With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62882-02-4,6-Chloroisoquinoline,as a common compound, the synthetic route is as follows.
General procedure: 1,2,3,4-Tetrahydro-isoquinoline(1g, 7.5 mmol) was dissolved in 5 mL of anhydrous acetonitrile. Then to thissolution was slowly added 2-chloro- or 2-bromo-benzyl compound (7.5 mmol) and the reaction was carried out overnight at room temperature. The solvent wasremoved under reduced pressure. The residue was resuspended in 1 ml of DMSO andpurified using C18 flash chromatography as described above.
As the paragraph descriping shows that 62882-02-4 is playing an increasingly important role.
Reference£º
Article; Farha, Maya A.; Koteva, Kalinka; Gale, Robert T.; Sewell, Edward W.; Wright, Gerard D.; Brown, Eric D.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 3; (2014); p. 905 – 910;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem