Tag: M.W=150-200

Dabiri, Minoo published the artcilePalladium Catalyzed Cross-Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2-b]quinazolinone, Name: 2,3-Dimethoxybenzaldehyde, the main research area is hydroxyisoindoloquinazolinone preparation palladium catalyzed cross dehydrogenative coupling annulation; cross dehydrogenative coupling cyclization arylquinazolinone aldehyde TBHP oxidant.

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramol. cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Addnl., the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-Bu hydroperoxide (TBHP) as the oxidant in good yield.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Name: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sheng, Min published the artcileSingle-Crystal Cobalt Phosphide Nanorods as a High-Performance Catalyst for Reductive Amination of Carbonyl Compounds, Related Products of isoquinoline, the main research area is cobalt phosphide nanorod preparation surface structure; aldehyde ammonia cobalt phosphide nanocatalyst reductive amination green chem; ketone ammonium acetate cobalt phosphide reductive amination green chem; primary amine preparation.

Herein, the successful synthesis of single-crystal cobalt phosphide nanorods (Co2P NRs) containing coordinatively unsaturated Co-Co active sites, which serve as a new class of air-stable, highly active, and reusable heterogeneous catalysts for the reductive amination of carbonyl compounds was reported. The Co2P NR catalyst showed high activity for the transformation of a broad range of carbonyl compounds to their corresponding primary amines using an aqueous ammonia solution or ammonium acetate as a green amination reagent at 1 bar of H2 pressure; these conditions were far milder than previously reported. The air stability and high activity of the Co2P NRs was noteworthy, as conventional Co catalysts were air-sensitive (pyrophorous) and show no activity for this transformation under mild conditions. P-alloying was therefore of considerable importance for nanoengineering air-stable and highly active non-noble-metal catalysts for organic synthesis.

JACS Au published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhu, Fuyuan published the artcileI2 Promoted Synthesis of 2-Aminothiadiazoles Employing KSCN as a Sulfur Source Under Metal-Free Conditions, Category: isoquinoline, the main research area is aminothiadiazole preparation; aldehyde toluenesulfonyl hydrazide potassium thiocyanate three component cyclization.

A new three-component strategy from aldehydes RCHO (R = 4-methylphenyl, furan-2-yl, naphthalen-1-yl, styryl, etc.), p-toluenesulfonyl hydrazide and potassium thiocyanate for the synthesis of 2-aminothiadiazoles promoted by I2 under metal-free conditions has been described. Potassium thiocyanate was used as an odorless and low-toxicity sulfur source. A wide range of aromatic aldehydes can smoothly undergo the three-component cyclization reaction under the optimized conditions to give the corresponding products in moderate to good yields.

European Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Piper, Stefan published the artcileDirect aminoalkylation of α-branched aldehydes with in situ generated glycine cation equivalents, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is aminoalkylation aldehyde glycine cation equivalent; butyrolactone amino preparation; aminobutanediol alkyl preparation.

The efficient synthesis of β-formyl-α-aminocarboxylates by direct aminoalkylation of aldehydes with in situ generated ternary iminium salts from inexpensive starting materials is described. These compounds are easily transformed into α-amino-β,β-dialkyl-γ-butyrolactones and α,α-dialkyl-β-dialkylamino-butane-1,4-diols and can be used as versatile building blocks.

Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Safety of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Limouzadeh, Atefeh published the artcileNiFe2O4@SiO2PrA/PC-Ni(II) as a highly efficient catalyst for microwave promoted one pot synthesis of tetra substituted imidazoles, Synthetic Route of 86-51-1, the main research area is iron nickel oxide silica nickel phthalocyanine composite preparation catalyst; thermal stability iron nickel oxide silica nickel phthalocyanine; nanoparticle magnetization iron nickel oxide silica nickel phthalocyanine.

A simple and practical microwave irradiation synthetic strategy for preparation of catalyst nanostructured NiFe2O4@SiO2PrA/PC-Ni(II) was developed. The preparation of imidazole derivatives by using this catalyst in the reaction medium is much easier, faster, higher yields, simple separation of products and pure products. The structure of NiFe2O4@SiO2PrA/PC-Ni(II) was characterized by various analyses such as Fourier transform IR spectroscopy (FT-IR), X-ray diffraction (XRD), SEM, magnetic properties by vibrating sample magnetometer (VSM) and thermogravimetric anal. (TGA). The pure products were identified and characterized by phys. and spectroscopic data such as m.p., IR and 1H NMR techniques.

Journal of Coordination Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Popiolek, Lukasz published the artcileSynthesis and in vitro bioactivity study of new hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is aryl hydrazone preparation antitumor antimicrobial lipophilicity renal adenocarcinoma; 769-P cell line; Antimicrobial activity; Antiproliferative activity; COX-2; HepG2 cell line; Hydrazide-hydrazone; MBC; MIC; MTT assay; Vero cell line.

In this study 14 novel hydrazide-hydrazones of 5-bromo-2-iodobenzoic acid (3-16) were synthesized on the basis of condensation reaction. The chem. structure of obtained derivatives was established on the basis of spectral data (1H NMR and 13C NMR) and the lipophilicity of synthesized mols. was determined with the use of RP-HPTLC chromatog. Synthesized hydrazide-hydrazones (3-16) were subjected to in vitro cytotoxicity assay and antimicrobial activity anal. against a panel of bacteria and fungi. Among newly synthesized derivatives (3-16), compound 5 was characterized by high, selective and the most diverse cytotoxicity to the cancer cell lines. Mols. 7 and 9 which were substituted with a nitro group in the Ph ring also exhibited very significant inhibitory effect in the tumor cells and they were very selective. Similarly, compound 13 showed high antiproliferative activity against both cancer cell lines (769-P, HepG2) with satisfactory selectivity. In turn, mol. 8 was characterized by lower inhibitory effect in tumor cells but high selectivity. Derivative 16 proved to be toxic mainly to 769-P cells plausibly by the inhibition of COX-2 mediated signalling pathway. In summary, the introduction of chloro substituent or nitro group to the mol. proved to be most advantageous, providing high cytotoxicity and selectivity to tumor cells. However, the presence of indole scaffold appeared to be responsible for COX-2 inhibitory effect. Some of synthesized hydrazide-hydrazones possessed also moderate antimicrobial activity against a panel of microorganisms.

Biomedicine & Pharmacotherapy published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Baicun published the artcileDiscovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma, HPLC of Formula: 86-51-1, the main research area is quinoline amino benzoylhydrazide preparation diastereoselective cytoplasmic vacuolation paraptosis docking; 4-(Quinoline-4-amino) Benzoylhydrazide; Cytoplasmic vacuolation; Hepatocellular Carcinoma; Nur77; Paraptosis.

A series of 4-(quinoline-4-amino) benzoylhydrazide derivatives I (R = Ph, 3-bromo-4-methoxyphenyl, 3-bromothiophene-2-yl, 2-chloropyridin-3-yl, etc.) was synthesized and evaluated for their anti-HCC activity and binding affinity to Nur77 in vitro. Compound I (R = pyridin-4-yl) emerged as the best Nur77 binder (KD = 1.17μM) and has potentially selective cytotoxicity to HCC cells. Mechanistically, I (R = pyridin-4-yl) extensively induced caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. Moreover, I (R = pyridin-4-yl) exhibited an effective xenograft tumor inhibition by modulating Nur77-dependent cytoplasmic vacuolation and paraptosis. This paper is the first to disclose that chemotherapeutic agents targeting Nur77-mediated cytoplasmic vacuolization and paraptosis may provide a promising strategy to combat HCC that frequently evade the apoptosis program.

Bioorganic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, HPLC of Formula: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Fengming published the artcileDesign, synthesis, and biological evaluation of (E)-N’-substituted-4-((4-pyridylpyrimidin-2-yl)amino)benzohydrazide derivatives as novel potential CDK9 inhibitors, Formula: C9H10O3, the main research area is pyridylpyrimidinyl benzohydrazide preparation antitumor HIV inhibitor mol docking.

In a continuing effort to develop new CDK9 inhibitors endowed with good anticancer activity, a series of new benzene carbohydrazide derivatives I (R = pyridin-2-yl, pyridin-3-yl, pyridin-4-yl; R 1 = n-Pr, 4-methylphenyl, thiophen-2-yl, etc.) bearing a (pyridyl pyrimidin-2-yl)amino moiety in position-4 of the Ph ring was designed and synthesized. This work reports the preparation of benzene carbohydrazide derivatives I, their inhibition effect on HIV-1 transcription, and the preliminary structure-activity relationships. Compound I (R = pyridin-2-yl, R 1 = 4-methoxyphenyl (II)) was found to be the most potent CDK9 inhibitor and exhibited excellent anti-proliferative activities against cancer cells (A375, A549, HepG2, and MCF-7) but was less toxic to normal cells (MCF-10A and HaCaT). Further bioassays indicated that compound II could induce the apoptosis of cancer cells, which contributes to its antitumor effects. Finally, the mol. docking studies are performed to predict the binding mode of 9h at the ATP binding site of CDK9 and identify the essential amino acids responsible for the interactions.

Arabian Journal of Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Koli, Papita published the artcileStructure-Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer, Category: isoquinoline, the main research area is alkyl kojylmethane aryl preparation human antitumor SAR docking.

A series of (alkyl/aryl)kojylmethane (IKM) derivatives I [R = 4-HOC6H4, 2-pyrrolyl, 3-indolyl, etc.; R1 = n-Bu, Ph, 2-naphthyl, etc.] was synthesized using a multicomponent one-pot reaction under solvent-free condition using a heterogeneous catalyst. The synthesized compounds were screened against breast cancer cell lines MDA-MB-231, MCF7, and T47D. The structure-activity relationship revealed that IKM synthesized from aliphatic aldehydes were active against all three cell lines and showed IC50 value of 0.15μM-3.93μM. IKM synthesized from aromatic aldehydes having electron-donating groups specifically inhibited the proliferation of the MDA-MB-231 cell line. The effect of various substituted indoles was also studied and observed that compound I [R = 5-CN-indol-3-yl, R1 = Ph] synthesized from 5-cyanoindole, specifically inhibited T47D cell line proliferation. Compound I [R = 3-indolyl, R1 = n-heptyl] synthesized from kojic acid, indole and octanal was found to be most potent with IC50 values of 0.21, 0.15, and 3.45μM against MDA-MB-231, MCF7, and T47D, resp.

ChemistrySelect published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shabalala, Nhlanhla Gracious published the artcileCatalyst-free synthesis of novel isopropyl 2-amino-7,7-dimethyl-4-(aryl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives in aqueous ethanol under ultrasound irradiation, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is isopropyl amino dimethyl aryl oxo tetrahydrochromene carboxylate green preparation; aldehyde isopropyl cyanoacetate dimedone three component ultrasound.

A series of 2-amino-7,7-dimethyl-4-(aryl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate derivatives I [R = n-Bu, 2-ClC6H4, 4-FC6H4, etc.] was reported via a simple, efficient and environmentally friendly protocol. This was achieved through a three-component reaction of chosen aliphatic and aromatic aldehydes with iso-Pr cyanoacetate and 5,5-dimethyl-1,3-cyclohexanedione in aqueous ethanol under ultrasound irradn with excellent yields (95-99%) for rapid reaction times (5-15 min) at room temperature This method avoided the use of a catalyst, volatile organic solvents and column chromatog. The present method gave a 95% atom economy and 100% of carbon efficiency.

Chemical Data Collections published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem