Category: 1109230-25-2

1109230-25-2, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[001081 A mixture of 5-bromo-3,4-dihydro-2H-isoquinolin-1-one (Preparation 3-1, 4.3 g, 18.9 mmol) and 2,3-dicyano-5,6-dichloro-1,4-benzoquinone (8.6 g, 37.9 mmol) in 1,4-dioxane (76 mL) was stirred at 100 C for 24 h. The reaction mixture was evaporated and the residue was taken up in ethyl acetate (500 mL) and washed with 10% aqueous sodium hydroxide (2 x 500 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (4 x 300 mL). The combined organic layers were dried over sodium sulfate, evaporated and purified by flash chromatography eluting with dichloromethane:methanol (99:1 -96:4) to give the title compound (1.49 g, 6.65 mmol, 35%) as a yellow solid. LCMS: 94%, Rt 1.243, ESMS m/z 224 (M+H)., 1109230-25-2

The synthetic route of 1109230-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOST’YU “PANACELA LABS”; GUROVA, Katerina; RYDKINA, Elena Borisovna; WADE, Warren; WO2015/50471; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1109230-25-2, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 0.15 g of 5-bromo-3,4-dihydroisoquinolin-1(2H)-one in 5 cm3 of dimethylformamide is poured into a mixture containing 31 mg of sodium hydride (60% in oil) and 10 cm3 of dimethylformamide at a temperature close to 20 C. under an inert atmosphere. Then a solution of 0.2 g of 1-(1-bromoethyl)-4-fluorobenzene in 5 cm3 of dimethylformamide is poured into the reaction mixture. The latter is stirred for 20 h at a temperature close to 20 C. Water and ethyl acetate are added to the reaction mixture. After decanting, the organic phase is washed with a saturated aqueous solution of sodium chloride, dried over magnesium sulfate, filtered then concentrated using a rotary evaporator under reduced pressure (5 kPa). The 325 mg of crude product obtained are purified by filtration through a silica pellet (eluent: 20% ethyl acetate/80% cyclohexane). After concentrating the fractions under reduced pressure, 146 mg of 5-bromo-2-[1-(4-fluorophenyl)ethyl]-3,4-dihydroisoquinolin-1(2H)-one are obtained in the form of a thick pale yellow oil.NMR: ppm: 1.54 (d, J=7.3 Hz, 3H) 2.85 (m, 1H) 2.97 (m, 1H) 3.10 (m, 1H) 3.47 (m, 1H) 5.92 (q, J=7.3 Hz, 1H) 7.18 (t, J=8.8 Hz, 2H) 7.33 (t, J=8.1 Hz, 1H) 7.41 (dd, J=8.8, 5.9 Hz, 2H) 7.78 (dd, J=8.1, 1.4 Hz, 1H) 7.98 (dd, J=8.1, 1.4 Hz, 1H)LC-MS-DAD-ELSD: [M+H]+ m/z=348, 1109230-25-2

1109230-25-2 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one 21865472, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; SANOFI-AVENTIS; US2010/197725; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem