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands. And the patent contained the following:

The title compounds I [R1, R2, R3 = H, alkyl, alkenyl; R8 = H, alkyl, phenoxy protecting group; X9 = H, halo, OR where R = H, alkyl, phenoxy protecting group, etc.; R4, R5, R6 = H, alkyl, Ph, halo, OR], potent dopamine receptor ligands, were prepared E.g., N-propyl-8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2-de]isoquinoline was prepared The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Electric Literature of 58142-46-4

The Article related to chromenoisoquinoline preparation dopamine receptor ligand, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 25, 2015, Wu, Lingyun; Yao, Yuanshan; Chen, Zhaoguo; Chen, Shuhui published a patent.Quality Control of 4-Bromo-5-nitroisoquinoline The title of the patent was Preparation of isoquinolinesulfonyl derivatives as Rho kinase inhibitors. And the patent contained the following:

The invention relates to isoquinolinesulfonyl derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use as Rho kinase inhibitors. For instance, the invention compound I was prepared and gave a ROCK kinase inhibition IC50 value of <0.1μM. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Quality Control of 4-Bromo-5-nitroisoquinoline

The Article related to isoquinolinesulfonyl preparation rho kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 4-Bromo-5-nitroisoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 5, 2015, Wu, Lingyun; Yao, Yuanshan; Chen, Zhaoguo; Chen, Shuhui published a patent.SDS of cas: 58142-46-4 The title of the patent was Preparation of isoquinolinesulfonyl derivatives as Rho kinase inhibitors. And the patent contained the following:

The invention relates to isoquinolinesulfonyl derivatives (e.g., I) and their pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical preparations comprising them, and their use as Rho kinase inhibitors. For instance, the invention compound I was prepared and gave a ROCK kinase inhibition IC50 value of <0.1μM. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).SDS of cas: 58142-46-4

The Article related to isoquinolinesulfonyl preparation rho kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On November 30, 1989, Volovenko, Yu. M.; Litvinenko, S. V.; Babichev, F. S. published an article.Computed Properties of 58142-46-4 The title of the article was Annulation of benzoindolizine rings to quinoxaline nucleus. And the article contained the following:

Quinoxalineacetonitriles I (R3 = Me, Ph, or 4-MeC6H4) react with isoquinolines II (R1 = H, R2 = H, NO2; R1 = Br, R2 = NO2) 2-4 h in DMF at 160° or reflux to give quant. benzindolizinoquinoxalines III. The experimental process involved the reaction of 4-Bromo-5-nitroisoquinoline(cas: 58142-46-4).Computed Properties of 58142-46-4

The Article related to benzindolizinoquinoxalinecarbonitrile, indolizinoquinoxaline benz, quinoxaline benzindolizino, isoquinoline quinoxalineacetonitrile reaction, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Computed Properties of 58142-46-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Tao; Hu, Mengshi; Chen, Yong; Xiang, Mingli; Tang, Minghai; Qi, Wenyan; Shi, Mingsong; He, Jun; Yuan, Xue; Zhang, Chufeng; Liu, Kongjun; Li, Jiewen; Yang, Zhuang; Chen, Lijuan published their research in Journal of Medicinal Chemistry on December 10 ,2020. The article was titled 《N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms》.Related Products of 186390-79-4 The article contains the following contents:

In this study, we described a series of N-(pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine derivatives as selective JAK2 (Janus kinase 2) inhibitors. Systematic exploration of the structure-activity relationship though cyclization modification based on previously reported compound 18e led to the discovery of the superior derivative 13ac. Compound 13ac showed excellent potency on JAK2 kinase, SET-2, and Ba/F3V617F cells (high expression of JAK2V617F mutation) with IC50 values of 3, 11.7, and 41 nM, resp. Further mechanistic studies demonstrated that compound 13ac could downregulate the phosphorylation of downstream proteins of JAK2 kinase in cells. Compound 13ac also showed good selectivity in kinase scanning and potent in vivo antitumor efficacy with 82.3% tumor growth inhibition in the SET-2 xenograft model. Moreover, 13ac significantly ameliorated the disease symptoms in a Ba/F3-JAK2V617F allograft model, with 77.1% normalization of spleen weight, which was more potent than Ruxolitinib. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(cas: 186390-79-4Related Products of 186390-79-4)

tert-Butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(cas: 186390-79-4) belongs to isoquinoline.Related Products of 186390-79-4 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

《Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors》 was written by Chen, Ping; Norris, Derek; Haslow, Kristin D.; Murali Dhar, T. G.; Pitts, William J.; Watterson, Scott H.; Cheney, Daniel L.; Bassolino, Donna A.; Fleener, Catherine A.; Rouleau, Katherine A.; Hollenbaugh, Diane L.; Townsend, Robert M.; Barrish, Joel C.; Iwanowicz, Edwin J.. Computed Properties of C9H7BrN2 And the article was included in Bioorganic & Medicinal Chemistry Letters on April 7 ,2003. The article conveys some information:

Screening of our inhouse compound collection led to the discovery of 5-bromo-6-aminoisoquinoline (I) as a weak inhibitor of IMPDH. Subsequent optimization of I afforded a series of novel 2-isoquinolinoaminooxazole-based inhibitors, e.g., II, with single-digit nanomolar potency against the enzyme. In the experiment, the researchers used many compounds, for example, 5-Bromoisoquinolin-6-amine(cas: 566943-98-4Computed Properties of C9H7BrN2)

5-Bromoisoquinolin-6-amine(cas: 566943-98-4) belongs to isoquinoline.Computed Properties of C9H7BrN2 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Buchman, Marek; Farney, Elliot P.; Greszler, Stephen N.; Altenbach, Robert J.; Gfesser, Gregory A.; Voight, Eric A. published an article on January 7 ,2022. The article was titled 《Lithioarene Cycliacylation and Pd-Catalyzed Aminoethylation/Cyclization to Access Electronically Diverse Saturated Isoquinoline Derivatives》, and you may find the article in Journal of Organic Chemistry.Application of 186390-79-4 The information in the text is summarized as follows:

Authors report operationally facile methods for the synthesis of substituted dihydroisoquinolinones and tetrahydroisoquinolines from readily accessible o-bromobenzyl bromides and o-bromobenzaldehydes, resp. While classical electrophilic aromatic substitution reactions are tailored to the construction of saturated isoquinolines derived from electron-rich precursors, authors demonstrate efficient syntheses from electronically diverse substrates to produce cyclized products as single regioisomers. After reading the article, we found that the author used tert-Butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(cas: 186390-79-4Application of 186390-79-4)

tert-Butyl 6-nitro-3,4-dihydroisoquinoline-2(1H)-carboxylate(cas: 186390-79-4) belongs to isoquinoline.Application of 186390-79-4 Isoquinoline is a structural isomer of quinoline, and quinoline derivatives are fused ring compounds of pyridine and benzene rings, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem