With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22960-16-3,Isoquinoline-4-carbaldehyde,as a common compound, the synthetic route is as follows.
22960-16-3, Step A 4-Hydroxymethylisoquinoline 4-Isoquinolinecarboxaldehyde (6.15 g, 39.13 mmoles) (prepared by the method of: J. B. Wommack. T. G. Barbee, Jr., D. J. Thoennes, M. A. McDonald and D. E. Pearson, J. Heterocyclic Chem., 1969, 6, 243-245.) was dissolved in anhydrous dichloromethane (369 mL) and the solution was cooled to 0 C. Borane-dimethyl sulfide complex (1 M in THF) (5.23 mL, 5.09 mmoles) (as described in: E. Mincione, J. Org. Chem., 1978, 43, 1829-1830) was added and the mixture was stirred at 0 C. for a 1.5 h. Additional borane-dimethylsulfide complex (1 M in THF) (10.455 mL, 1.35 mmoles) was added and the reaction was stirred for an additional 2 h at 0 C. Methanol (93.3 mL) was added and the solution was evaporated to dryness and chromatographed on silica gel using 2-3% (10% conc. NH4OH in methanol)-dichloromethane as the eluant to give unreacted 4-Isoquinolinecarboxaldehyde (~23%), 4(1.2-dihydroisoquinoline)carboxaldehyde (identical to that described in Preparative Example 63.
The synthetic route of 22960-16-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Schering Corporation; US6362188; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem