Day: November 10, 2022

Porey, Arka published the artcileHydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides, COA of Formula: C9H10O3, the main research area is acylaminoalkyl ester hydroxyamide kinetic resolution nonracemic preparation; indenooxazinotriazolylidene catalyst oxidative kinetic resolution hydroxyamide cinnamaldehyde; NHCs; enantioselectivity; hydrogen bonding; kinetic resolution; β-hydroxy amides.

Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chem., material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alc. with a cinnamaldehyde in the presence of an N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.

Angewandte Chemie, International Edition published new progress about Enantioselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yao, Yu published the artcileUPLC-MS/MS method for the determination of the herb composition of Tangshen formula and the in vivo pharmacokinetics of its metabolites in rat plasma, SDS of cas: 104-01-8, the main research area is Tangshen formula herb plasma metabolite pharmacokinetics UPLC MS; LC-MS/MS; Thermo Q Exactive™ Plus Orbitrap™ mass spectrometer; chemical constituents; pharmacokinetics; traditional Chinese medicines.

Tangshen formula (TSF) is a traditional Chinese medicine composed of seven medicinal herbs including Astragalus membranaceus, Rehmannia glutinosa Libosch, Citrus aurantium L., etc. which is used to treat diabetic nephropathy III, IV qi and yin deficiency and stasis syndrome. Most of the studies on TSF are pharmacol. and pharmacodynamic experiments There are few basic studies on its chem. substances, and the effective constituents are not clear. To analyze the main chem. components of TSF and the absorbed components in rat plasma following oral administration based on liquid chromatog. tandem mass spectrometry (LC-MS/MS). Moreover, providing a rapid and valid anal. strategy for simultaneous determination of six components in rat plasma and use it in pharmacokinetic studies. A total of 132 components were identified in TSF, and 44 components were identified in rat plasma after oral TSF, 35 of which were prototype components and nine were metabolic components. A sensitive and reliable LC-MS/MS method was developed for simultaneous determination of six components in rat plasma. The intra-day and inter-day precision relative standard deviation (RSD) was lower than 15%; the accuracy of low, medium and high concentrations ranged from 80% to 120%. The recovery met the requirements and the RSD of the recoveries was less than 15%. A total of 132 components were identified in TSF. The LC-MS/MS quant. method for the simultaneous determination of morroniside, loganin, notoginsenoside R1, ginsenoside Re, ginsenoside Rb1 and astragaloside IV in rat plasma was established for the first time. The pharmacokinetic parameters are clarified, which can guide the clin. medication of TSF.

Phytochemical Analysis published new progress about Arthrogryposis-renal dysfunction-cholestasis syndrome. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jiang, Zheng-Meng published the artcileGreen and efficient extraction of different types of bioactive alkaloids using deep eutectic solvents, SDS of cas: 598-50-5, the main research area is Caulis Coptis Stephania Tetradium Sophora; bioactive alkaloid extraction deep eutectic solvent.

Deep eutectic solvents (DESs) have attracted increasing attention as eco-friendly and efficient alternatives to conventional organic solvents. In this study, five herbal medicines (HMs) including Caulis sinomenii, Coptis chinensis, Stephania tetrandra, Tetradium ruticarpum, and Sophora flavescens were selected for the first time to comprehensively evaluate the potential and effectiveness of DESs on the extraction of Morphinane, Protoberberine, Bisbenzylisoquinoline, Indole and Quinolizidine alkaloids, resp. A total of 75 types of binary or ternary DESs with different polarity, viscosity, pH, and solubilization abilities were tailored to screen a suitable DESs for extraction of morphinane alkaloids from Caulis sinomenii, and the extraction conditions were optimized using response surface methodol. (RSM) and artificial neural network hybridized with genetic algorithm (ANN-GA) for the first time. The results demonstrated that DESs were excellent solvents for extraction of alkaloids with superior efficiency to conventional extraction solvents. Moreover, both ANOVA and sensitivity anal. demonstrated that the most critical parameter for alkaloids extraction was water content in DESs. This study reveals the potential of eco-friendly DESs for applications involving the efficient extraction of bioactive alkaloids from natural sources.

Microchemical Journal published new progress about Coptis chinensis. 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, SDS of cas: 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kenia, Hasti published the artcileEthyl-4-(dimethylamino)-2-(4-methoxyphenyl) propanote as anxiolytic, anti-inflammatory and anti-bacterial agent, Synthetic Route of 104-01-8, the main research area is ethyl dimethylamino methoxyphenyl propanote preparation anxiolytic antipsychotic antidepressant antiinflammatory; antibacterial ethyl dimethylamino methoxyphenyl propanote preparation.

An improved process for the synthesis of ethyl-4-(dimethylamino)-2-(4-methoxyphenyl)propanote I was carried out by hydrolysis of 2-(4-methoxyphenyl)acetonitrile using sodium hydroxide to obtain 2-(4-methoxyphenyl)acetic acid which was then esterified with ethanol to obtain 2-(4-methoxyphenyl)acetate which on further Mannich reaction with paraformaldehyde and dimethylamine in presence of catalytic amount of tert-Bu ammonium bromide. Compound I was subjected to pharmacol. screening for anxiolytic activity by elevated plus maze test, open field test and motor co-ordination test by Rota rod. Compound I was also screened for in-vivo antipsychotic, in-vivo antidepressant, in-vitro anti-inflammatory activity by protein denaturation method and antibacterial activity by serial dilution method.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about Anti-inflammatory agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem