Tag: M.W=150-200

Zhuang, Xiuzheng published the artcileSelective catalysis for the reductive amination of furfural toward furfurylamine by graphene-co-shelled cobalt nanoparticles, Name: 2,3-Dimethoxybenzaldehyde, the main research area is graphene cobalt catalyst furfural reductive amination furfurylamine.

Amines with functional groups are widely used in the manufacture of pharmaceuticals, agricultural chems., and polymers but most of them are still prepared through petrochem. routes. The sustainable production of amines from renewable resources, such as biomass, is thus necessary. For this reason, we developed an eco-friendly, simplified, and highly effective procedure for the preparation of a non-toxic heterogeneous catalyst based on earth-abundant metals, whose catalytic activity on the reductive amination of furfural or other derivatives (more than 24 examples) proved to be broadly available. More surprisingly, the cobalt-supported catalyst was found to be magnetically recoverable and reusable up to eight times with an excellent catalytic activity; on the other hand, the gram-scale tests catalyzed by the same catalyst exhibited the similar yield of the target products in comparison to its smaller scale, which was comparable to the com. noble-based catalysts. Further results from a series of anal. technologies involving XRD, XPS, TEM/mapping, and in situ FTIR revealed that the structural features of the catalyst are closely in relation to its catalytic mechanisms. In simple terms, the outer graphitic shell is activated by the electronic interaction as well as the induced charge redistribution, enabling the easy substitution of the -NH2 moiety toward functionalized and structurally diverse mols., even under very mild industrially viable and scalable conditions. Overall, this newly developed catalyst introduces the synthesis of amines from biomass-derived platforms with satisfactory selectivity and carbon balance, providing cost-effective and sustainable access to the wide applications of reductive amination.

Green Chemistry published new progress about Adsorption. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Jiacheng published the artcileMinisci-Type Alkylation of N-Heteroarenes by N-(Acyloxy)phthalimide Esters Mediated by a Hantzsch Ester and Blue LED Light, Application In Synthesis of 104-01-8, the main research area is alkylated quinoline preparation; quinoline acyloxy phthalimide ester Minisci type alkylation HE mediated; isoquinoline alkylated preparation; acyloxy phthalimide ester isoquinoline Minisci type alkylation HE mediated; pyridine alkylated preparation; phthalimide ester acyloxy pyridine Minisci type alkylation HE mediated.

A synthetic method that enabled the Hantzsch ester (HE)-mediated Minisci-type C2-alkylation of quinolines, isoquinolines and pyridines by N-(acyloxy)phthalimide esters (NHPI) to afford alkylated N-heterocyclic products, e.g., I, under blue LED (light emitting diode) light (456 nm) was described. Achieved under mild reaction conditions at room temperature, the metal-free synthetic protocol was shown to be applicable to primary, secondary and tertiary NHPIs to give the alkylated N-heterocyclic products in yields of 21-99%. On introducing a chiral phosphoric acid, an asym. version of the reaction was also realized and provided product enantiomeric excess (ee) values of 53-99%.

Advanced Synthesis & Catalysis published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Navale, Balu S. published the artcilePropargyl α-aryl-α-diazoacetates as robust reagents for the effective C-H bond functionalization of 1,3-diketones via scandium catalysis, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is propargyl aryl dicarbonyl compound preparation; diketone propargyl aryl diazoacetate alkylation scandium catalyst.

Propargyl α-aryl-α-diazoacetates RC(=N2)C(O)OCH2CCH [R = 4-ClC6H4, naphthalen-2-yl, 3,4-(H3CO)2C6H3, etc.] a new class of reagents is developed for the effective C-H bond functionalization of 1,3-diketones R1C(O)CH2C(O)R1 (R1 = Me, Et, Ph, 4-H3CC6H4, 4-H3COC6H4) at room temperature The combination of scandium triflate and propargyl α-aryl-α-diazoacetates proved to be efficient catalyst-reagent system for the controlled C-H bond functionalization to afford 1,3-dicarbonyl alkylation products RCH(CH(C(O)R1)2)C(O)OCH2CCH. The protocol uses inexpensive Sc(OTf)3 (5 mol%) and the reaction did not require the use of expensive catalysts or ligands and worked efficiently at room temperature The practicality of the protocol has been demonstrated by the gram scale synthesis.

Tetrahedron Letters published new progress about Alkylation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Clausen, Per Axel published the artcileBiocidal spray product exposure: Measured gas, particle, and surface concentrations compared with spray model simulations, Synthetic Route of 1205-17-0, the main research area is biocidal spray product simulation air pollution healt risk; Aerosols; ConsExpo Web; disinfectant; modeling.

The purpose of the study was to compare measured air and surface concentrations after application of biocidal spray products with concentrations simulated with the ConsExpo Web spray simulation tool. Three different biocidal spray products were applied in a 20 m3 climate test chamber with well-controlled environmental conditions (22 ± 1°C, 50 ± 2% relative humidity, and air exchange rate of 0.5 h-1). The products included an insect spray in a pressurized spray can, another insect spray product, and a disinfectant, the latter two applied sep. with the same pumped spray device. The measurements included released particles, airborne organic compounds in both gas and particle phase, and surface concentrations of organic compounds on the wall and floor in front of the spraying position and on the most remote wall. Spraying time was a few seconds and the air concentrations were measured by sampling on adsorbent tubes at 9-13 times points during 4 h after spraying. The full chamber experiment was repeated 2-3 times for each product. Due to sedimentation the concentrations of the particles in air decayed faster than explained by the air exchange rate. In spite of that, the non-volatile benzalkonium chlorides in the disinfectant could be measured in the air more than 30 min after spraying. ConsExpo Web simulated concentrations that were about half of the measured concentrations of the active substances when as many as possible of the default simulation parameters were replaced by the exptl. values. ConsExpo Web was unable to simulate the observed faster decay of the airborne concentrations of the active substances, which might be due to underestimation of the gravitational particle deposition rates. There was a relatively good agreement between measured surface concentrations on the floor and calculated values based on the dislodgeable amount given in the selected ConsExpo Web scenarios. It is suggested to always supplement simulation tool results with practical measurements when assessing the exposure to a spray product.

Journal of Occupational and Environmental Hygiene published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Synthetic Route of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Yanqin published the artcileEffects of N-, P-, or O-containing ligands on gold-based complex catalysts for acetylene hydrochlorination, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is acetylene hydrochlorination nitrogen phosphorus oxygen ligand gold complex catalyst.

In line with the fulfillment of international Minamata Convention and the urgent need for developing non-mercury catalysts, Au-Lx/AC catalysts were synthesized and evaluated for the hydrochlorination of acetylene. The results showed that the interaction between ligands and Au species contributed to the enhanced catalytic activity with important and different roles of each ligand. Depending on the high electronegativity of heteroatoms, all the prepared catalysts had effectively improved their adsorption and activation capacity of hydrogen chloride. Specifically, the N-containing ligands in catalysts increased the dispersion of Au species and an enhanced adsorption of acetylene was observed While, the coordination of P-containing ligands with Au can increase the relative content of active Aun+ species and the O-containing ligands rather decreased the adsorption of acetylene. Furthermore, all the prepared Au-Lx/AC catalysts showed good stabilities based on the inhibition of the agglomeration of Au components or of coking deposition.

Applied Catalysis, A: General published new progress about Adsorption. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vidic, Jasmina published the artcileGold Surface Functionalization and Patterning for Specific Immobilization of Olfactory Receptors Carried by Nanosomes, Product Details of C11H12O3, the main research area is gold surface functionalization patterning immobilization olfactory receptor carried nanosome.

There is substantial interest in engineering solid supports to achieve functional immobilization of membrane receptors both for investigation of their biol. function and for the development of novel biosensors. Three simple and practical strategies for immobilization of a human olfactory receptor carried by nanosomes are presented. The basis of the functionalization of solid gold surfaces is a self-assembled monolayer (SAM) containing biotinyl groups. Biotinyl groups are subsequently used to attach neutravidin and then biotinylated monoclonal antibody directed against the receptor to allow its specific grafting. Surface plasmon resonance technique is implemented for real-time monitoring of step-by-step surface functionalization and, in addition, for testing the functional response of immobilized olfactory receptors. The authors show that OR1740 is functional when immobilized via a tag attached to its C-terminus, but not via its N-terminus. Finally, the authors demonstrate that gold surfaces can be patterned by the SAMs tested using microcontact printing. AFM images of immobilized nanosomes onto a patterned surface suggest that small nanosomes flatten and fuse into larger vesicles but do not merge into a continuous layer. The whole study emphasizes the outstanding performances of the BAT/PEGAT SAM, which could be useful for developing on-a-chip sensor formats for membrane receptor investigations and use.

Analytical Chemistry (Washington, DC, United States) published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chiang, Chao-Lung published the artcileEnhancement of CO2 adsorption and separation for non-porous Zn/Co azolate frameworks via ethanol-induced structural transformation, Application In Synthesis of 104-01-8, the main research area is carbon dioxide zinc cobalt azolate adsorption separation.

Non-porous zinc/cobalt azolate frameworks with diamond-type crystal structure (MAF-31/ZIF-D-CoM) have been synthesized in large scale with an acid-catalyzed process. Afterward, an ethanol exposure process was applied for 1, 7, and 14 days to transform MAF-31/ZIF-D-CoM into porous T-MAF-4/T-ZIF-67. Two porous zinc/cobalt azolate frameworks standards (MAF-4/ZIF-67) with sodalite-type crystal structures were prepared with a solvent-free method for comparison with T-MAF-4/T-ZIF-67. Effects of ethanol vapor exposure on structual transformation of MAF-31/ZIF-D-CoM were characterized throughly. Obvious structural transfomations between non-porous and porous zinc/cobalt azolate frameworks were found with X-ray diffraction (XRD), Field-emission scanning electron microscope (FE-SEM), and X-ray absorption near-edge structure/extended X-ray absorption fine structure (XANES/EXAFS) spectra. After the 14-day ethanol vapor exposure, the CO2 adsorption uptakes of MAF-31 and ZIF-D-CoM in low/high pressures were enhanced from 5.18 × 10-5/0.68 and 1.20 × 10-4/0.18 to 1.76 × 10-3/8.27 and 1.99 × 10-3/11.2 mmol/g, resp. The CO2 selectivities of MAF-31/ZIF-D-CoM were also improved from 0.29/2.34 to 6.33/16.47. In addition, CO2 adsorption over zinc/cobalt azolate frameworks obeyed both Langmuir/Freundlich adsorption isotherm models with good agreements.

Journal of the Taiwan Institute of Chemical Engineers published new progress about Adsorption. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Csendes, Zita published the artcileInfluence of the Ionic Liquid on the Activity of a Supported Ionic Liquid Phase FeII Pincer Catalyst for the Hydrogenation of Aldehydes, Related Products of isoquinoline, the main research area is silica supported ionic liquid iron pincer catalysis aldehyde hydrogenation; Hydrogenation; Ionic liquids; Iron; Supported catalysts; Sustainable chemistry.

The catalytic hydrogenation of different aldehydes to the corresponding alcs. was investigated using an FeII hydride pincer complex as catalyst in the supported ionic liquid phase (SILP) reaction mode. Two different ionic liquids of the type [X4441][NTf2] with X=N or P were applied with mesoporous silica gel as support, which was coated first with a chemisorbed monolayer of the corresponding modified IL to remove acidic surface OH-groups and to prevent IL leaching. Quant. conversion with turn-over frequencies in the order of 1000 h-1 were obtained for various aromatic and heteroaromatic aldehydes and highly selective aldehyde reduction was observed also for substrates containing reducible C=C bonds. Aldehydes with longer aliphatic chains or cycloalkyl substituents, however, showed no conversion here, in contrast to a previous study with an imidazolium-based ionic liquid These differences were ascribed primarily to differences in substrate/ionic liquid interactions. Whereas [N4441][NTf2] and [P4441][NTf2] gave essentially identical results for different substrates in single-batch reactions, prolonged use of the catalyst in repeated reaction cycles lead to a quick drop-off in catalyst activity in [P4441][NTf2], but a continuous, quant. conversion in [N4441][NTf2].

European Journal of Inorganic Chemistry published new progress about Adsorption. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Saglik, Begum Nurpelin published the artcileDesign, synthesis, and structure-activity relationships of thiazole analogs as anticholinesterase agents for Alzheimer’s disease, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is thiazolylhydrazone preparation ADME mol docking anticholinesterase inhibitor Alzheimer disease; ADME parameters; Alzheimer’s disease; anticholinesterase enzyme activity; molecular docking; thiazole.

In this study, new thiazolylhydrazone derivatives I (R1 = H, OH, OMe; R2 = H, OH, OMe; R3 = H, OH, OMe; R4 = H, OMe; R2R3 = -OCH2O-) were designed and synthesized based on the cholinergic hypothesis. The ADME (absorption, distribution, metabolism, elimination) parameters of the synthesized compounds I were predicted by using QikProp 4.8 software. It was concluded that all compounds I presented satisfactory drug-like characteristics. Furthermore, their inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro were also tested by modified the Ellman spectrophotometric method. According to the results, all compounds I showed a weak inhibitory effect on BChE. On the other hand, most of the compounds I [R1 = R3 = R4 = H, R2 = OH (II); R1 = R2 = R4 = H, R3 = OH (III); R2 = R3 = R4 = H, R1 = OMe; R1 = R3 = R4 = H, R2 = OMe (IV); R1 = R4 = H, R2 = R3 = OMe (V); R1 = R4 = H, R2 = OH, R3 = OMe (VI); R1 = OH, R2 = R3 = H, R4 = OMe] had a certain AChE inhibitory activity, and the IC50 values of them were calculated as 0.063 ± 0.003, 0.056 ± 0.002, 0.147 ± 0.006, 0.040 ± 0.001, 0.031 ± 0.001, 0.028 ± 0.001, and 0.138 ± 0.005μM, resp. Among these derivatives, compound VI was found to be the most active agent in the series with an IC50 value of 0.028 ± 0.001μM, which indicated an inhibition profile at a similar rate as the reference drug, donepezil. The potential binding modes of compounds II, III, IV, V, and VI with AChE were investigated and compared with each other by the mol. docking studies. The results showed that these compounds were strongly bound up with the AChE enzyme active site with the optimal conformations.

Molecules published new progress about Absorption. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sasanam, Sirinapa published the artcileProperties and volatile profile of process flavorings prepared from D-xylose with glycine, alanine or valine by direct extrusion method, COA of Formula: C13H16O, the main research area is xylose glycine alanine valine flavoring.

This study investigated the production of process flavorings by direct extrusion method using a model system consisted of 80(weight/weight) D-xylose and glycine, alanine, or valine at 20(weight/weight). The extruder′s barrel temperatures were controlled at 65, 80, and 50 °C. The aroma compounds in the obtained products were analyzed by gas chromatog.-mass-spectrometry (GC-MS). Some properties relevant for food application including solubility, water absorption index, and oil absorption capacity were also determined Characteristics and color profiles of the extruded flavorings were similar to the process flavorings obtained by conventional method (reflux method). Process flavorings using valine presented the highest L* value (lightness, 59.6), water absorption index, water solubility index, and oil absorption capacity at 3.26 and 1.76 g/g sample, and 2.72 g oil/g, resp. Use of glycine resulted in the highest frequency of just-about-right for the taste (60), while alanine gave the highest frequency for odor (53.3). The extruded flavorings exhibited sweet, sour, and meaty flavor with 13 and 12 volatile compounds from glycine and alanine. When valine, the higher mol. weight amino acid in the bitter group was used, 37 volatiles with more complex flavor profiles were found, among of which, the compound 5-methyl-2-phenylhex-2-enal, which exhibits a chocolate odor, was also present. Sweet and meaty process flavorings could be produced by direct extrusion using D-xylose and glycine, alanine, and valine, with low moisture content at only 5by weight The information obtained about their phys., taste and sensory properties, volatile profiles, are beneficial for further use in industrial applications.

Food Bioscience published new progress about Absorption. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, COA of Formula: C13H16O.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem