Porey, Arka published the artcileHydrogen-Bonding Assisted Catalytic Kinetic Resolution of Acyclic β-Hydroxy Amides, COA of Formula: C9H10O3, the main research area is acylaminoalkyl ester hydroxyamide kinetic resolution nonracemic preparation; indenooxazinotriazolylidene catalyst oxidative kinetic resolution hydroxyamide cinnamaldehyde; NHCs; enantioselectivity; hydrogen bonding; kinetic resolution; β-hydroxy amides.
Enantioenriched acyclic α-substituted β-hydroxy amides are valuable compounds in chem., material and medicinal sciences, but their enantioselective synthesis remains challenging. A catalytic kinetic resolution (KR) of such amides with selectivity factor(s) up to >200 is developed via enantioselective acylation of primary alc. with a cinnamaldehyde in the presence of an N-heterocyclic carbene. An enhanced selectivity for the catalytic KR process is realized using cyclic tertiary amine as base additive. Diastereomeric transition state models for the process are proposed to rationalize the origin of enantioselectivity.
Angewandte Chemie, International Edition published new progress about Enantioselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem