With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39989-39-4,7-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.
TMPMgCl¡¤LiCl (1.0 M in THF/toluene; 5.65 mL, 5.65 mmol) was added dropwise at roomtemperature to a solution of 7-methoxyisoquinoline (600 mg, 3.77 mmol) in dry THF (11 mL).After 4 h the reaction mixture was cooled to 0C, a solution of iodine (1.43 g, 5.65 mmol) indry THF (6.65 mL) was added dropwise and the resulting mixture stirred while warming to room temperature over 1 h. Sat. aq. NH4Cl (6 mL) and sat. aq. Na2S2O3 (6 mL) were addedand the organic materials extracted using DCM (3 x 50 mL). The combined organic layerswere dried over Na2SO4 and concentrated in vacuo. The resulting crude product was purifiedby flash column chromatography (EtOAc/hexanes 1:9) to give 1-iodo-7-methoxyisoquinoline(S1) (469 mg, 1.64 mmol, 44%) as a yellowish solid.
The synthetic route of 39989-39-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Kraus, Yvonne; Glas, Carina; Melzer, Benedikt; Gao, Li; Heise, Constanze; Preusse, Monique; Ahlfeld, Julia; Bracher, Franz; Thorn-Seshold, Oliver; European Journal of Medicinal Chemistry; vol. 186; (2020);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem