Category: 1082041-78-8

1082041-78-8, 6-Methyl-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 71 Preparation of 6-methyl-2-(4-(trifluoromethyl)pyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (71A) 6-Methyl-3,4-dihydroisoquinolin-1(2H)-one (I-69d: 500 mg, 3.1 mmol) was reacted with 3-bromo-4-trifluoromethyl)-pyridine (842 mg, 3.72 mmol), 1,4-dioxane (20 mL), copper iodide (59 mg, 0.31 mmol), trans-N,N’-dimethyl-cyclohexyl-1,2-diamine (44 mg, 0.31 mmol and potassium phosphate (1.64 g, 7.76 mmol) 2 days at 120 C. to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCl3) afforded 150 mg of the product (15.7% yield)., 1082041-78-8

1082041-78-8 6-Methyl-3,4-dihydroisoquinolin-1(2H)-one 22890891, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra; US2014/45872; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1082041-78-8, 6-Methyl-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of Intermediate 6-methyl-2-(4-methylpyridin-3-yl)-3,4-dihydroisoquinolin-1(2H)-one (I-69e) 6-Methyl-3,4-dihydroisoquinolin-1(2H)-one (I-69f: 2 g, 12.422 mmol) was reacted with 3-iodo-4-methyl-pyridine (2.72 g, 12.422 mmol), 1,4-dioxane (70 mL), copper iodide (236 mg, 1.2422 mmol), trans-N,N’-dimethyl-cyclohexyl-1,2-diamine (530 mg, 3.727 mmol) and potassium phosphate (6.58 g, 31.055 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in DCM) afforded 1 g of the product (31.8% yield). LCMS: 98.66%, m/z=253.0 (M+1), 1082041-78-8

As the paragraph descriping shows that 1082041-78-8 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra; US2014/45872; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1082041-78-8,6-Methyl-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

6-MethyI-3 -dihydroisoquinoliB~l(2H)~one (I-69d: SOOmg, 3.1 mmol) was reacted with 3~bromo-4-(trifluoromethyl)^yrid:ine (842rng, 3.72mmol), 1 ,4-dioxane (20mL), copper iodide (S9mg, OJ lm oi), . r^m’-N^N’-dimethyl-cyclbhexyl- 1 ,2- diaraine (44mg, 0.31mmo ) and potassium phosphate (1 ,64g5 7.76inmoi) 2 days ai 120C to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCI3) afforded 150 mg of the product (15.7% yield),, 1082041-78-8

The synthetic route of 1082041-78-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra; WO2012/35078; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem