6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,6624-49-3
General procedure: Removal of the Boc protecting group of compound 5 was preformed at room temperature for 1 h with a solution of HCl 4N in dioxane. The mixture was then concentrated in vacuo, diluted with MeOH, and concentrated several times in vacuo. The residue was coupled with various carboxylic acids (1.1 equiv), in the presence of BOP (1.1 equiv) and DIEA (pH=9) for 2 h, in DCM. The mixture was then concentrated in vacuo, and the residue was dissolved in AcOEt. The organic layer was successively washed with aqueous solutions of 1M KHSO4, saturated NaHCO3, and brine. The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo to yield the desired compound. All the final compounds were purified by preparative HPLC on a C18 column using a water/acetonitrile/TFA 0.1percent gradient.
The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Blayo, Anne-Laure; Maingot, Mathieu; Aicher, Babette; M’Kadmi, Cline; Schmidt, Peter; Mueller, Gilbert; Teifel, Michael; Guenther, Eckhard; Gagne, Didier; Denoyelle, Sverine; Martinez, Jean; Fehrentz, Jean-Alain; Bioorganic and Medicinal Chemistry Letters; vol. 25; 1; (2015); p. 20 – 24;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem