Tag: M.W:200-300

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Oriental Journal of Chemistry called Synthesis, spectroscopic, electrochemical and antibacterial activities of mono- and homobi-nuclear of Ru(II) complexes with a triazolate bridging ligand, Author is El-Gahami, Mohamed A.; Albishri, Hassan M., which mentions a compound: 1671-88-1, SMILESS is NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3, Molecular C12H10N6, Electric Literature of C12H10N6.

Mono- and homodinuclear Ru(II) complexes were prepared by the reaction of [Ru(bipy)2Cl2]H2O with 4-amino-3,5-di(2-pyridyl)-4H-1,2,4-triazole (adapt); 4-(4-pyridyl)-3,5-di(2-pyridyl)-4H-1,2,4-triazole (Pydpt), and 4-(4-methylphenyl)-3,5-di(2-pyridyl)-4H-1,2,4-triazole (mpdpt). The products were characterized by elemental anal., IR, electronic and 1H NMR spectral however molar conductance and their redox chem. was studied using cyclic voltammetry. An octahedral structure was tentatively proposed for the new complexes. All the complexes exhibit reversible, metal-based oxidation processes and reversible, bipy-based reduction process in the potential window studied. The metal complexes are more active than the parent ligands and exhibit mild to moderate antibacterial activity.

From this literature《Synthesis, spectroscopic, electrochemical and antibacterial activities of mono- and homobi-nuclear of Ru(II) complexes with a triazolate bridging ligand》,we know some information about this compound(1671-88-1)Electric Literature of C12H10N6, but this is not all information, there are many literatures related to this compound(1671-88-1).

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1671-88-1, is researched, SMILESS is NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3, Molecular C12H10N6Journal, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) called Symmetrically and unsymmetrically 3,6-disubstituted 1,2-dihydro-1,2,4,5-tetrazines including their conversion into the corresponding tetrazines and 3,5-disubstituted 4-amino-1,2,4-triazoles, Author is Bowie, R. A.; Gardner, M. D.; Neilson, D. G.; Watson, K. M.; Mahmood, S.; Ridd, V., the main research direction is PMR dihydrotetrazine aminotriazole; tetrazine dihydrotetrazine oxidation; aminotriazole dihydrotetrazine rearrangement; triazole amino PMR.Recommanded Product: 1671-88-1.

3,6-Disubstituted 1,2-dihydro-1,2,4,5-tetrazines were prepared by the action of H2NNH2.H2O on nitriles in the presence of S or on amidinium chlorides; the dihydrotetrazines were oxidized to the corresponding tetrazines and rearranged by heat or acid to 3,5-disubstituted 4-amino-1,2,4-triazoles. 1,2-Dihydro-1,2,4,5-tetrazines and 4-amino-1,2,4-triazoles were distinguished by PMR spectroscopy.

From this literature《Symmetrically and unsymmetrically 3,6-disubstituted 1,2-dihydro-1,2,4,5-tetrazines including their conversion into the corresponding tetrazines and 3,5-disubstituted 4-amino-1,2,4-triazoles》,we know some information about this compound(1671-88-1)Recommanded Product: 1671-88-1, but this is not all information, there are many literatures related to this compound(1671-88-1).

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Isoquinoline – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Nfor, Emmanuel N.; Asobo, Peter F.; Nenwa, Justin; Nfor, Oswald N.; Njapba, Julius N.; Njong, Romanus N.; Offiong, Offiong E. researched the compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine( cas:1671-88-1 ).Synthetic Route of C12H10N6.They published the article 《Nickel (II) and iron (II) complexes with azole derivatives: synthesis, crystal structures and antifungal activities》 about this compound( cas:1671-88-1 ) in International Journal of Inorganic Chemistry. Keywords: preparation crystal structure nickel iron aminopyridyltriazole phenylpyrazoleylpyridine complex; antifungal activity nickel iron aminopyridyltriazole phenylpyrazoleylpyridine complex. We’ll tell you more about this compound (cas:1671-88-1).

Two new complexes of nickel(II) with 4-amino-3,5-bis(pyridyl)-1,2,4-triazole (abpt) and iron(II) with 2-(3-phenyl-1H-pyrazole-5-yl) pyridine (phpzpy) were synthesized and characterized by elemental anal. and IR spectroscopy. The prepared complexes are [Ni(abpt)2(OH2)2](ClO4)2 (1) and [Fe(phpzpy)2(NCS)2] (2). The crystal structures of the complexes were determined by single crystal x-ray diffraction techniques. In the nickel and iron complexes, the ligands are coordinated through nitrogen atoms in bidentate manner. The ligands and their resp. complexes were tested for their antifungal activity against Aspergillus niger, Aspergillus flavus and Candida albicans. The complexes showed enhanced activities against the tested organisms compared to the ligands.

From this literature《Nickel (II) and iron (II) complexes with azole derivatives: synthesis, crystal structures and antifungal activities》,we know some information about this compound(1671-88-1)Synthetic Route of C12H10N6, but this is not all information, there are many literatures related to this compound(1671-88-1).

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Isoquinoline – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine(SMILESS: NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3,cas:1671-88-1) is researched.Reference of 1-Bromo-2-pentyne. The article 《Slow Magnetic Relaxation in Octahedral Cobalt(II) Field-Induced Single-Ion Magnet with Positive Axial and Large Rhombic Anisotropy》 in relation to this compound, is published in Inorganic Chemistry. Let’s take a look at the latest research on this compound (cas:1671-88-1).

Pseudooctahedral mononuclear cobalt(II) complex [Co(abpt)2(tcm)2] (1), where abpt = 4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole and tcm = tricyanomethanide anion, shows field-induced slow relaxation of magnetization with U = 86.2 K and large axial and rhombic single-ion zero-field-splitting parameters, D = +48(2) cm-1 and E/D = 0.27(2) (D = +53.7 cm-1 and E/D = 0.29 from ab initio CASSCF/NEVPT2 calculations), thus presenting a new example of a field-induced single-ion magnet with transversal magnetic anisotropy.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 123784-07-6, is researched, SMILESS is BrC1=CC=C(C2=NC=CC=C2)S1, Molecular C9H6BrNSJournal, Article, Chemistry – A European Journal called Water-Soluble Luminescent Cyclometalated Gold(III) Complexes with cis-Chelating Bis(N-Heterocyclic Carbene) Ligands: Synthesis and Photophysical Properties, Author is Hung, Faan-Fung; To, Wai-Pong; Zhang, Jing-Jing; Ma, Chensheng; Wong, Wai-Yeung; Che, Chi-Ming, the main research direction is water soluble luminescent cyclometalated gold chelating heterocyclic carbene preparation; thiazolylpyridine cyclometalated gold imidazolylidene carbene preparation crystal mol structure; photophys property electrochem redox cyclometalated gold chelating heterocyclic carbene; N-heterocyclic carbenes; cyclometalation; gold; luminescence; water chemistry.Computed Properties of C9H6BrNS.

A new class of cyclometalated AuIII complexes containing various bidentate C-deprotonated C-N and cis-chelating bis(N-heterocyclic carbene) (bis-NHC) ligands has been synthesized and characterized. These are the first examples of AuIII complexes supported by cis-chelating bis-NHC ligands. [Au(C-N)(bis-NHC)] complexes display emission in solutions under degassed condition at room temperature with emission maxima (λmax) at 498-633 nm and emission quantum yields of up to 10.1 %. The emissions are assigned to triplet intraligand (IL) π→π* transitions of C-N ligands. The AuIII complex containing a C-N (C-deprotonated naphthalene-substituted quinoline) ligand with extended π-conjugation exhibits prompt fluorescence and phosphorescence of comparable intensity with λmax at 454 and 611 nm resp. With sulfonate-functionalized bis-NHC ligand, four water-soluble luminescent AuIII complexes, including those displaying both fluorescence and phosphorescence, were prepared They show similar photophys. properties in water when compared with their counterparts in acetonitrile. The long phosphorescence lifetime of the water-soluble AuIII complex with C-deprotonated naphthalene-substituted quinoline ligand renders it to function as ratiometric sensor for oxygen. Inhibitory activity of one of these water-soluble AuIII complexes towards deubiquitinase (DUB) UCHL3 has been investigated; this complex also displayed a significant inhibitory activity with IC50 value of 0.15 μM.

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Jing; Shao, Chun-Fu; Bi, Yan; Yu, Wen-Jing published the article 《Hydrothermal Syntheses, Crystal Structures, and Fluorescent Properties of Zn(II) Coordination Complexes With 4-Amino-3,5-Bis(2-Pyridyl)-1,2,4-Triazole and Different Aromatic Dicarboxylic Acids》. Keywords: zinc aminopyridyltriazole aromatic dicarboxylate complex hydrothermal preparation crystal structure; luminescence zinc aminopyridyltriazole aromatic dicarboxylate complex.They researched the compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine( cas:1671-88-1 ).Quality Control of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1671-88-1) here.

Three new Zn(II) supramol. complexes {[Zn(2-bpt)(tp)(H2O)](H2O)}∞ (1), [Zn(2-bpt)2(Hpa)2] (2), and [Zn(2-bpt)2(H2O)2](Hip-NO2)2 (3) were synthesized under hydrothermal conditions by using 4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole (2-bpt) and Zn(OAc)2 with the presence of different aromatic dicarboxylic acids (H2tp = terephthalic acid, H2pa = phthalic acid, and H2i.p.-NO2 = 5-nitroisophthalic acid). Complex 1 shows a one-dimensional zigzag chain array, 2 represents a neutral mononuclear mol., and 3 consists of the cationic mononuclear coordination unit and Hip-NO2 anion. Notably, in complex 3, the H2i.p.-NO2 ligand is partly deprotonated to balance the charge and uncoordinated to the metal center. In all three structures, the low-dimensional coordination motifs are further extended to distinct two-dimensional or three-dimensional supramol. networks via H-bonding and/or π···π stacking interactions. Fluorescent properties for 1-3 also were studied in solid state at room temperature

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis, structure, spectral, redox properties and anti-cancer activity of Ruthenium(II) Arene complexes with substituted Triazole Ligands, published in 2021-12-01, which mentions a compound: 1671-88-1, mainly applied to cymene ruthenium pyridyltriazolylpyridine preparation crystal mol structure antitumor activity; arene ruthenium pyridyltriazolylpyridine complex preparation crystal mol structure antitumor, Recommanded Product: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine.

Three versatile half-sandwich ruthenium(II) p-cymene complexes bearing substituted triazole ligands exhibit promising cancer cell growth inhibition activity towards A549 lung adenocarcinoma and MDA-MB-231 breast adenocarcinoma cells. In this context, the triazole based phthalimide protected new ligand (2-(3, 5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione) (L1) was prepared Three ruthenium(II) p-cymene complexes [Ru(η6-p-cymene)(L1)Cl]Cl: [1]Cl, L1: (2-(3,5-di(pyridin-2-yl)-4H-1,2,4-triazol-4-yl)isoindoline-1,3-dione), [Ru(η6-p-cymene)(L2)Cl]Cl: [2]Cl and [Ru(η6-p-cymene)(L2)Cl](PF6): [2](PF6), L2 (2,2′-(4-(1H-pyrrol-1-yl)-4H-1,2,4-triazole-3,5-diyl)dipyridine) have been successfully synthesized and characterized by different spectral and anal. tools. Pyrrole protected substituted ruthenium complexes [2]Cl and [2](PF6) have been successfully identified structurally by single-crystal x-ray diffraction studies and confirmed the successful anion exchange. The redox properties of the ligands and the targeted metal complexes have been carefully examined Cellular staining, live-cell imaging and MTT assay have been performed for all the complexes. Authors have demonstrated that their synthesized ruthenium(II) p-cymene complexes are capable of inducing significant cytotoxicity in A549 lung cancer cell lines, with an IC50 values of 6.56 ± 0.31μM, 4.74 ± 0.2μM and 13.67 ± 0.64μM and in MDA-MB-231 breast cancer cell lines with an IC50 values of 1.13 ± 0.046μM, 0.36 ± 0.016μM and 11.32 ± 0.49μM for [1]Cl, [2]Cl and [2](PF6) resp.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

COA of Formula: C11H11NO3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about 5-Substituted analogs of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en-1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro. Author is Jaffar, Mohammed; Naylor, Matthew A.; Robertson, Naomi; Lockyer, Stacey D.; Phillips, Roger M.; Everett, Steven A.; Adams, Gerald E.; Stratford, Ian J..

A series of regioisomeric analogs of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en-1-ol (EO9, NSC 382459) with the hydroxymethyl and hydroxypropenyl substituents situated at either the 2- or the 3-position of the indole ring were synthesized. The compound lacking the 2-hydroxypropenyl substituent had similar properties to EO9 under both aerobic and hypoxic conditions against V79 cells and was more potent against a human tumor cell line (A549) than EO9. It was reduced by human DT-diaphorase (DTD) at more than double the rate of EO9, thus implicating the importance of the enzyme activation step. The compound lacking the 3-hydroxymethyl substituent was a better substrate for human DTD than EO9, yet exhibited lesser toxicity under both aerobic and hypoxic conditions. The toxicity of EO9 was attributed to a combination of the aziridinyl group and the leaving group properties of the 3-hydroxymethyl substituent. In general, compounds with a 5-methylaziridinyl moiety, such as EO8, exhibited substantially better hypoxia-selectivity due to much slower reduction by DTD (20-fold), thus reducing aerobic potency. All compounds had similar electron affinities, as indicated by their one-electron reduction potentials.

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Tuning the Spin States of Two Apical Iron(II) Ions in the Trigonal-Bipyramidal [{FeII(μ-bpt)3}2FeII3(μ3-O)]2+ Cations Through the Choice of Anions, published in 2010, which mentions a compound: 1671-88-1, mainly applied to crystal structure iron bispyridinyltriazolato oxo bridged pentanuclear cluster; iron bispyridinyltriazolato oxo bridged pentanuclear cluster preparation spin state; counterion control iron bispyridinyltriazolato oxo bridged pentanuclear spin state, Name: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine.

Pentanuclear [{FeII(μ-bpt)3}2FeII3(μ3-O)]2+ (Hbpt = 3,5-bis(2-pyridinyl)-1,2,4-triazole) complex salts were prepared with different counterions. The spin states of the apical Fe(2+) centers were tunable depending on the counterion. A [Fe2OCl6]2- counterion induced the high spin state in the pentanuclear cluster while SCN-/ClO4-/I- gave low spin states in the apical Fe centers. Crystal structures are reported for the 4 salts as solvates. The bpt- clusters were prepared from the 4-aminotriazole analog.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 42409-58-5, is researched, Molecular C6H7BrN2O, about Ortho-substituent effect promoted rapid cleavage of amide C-N bond under mild conditions, the main research direction is ortho substituent effect promoted rapid cleavage amide CN bond.SDS of cas: 42409-58-5.

This article reports the ortho-substituent effect on the cleavage of the amide C-N bond. In the structure of Nα-Phth-N-pyridinyl-amide, when the hydrogen atom in the 3-position of pyridine ring was replaced by alkoxy group, the amide C-N cleavage can take place in the 2-position of the pyridine ring. This transformation can proceed rapidly in methylamine ethanol solution under mild conditions to afford 2-amino-3-alkoxy pyridines.

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Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem