Tag: M.W=150-200

Ceballos, Liena published the artcileOptimization of a HS-SPME/GC-MS method for determination of volatile compounds in some Cuban unifloral honeys, Name: 5-Methyl-2-phenylhex-2-enal, the main research area is honey volatile compound HS SPME GC MS Cuba.

A headspace (HS)/solid phase microextraction (SPME)/gas chromatog.-mass spectrometry (GC-MS) method was developed to determine the profiles of volatile compounds from three Cuban unifloral honeys: Turbina corymbosa (L.) Raf., Ipomoea triloba L. and Gouania polygama (Jacq.) Urb. The optimization of the extraction conditions was carried out by response surface methodol. The anal. conditions of the optimized HS-SPME method were: 65 μm PDMS/DVB fiber, 6 g honey, 3 mL water and 20% weight/weight sodium chloride, 20 min for pre-extraction, 30 min for extraction at 60C and 4 min for GC desorption. The GC-MS anal. allowed the identification of 181 volatile compounds in these honeys. Possible markers for the floral classification of honeys were for the T. corymbosa type: 4-Me methoxysalicylate, trans-pinocarveol, chavicol, Me anisate, trans-α-bergamotene and α-bisabolol. In I. triloba honey, 2,5,5-trimethyl-3-tetrahydrofuranone and 1,2-diphenylethanol were found, while 4-methyl-1-pentanol and isopentyl acetate were only present in G. polygama honey. With the use of the HS-SPME method in combination with multivariate anal. techniques such as Principal Component Anal. and K-nearest neighbor, it was possible to discriminate the different honeys according to their floral origin.

Journal of Food Quality published new progress about Apis mellifera. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Name: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yao, Peiyuan published the artcileImine Reductase-Catalyzed Enantioselective Reduction of Bulky α,β-Unsaturated Imines en Route to a Pharmaceutically Important Morphinan Skeleton, Name: 4-Methoxyphenylacetic acid, the main research area is imine reductase enantioselective reduction imine morphinan skeleton.

The morphinan skeleton is an important sub-structure in many medicines such as dextromethorphan, and can be constructed from 1-benzyl-1,2,3,4,5,6,7,8-octahydroisoquinoline (1-benzyl-OHIQ) derivatives 1-Benzyl-3,4,5,6,7,8-hexahydroisoquinolines (1-benzyl-HHIQs), the precursors of 1-benzyl-OHIQs, constitute a type of bulky α, β-unsaturated imines. Until now, the application of imine reductases (IREDs) to α, β-unsaturated imines has only rarely been reported. In this study, through evaluation of 48 IREDs, both enantiomers of 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline (1-(4-methoxybenzyl)-OHIQ) were obtained in high yield and excellent optical purity. Among the enzymes, the most steric hindrance-tolerant IRED from Sandarearacinus amylolyticus (IR40) was able to convert various Ph substituted 1-benzyl-HHIQ to the corresponding 1-benzyl-OHIQ derivatives with excellent enantiomeric excess. These results provide an effective route to synthesize these important compounds via enantioselective reduction of bulky α, β-unsaturated imine precursors, which can be readily prepared from 2-(1-cyclohexenyl)ethylamine and corresponding aryl acetic acids.

Advanced Synthesis & Catalysis published new progress about Enzyme kinetics. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Jiaqi published the artcileABNO-Catalyzed Aerobic Oxidative Synthesis of 2-Substituted 4H-3,1-Benzoxazines and Quinazolines, Application In Synthesis of 1205-17-0, the main research area is cascade aerobic oxidative cyclization aldehyde aminobenzyl alc aminobenzylamine; ABNO catalysis cascade aerobic oxidative cyclization; benzoxazine quinazoline preparation green chem.

A new transition-metal-free 9-azabicyclo[3.3.1]nonan-N-oxyl (ABNO) catalyzed aerobic oxidative synthesis of 2-substituted 4H-3,1-benzoxazines and quinazolines has been developed through cascade reaction of aldehydes with 2-aminobenzyl alcs. and 2-aminobenzylamines, resp. Under the optimal reaction conditions, the two kinds of heterocycles were obtained in 72-97% isolated yield.

European Journal of Organic Chemistry published new progress about Green chemistry. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fu, Xufeng published the artcileDi-(2-ethylhexyl) phthalate exposure induces female reproductive toxicity and alters the intestinal microbiota community structure and fecal metabolite profile in mice, Application In Synthesis of 104-01-8, the main research area is DEHP reproductive toxicity intestinal microbiota community fecal metabolite; DEHP; female reproductive toxicity; intestinal microbiota; metabolite profile.

Di-(2-ethylhexyl) phthalate (DEHP) is one of the most commonly used plasticizers, and it is widely applied in various plastic products. DEHP is an endocrine-disrupting chem. (EDC) that has been shown to disrupt the function of reproductive system in females. Although many studies have shown that DEHP potentially causes female reproductive toxicity, including depletion of the primordial follicle and decreased sex hormone production, the specific mechanisms by which DEHP affects female reproduction remain unknown. In recent years, research focused on the intestinal flora has provided an idea to eliminate our confusion, and gut bacterial dysbiosis may contribute to female reproductive toxicity. In the present study, the feces of DEHP-exposed mice were collected and analyzed using 16S rRNA amplicon sequencing and untargeted global metabolite profiling of metabolomics. DEHP obviously causes reproductive toxicity, including the ovarian organ coefficient, estradiol level, histol. features of the ovary and estrus. Furthermore, DEHP exposure alters the structure of the intestinal microbiota community and fecal metabolite profile in mice, suggesting that the reproductive toxicity may be caused by gut bacterial dysbiosis and altered metabolites, such as changes in the levels of short-chain fatty acid (SCFA). Addnl., it is well known that changes in gut microbiota and fecal metabolites cause inflammation and tissue oxidative stress, expectedly, we found oxidative stress in the ovary and systemic inflammation in DEHP exposed mice. Thus, based on our findings, DEHP exposure may cause gut bacterial dysbiosis and altered metabolite profiles, particularly SCFA profiles, leading to oxidative stress in the ovary and systemic inflammation to ultimately induce female reproductive toxicity.

Environmental Toxicology published new progress about Actinobacteria. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tripathi, Avanish published the artcileDesign and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer’s disease, SDS of cas: 86-51-1, the main research area is oxadiazole preparation Alzheimer disease docking antioxidant pharmacokinetic cholinesterase inhibitor; Acetylcholinesterase (AChE); Alzheimer’s disease; Aβ aggregation; Molecular hybridization; Multi-functional agents; β-Secretase-1 (BACE-1).

The diverse nature of Alzheimer’s disease (AD) has prompted researchers to develop multi-functional agents. Synthesized mol. hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles I (R = H, 3-Me, 2,4-dihydroxy, 3,4,5-trimethoxy, etc.) were designed. Biol. activities of synthesized compounds suggested significant and balanced inhibitory potential against target enzymes. In particular, compound I (R = 2,4-difluoro (A)) containing 2,4-difluoro substitution at terminal Ph ring considered as most potential lead with inhibition of acetylcholinesterase (hAChE, IC50 = 0.054 μM), butyrylcholinesterase (hBChE, IC50 = 0.787 μM) and beta-secretase-1 (hBACE-1, IC50 = 0.098 μM). The enzyme kinetics study of (A) against hAChE suggested a mixed type of inhibition (Ki = 0.030 μM). Also, I (R = 4-bromo) and (A) showed significant displacement of propidium iodide from the peripheral anionic site (PAS) of hAChE, excellent blood-brain barrier (BBB) permeability in parallel artificial membrane permeation assay (PAMPA), and neuroprotective ability against SH-SY5Y neuroblastoma cell lines. Further, (A) also exhibited anti-Aβ aggregation activity in self- and AChE-induced thioflavin T assay, which was ascertained by morphol. characterization by at. force microscopy (AFM). Moreover, in vivo behavioral studies signified learning and memory improvement by compound (A) in scopolamine- and Aβ-induced cognitive dysfunctions performed on Y-maze and Morris water maze. The ex vivo studies suggested decreased AChE activity and antioxidant potential of compound (A), with good oral absorption characteristics ascertained by pharmacokinetic studies.

European Journal of Medicinal Chemistry published new progress about Acute toxicity. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, SDS of cas: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sharma, Piyoosh published the artcileDesign and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer’s disease, Application In Synthesis of 86-51-1, the main research area is phenylmethylidene benzyl piperidinamine preparation docking acetylcholinesterase secretase inhibition SAR; dibenzylpiperidinamine preparation docking acetylcholinesterase secretase inhibition SAR; Acetylcholinesterase (AChE); Alzheimer’s disease; Aβ aggregation; Multitarget-directed ligands; Structure-based drug design; β-Secretase-1 (BACE-1).

A series of N-benzylpiperidine analogs I and II [R = H, 4-F, 2,3-(MeO)2, etc.] were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and β-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. Among the tested inhibitors, I and II [R = 4-O2N, 4-F3C] presented the most significant and balanced inhibition against both the targets. Compounds I [R = 4-O2N, 4-F3C] exhibited high brain permeability in the PAMPA-BBB assay, significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE and were devoid of neurotoxicity towards SH-SY5Y neuroblastoma cell lines up to the maximum tested concentration of 80 μM. Meanwhile, both these compounds inhibited self- and AChE-induced Aβ aggregation in thioflavin T assay, which was also re-affirmed by morphol. characterization of Aβ aggregates using at. force microscopy (AFM). Moreover, I [R = 4-O2N, 4-F3C] ameliorated the scopolamine-induced cognitive impairment in elevated plus and Y-maze experiments Ex-vivo and biochem. anal. established the brain AChE inhibitory potential and antioxidant properties of these compounds Further, improvement in Aβ1-42-induced cognitive impairment was also observed by compound I [R = 4-F3C] in the Morris water maze experiment with significant oral absorption characteristics ascertained by the pharmacokinetic studies.

European Journal of Medicinal Chemistry published new progress about Acute toxicity. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Charitos, Georgios published the artcileSynthesis and anticancer activity of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives, Name: 4-Methoxyphenylacetic acid, the main research area is triazolothiadiazole benzyl aminosulfonyl preparation cytostatic cytotoxic antineoplastic; triazole amino mercapto condensation aromatic arylalkanoic acid.

A series of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I [R = Ph, 4-MeOC6H4CH2, PhCH:CH, Ph(CH2)3, 4-pyridinyl, etc.] has been designed, synthesized and evaluated as potential anticancer agents. The strategy of combining two chem. different but pharmacol. compatible mols. (the 1,2,4-triazole and 1,3,4-thiadiazole) in one frame has been emphasized. Several of the newly synthesized 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles I showed substantial cytostatic and cytotoxic antineoplastic activity in vitro, while they have produced relatively low acute toxicities in vivo, giving potentially high therapeutic ratios. In silico screening has revealed several protein targets including apoptotic protease-activating factor 1 (APAF1) and tyrosine-protein kinase HCK which may be involved in the biol. activities of active analogs.

Arabian Journal of Chemistry published new progress about Acute toxicity. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Name: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zarini, Daniele published the artcileAre In Silico Approaches Applicable As a First Step for the Prediction of e-Liquid Toxicity in e-Cigarettes?, Synthetic Route of 21834-92-4, the main research area is toxicity electronic cigarette liquid QSAR model.

Recent studies have raised concerns about e-cigarette liquid inhalation toxicity by reporting the presence of chems. with European Union CLP toxicity classification. In this scenario, the regulatory context is still developing and is not yet up to date with vaping current reality. Due to the paucity of toxicol. studies, robust data regarding which components in tent. In this study we applied computational methods for studied chems. as a useful tool for predicting the acute toxicity of chems. contained in e-liquids The purpose of t the potential health concerns associated with e-liquid ingredients, (b) to prioritize e-liquid ingredients by calculating the e-tox index, and (c) to estimate acute toxicity of e-liquid mixtures QSAR models were generated using QSARINS software to fill the acute toxicity data gap of 264 e-liquid ingredients. As a second step, the potential acute toxicity of e-liquids mixtures was evaluated. Our preliminary data suggest that a computational approa serve as a roadmap to enable regulatory bodies to better regulate e-liquid composition and to contribute to consumer health protection.

Chemical Research in Toxicology published new progress about Acute toxicity. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Synthetic Route of 21834-92-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Colonges, Kelly published the artcileIntegration of GWAS, metabolomics, and sensorial analyses to reveal novel metabolic pathways involved in cocoa fruity aroma GWAS of fruity aroma in Theobroma cacao, Category: isoquinoline, the main research area is Theobroma GWAS metabolomics fruity aroma protein sugar degradation; Aroma; Biochemical bases; Cocoa; Fruity note; GWAS; Genetic bases.

Nacional is a variety of cocoa tree known for its “”Arriba”” aroma characterised mainly by fruity, floral, and spicy aromatic notes. In this study, the genetic basis of the fruity aroma of modern Nacional cocoa was investigated. GWAS studies have been conducted on biochem. and sensorial fruity traits and allowed to identify a large number of association zones. These areas are linked to both the volatile compounds known to provide fruity flavours and present in the beans before and after roasting, and to the fruity notes detected by sensorial anal. Five main metabolic pathways were identified as involved in the fruity traits of the Nacional population: the protein degradation pathway, the sugar degradation pathway, the fatty acid degradation pathway, the monoterpene pathway, and the L-phenylalanine pathway. Candidate genes involved in the biosynthetic pathways of volatile compounds identified in association areas were detected for a large number of associations

Plant Physiology and Biochemistry (Issy-les-Moulineaux, France) published new progress about Analysis (GWAS). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lou, X. W. published the artcileThe change of volatile compounds of two kinds of vinasse-cured ducks during processing, Product Details of C13H16O, the main research area is duck vinasse wet dry curing butenal hexane moisture flavor.

Vinasse-cured duck was processed by boiling, salting, and vinasse-dry-curing or vinasse-wet-curing. Volatile compounds, moisture contents, reducing sugars, and thiobarbituric acid reactive substances (TBARS) values during processing were determined Reducing sugars decreased during boiling and increased after vinasse-curing. TBARS values increased throughout the processing. The volatiles of ducks during processing and vinasse-curing agents (dry vinasse and vinasse sauce) were 125 compounds The first principal component (PC1) belonged to the flavor of cooked duck, whereas the second principal component (PC2) represented the flavor of yellow rice wine. The 66.49 and 29.61% of typical aroma of vinasse-dry-cured product were from dry vinasse and lipid oxidation, resp., whereas the 75.58 and 21.89% of aroma of vinasse-wet-cured product were from vinasse sauce and lipid oxidation, resp. Lipid oxidation products increased after boiling, whereas salting promoted their release. Compared with vinasse-wet-cured duck, vinasse-dry-cured product presented richer aroma of lipid oxidation and weaker flavor of vinasse-curing agents. Besides, protein denaturation which was caused by ethanol could influence the retention and release of flavor. In conclusion, two kinds of vinasse-curing methods influenced the characteristic volatiles of products and their generation during processing.

Poultry Science published new progress about Anas domesticus. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Product Details of C13H16O.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem