With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-05-9,6-Bromoisoquinoline,as a common compound, the synthetic route is as follows.
General procedure: 1,3-Dimethylbarbituric acid-based alkenes 1 (0.2 mmol), isoquinolines 2 (0.2 mmol) and methyl perfluoroalk-2-ynoates 3 (0.24 mmol) were stirred in MeCN (2.0 mL) at 50 C for 2 h. When methyl 4,4,4-trifluorobut-2-ynoate 3a was used as substrate, the solvent was removed under reduced pressure, DCM (1.0 mL) and silica gel (200 mesh, 0.5 g) were added. The mixture was stirred at room temperature for another 1 h. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel by eluting with petroleum ether / ethyl acetate (10:1) to afford the desired products 4; If methyl 4,4,5,5,5-pentafluoropent-2-ynoate 3b or methyl 4,4,5,5,6,6,6-heptafluorohex-2-ynoate 3c was served as starting material, the solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel by eluting with petroleum ether / ethyl acetate (10:1) to afford the desired products 4 and 4′.
34784-05-9, 34784-05-9 6-Bromoisoquinoline 313681, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Article; Yu, Minhui; Wu, Yueci; Peng, Xin; Han, Jing; Chen, Jie; Kan, Yuhe; Deng, Hongmei; Shao, Min; Zhang, Hui; Cao, Weiguo; Journal of Fluorine Chemistry; vol. 216; (2018); p. 33 – 42;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem