Tag: 82827-09-6

82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

82827-09-6, Example 25 6-Bromo-4-chloroisoquinolin-1(2H)-one 6-Bromoisoquinolone (300 mg) was dissolved in N,N-dimethylacetamide (7.0 mL), NCS (215 mg) was added to the solution and the mixture was stirred at 50 C. for 50 minutes. Water was added to the reaction liquid, the insoluble material precipitated out of the liquid was collected by filtration and then washed with isopropyl alcohol to give a desired product (245 mg) as yellow powder. 1H NMR (CDCl3, 400 MHz): delta 7.56 (1H, d, J=6.1 Hz), 7.78 (1H, dd, J=8.6, 1.8 Hz), 7.92 (1H, d, J=1.8 Hz), 8.14 (1H, d, J=8.6 Hz), 11.72 (1H, s). ESIMS (+): 258 [M+H]+.

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kohno, Yasushi; Sumiya, Tatsunobu; Takita, Satoshi; Kojima, Akihiko; US2011/178041; (2011); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Under nitrogen atmosphere, 22 mg of 60% sodium hydride was added at 0C to 3 ml solution of dimethylformamide with 100 mg of 6-bromo-2H-isoquinoline-1-one, and the mixture was stirred for 30 min. 0.04 ml of ethyl iodide was added at 0C, and the mixture was stirred at room temperature for 3 hours. Cold water was added to the reaction solution, extracted with chloroform. Chloroform layer was washed with saturated saline solution, and dried with anhydrous sodium sulfate. After distilling out the solvents under reduced pressure, the residues were separated and purified by thin-layer chromatography (hexane/ethyl acetate=3/1) to obtain 30 mg of the above compound as a white solid. 1HNMR(400MHz,CDCl3.)delta.:1.38(3H,t,J=7.4Hz), 4.04(2H,q,J=7.2Hz), 6.41(1H,d,J=7.2Hz), 7.10(1H,d,J=7.6Hz), 7.56(1H,dd,J=1.8,8.6Hz), 7.67(1H,d,J=2.0Hz), 8.28(1H,d,J=8.4Hz) ESI-MS Found:m/z 253.9[M+H]+

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1726585; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem