With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1082041-78-8,6-Methyl-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
6-MethyI-3 -dihydroisoquinoliB~l(2H)~one (I-69d: SOOmg, 3.1 mmol) was reacted with 3~bromo-4-(trifluoromethyl)^yrid:ine (842rng, 3.72mmol), 1 ,4-dioxane (20mL), copper iodide (S9mg, OJ lm oi), . r^m’-N^N’-dimethyl-cyclbhexyl- 1 ,2- diaraine (44mg, 0.31mmo ) and potassium phosphate (1 ,64g5 7.76inmoi) 2 days ai 120C to afford the crude product. Purification by column chromatography on silica gel (2% methanol in CHCI3) afforded 150 mg of the product (15.7% yield),, 1082041-78-8
The synthetic route of 1082041-78-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; BOCK, Mark G.; GAUL, Christoph; GUMMADI, Venkateshwar Rao; MOEBITZ, Henrik; SENGUPTA, Saumitra; WO2012/35078; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem