Month: November 2022

Ma, Zhuang published the artcileReusable Co-nanoparticles for general and selective N-alkylation of amines and ammonia with alcohols, SDS of cas: 5961-59-1, the main research area is doped carbon supported cobalt nanoparticle preparation; alkylated amine selective preparation; alc amine alkylation cobalt nanocatalyst; ammonia alc alkylation cobalt nanocatalyst.

A general cobalt-catalyzed N-alkylation of amines with alcs. by borrowing hydrogen methodol. to afford alkylated amines I [R = Pr-n, cyclohexyl, Ph, etc.; R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.] was reported. The optimal catalyst for this transformation was prepared by pyrolysis of a specific templated material, which was generated in situ by mixing cobalt salts, nitrogen ligands and colloidal silica and subsequent removal of silica. Applying this novel Co-nanoparticle-based material, >100 primary, secondary and tertiary amines including N-methylamines and selected drug mols. were conveniently prepared starting from inexpensive and easily accessible alcs. and amines or ammonia.

Chemical Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Ming published the artcileRoom temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is secondary amine preparation; aniline alc alkylation heterocyclic carbene manganese catalyst.

The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcs. by a bis-NHC manganese complex is presented. This system was applied to a large range of alcs. and anilines, including biol. relevant motifs and challenging methanol. Exptl. and computational studies suggest an outer-sphere mechanism for this NHC-Mn system.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Ming published the artcileRuthenium(II) complexes with N-heterocyclic carbene-phosphine ligands for the N-alkylation of amines with alcohols, COA of Formula: C8H11NO, the main research area is secondary arylamine preparation; amine alc alkylation ruthenium phosphine ligand catalyst.

Metal hydride complexes are key intermediates for N-alkylation of amines with alcs. by the borrowing hydrogen/hydrogen autotransfer (BH/HA) strategy. Reactivity tuning of metal hydride complexes could adjust the dehydrogenation of alcs. and the hydrogenation of imines. Herein we report ruthenium(II) complexes with hetero-bidentate N-heterocyclic carbene (NHC)-phosphine ligands, which realize smart pathway selection in the N-alkylated reaction via reactivity tuning of [Ru-H] species by hetero-bidentate ligands. In particular, complex I·BArF- with a Ph wingtip group and BArF- counter anion, is shown to be one of the most efficient pre-catalysts for this transformation (temperature is as low as 70°C, neat conditions and catalyst loading is as low as 0.25 mol%). A large variety of (hetero)aromatic amines and primary alcs. were efficiently converted into mono-N-alkylated amines in good to excellent isolated yields. Notably, aliphatic amines, challenging methanol and diamines could also be transformed into the desired products. Detailed control experiments and d. functional theory (DFT) calculations provide insights to understand the mechanism and the smart pathway selection via [Ru-H] species in this process.

Organic & Biomolecular Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Upadhyay, Rahul published the artcileV2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls, Synthetic Route of 86-51-1, the main research area is aldehyde ketone preparation green chem; alc alkylbenzene styrene selective oxidation vanadia titania catalyst.

The versatile application of different functional groups such as alcs. (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions has been reported. The method was successfully applied for the alc. oxidation, oxidative scission of styrenes, and benzylic C-H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30% aqueous), TBHP (70% aqueous), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol.

ChemCatChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kang, Qi-Kai published the artcileCatalytic SNAr Hydroxylation and Alkoxylation of Aryl Fluorides, Computed Properties of 151-10-0, the main research area is phenol preparation DFT mechanistic study; water aryl fluoride hydroxylation rhodium catalyst; ester preparation DFT mechanistic study; aryl fluoride alc alkoxylation rhodium catalyst; C−O bond formation; Meisenheimer-type intermediate; rhodium; η6-coordination.

A reliable method for accessing phenols ArOH (Ar = C6H5, 4-CH3OC6H4, 9H-fluoren-2-yl, etc.) and Ph alkyl ethers Ar1OR (Ar1 = 4-CH3C6H4, 9H-fluoren-2-yl, 1-methyl-2-oxo-2,3-dihydro-1H-indol-5-yl, etc.; R = Me, cyclohexylmethyl, oxan-4-yl, etc.) via catalytic SnAr reactions has been described. The method is applicable to a broad array of electron-rich and neutral aryl fluorides ArF and Ar1F, which are inert under classical SnAr conditions. Although the mechanism of SNAr reactions involving metal arene complexes is hypothesized to involve a stepwise pathway (addition followed by elimination), exptl. data that support this hypothesis is still under exploration. Mechanistic studies and DFT calculations suggest either a stepwise or stepwise-like energy profile. Notably, a rhodium η5-cyclohexadienyl complex intermediate with an sp3-hybridized carbon bearing both a nucleophile and a leaving group was isolated.

Angewandte Chemie, International Edition published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ide, Takafumi published the artcileLate-Stage Intermolecular Allylic C-H Amination, SDS of cas: 598-50-5, the main research area is trichloroethoxy sulfamyl olefin preparation allylic amination regioselective chemoselective diastereoselective.

A sustainable manganese perchlorophthalocyanine catalyst [MnIII(ClPc)]2 achieved selective, preparative intermol. allylic C-H amination of 32 cyclic and linear compounds, including ones housing basic amines and competing sites for allylic, ethereal and benzylic amination were reported. Mechanistic studies supported that the high selectivity of [MnIII(ClPc)] may be attributed to its electrophilic, bulky nature and stepwise amination mechanism. Late-stage amination was demonstrated on five distinct classes of natural products generally with >20:1 site-, regio- and diastereoselectivity.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, SDS of cas: 598-50-5.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Tingting published the artcileCobalt-Catalyzed Aerobic Oxidative Cleavage of Alkyl Aldehydes: Synthesis of Ketones, Esters, Amides, and α-Ketoamides, Product Details of C11H12O3, the main research area is alkyl aldehyde cobalt oxygen base oxidative cleavage catalyst; alc cobalt oxygen oxidation catalyst; ketone preparation; aldehyde amine secondary copper oxygen oxidative cleavage catalyst; ketoamide preparation; C−C bond cleavage; aerobic oxidation; cobalt; copper.

A widely applicable approach was developed to synthesize ketones, esters, amides via the oxidative C-C bond cleavage of readily available alkyl aldehydes. Green and abundant mol. oxygen (O2) was used as the oxidant, and base metals (cobalt and copper) were used as the catalysts. This strategy can be extended to the one-pot synthesis of ketones from primary alcs. and α-ketoamides from aldehydes.

Chemistry – A European Journal published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhu, Xiancui published the artcileSynthesis of rare-earth metal complexes with a morpholine-functionalized β-diketiminato ligand and their catalytic activities towards C-O and C-N bond formation, HPLC of Formula: 5961-59-1, the main research area is rare earth morpholine functionalized beta diketiminato complex preparation; crystal structure rare earth morpholine functionalized beta diketiminato complex; alcoholysis aminolysis catalyst rare earth morpholine beta diketiminato complex.

Unusual tridentate β-diketiminato rare-earth metal chlorides LRECl(μ-Cl)2Li(THF)2 (RE = Y (1a), Yb (1b), and Lu (1c); L = MeC(NDipp)CHC(Me)N(CH2)2NC4H8O; Dipp = 2,6-iPr2C6H3) and the corresponding dialkyl complexes LRE(CH2SiMe3)2 (RE = Y (2a), Yb (2b), and Lu (2c)) were prepared by reaction of a morpholine-functionalized β-diketiminato proligand HL with anhydrous RECl3 and rare-earth metal trialkyl complexes RE(CH2SiMe3)3(THF)2, resp. In 1 and 2, the morpholine moiety displayed a stable chair conformation and the resulting ligand coordinated to the rare-earth metal ion in a [NNN]-tridentate chelating fashion. Further these dialkyl complexes showed high activity towards the catalytic formation of C-O and C-N bonds in the alcoholysis of isothiocyanates and aminolysis of epoxides. A series of O-thiocarbamate derivatives were achieved in good to excellent yields by reaction of various alcs. with aromatic and aliphatic-substituted isothiocyanates at room temperature In addition, under solvent-free conditions, the ring-opening reaction of terminal and internal epoxides with arylamines yielded the corresponding β-amino alcs. with excellent regioselectivity. More importantly, a novel β-diketiminato/anilido yttrium alkyl complex LY(NHDipp)(CH2SiMe3) (5a) was isolated and characterized by the stoichiometric reaction of 2a with diisopropylaniline.

Dalton Transactions published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chalk, Alan J. published the artcilePalladium-catalyzed vinyl substitution reactions. II. Synthesis of aryl substituted allylic alcohols, aldehydes, and ketones from aryl halides and unsaturated alcohols, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is allylic alc aryl halide; ketone aralkyl; aldehyde aralkyl.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. A variety of substituted bromo- and iodobenzenes reacted with CH2:CMeCH2OH, CH2:CHCHMeOH, and CH2:CHCMe2OH in the presence of PdCl2 or Pd(OAc)2 and PPh3 to give, resp., Ph substituted derivatives of PhCH2 CHMeCHO, Ph(CH2)2COMe, and PhCH:CHCMe2OH. With some nonallylic unsaturated alcs., carbonyl compounds were formed via double bond migration. Formation of the intermediate aryl-substituted unsaturated alcs. was minimal unless a quaternary carbon separated the double bond from the alc. function.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ashok, D. published the artcileGreen synthesis of spiropyranone 3-aryl-4-methylcoumarin derivatives using carbonyldiimidazole, HPLC of Formula: 104-01-8, the main research area is spiropyranone aryl methylcoumarin preparation microwave irradiation green chem; monospirohydroxy acetophenone phenylacetic acid cyclization.

A series of spiropyranone 3-aryl-4-methylcoumarin derivatives I [R = H, Cl, OMe, Me; X = -(CH2)2-, -CH2N(C(O)OC(CH3)3)-, -CH2-] have been synthesized from monospiro-2-hydroxy acetophenones II in a novel and efficient green method using imidazolyl intermediates and inorganic base. Imidazolyl intermediates were in turn generated by grinding the resp. phenylacetic acid 4-RC6H4CH2C(O)OH along with carbonyldiimidazole (CDI). Similarly, monospiro-2-hydroxy acetophenone derivatives II were prepared selectively by avoiding formation of bis derivatives following literature procedure.

Asian Journal of Chemistry published new progress about Chromones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, HPLC of Formula: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem