Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 42409-58-5, is researched, Molecular C6H7BrN2O, about Ortho-substituent effect promoted rapid cleavage of amide C-N bond under mild conditions, the main research direction is ortho substituent effect promoted rapid cleavage amide CN bond.SDS of cas: 42409-58-5.
This article reports the ortho-substituent effect on the cleavage of the amide C-N bond. In the structure of Nα-Phth-N-pyridinyl-amide, when the hydrogen atom in the 3-position of pyridine ring was replaced by alkoxy group, the amide C-N cleavage can take place in the 2-position of the pyridine ring. This transformation can proceed rapidly in methylamine ethanol solution under mild conditions to afford 2-amino-3-alkoxy pyridines.
Compound(42409-58-5)SDS of cas: 42409-58-5 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5-Bromo-3-methoxypyridin-2-amine), if you are interested, you can check out my other related articles.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem