Category: 117-96-4

Shafieyan, Yousef published the artcileDiffusion of MRI and CT Contrast Agents in Articular Cartilage under Static Compression, Name: Diatrizoic Acid, the main research area is diffusion MRI CT contrast agent articular cartilage static compression.

Cartilage has a limited capacity for self-repair and focal damage can eventually lead to complete degradation of the tissue. Early diagnosis of degenerative changes in cartilage is therefore essential. Contrast agent-based computed tomog. and magnetic resonance imaging provide promising tools for this purpose. However, the common assumption in clin. applications that contrast agents reach steady-state distributions within the tissue has been of questionable validity. Characterization of nonequilibrium diffusion of contrast agents rather than their equilibrium distributions may therefore be more effective for image-based cartilage assessment. Transport of contrast agent through the extracellular matrix of cartilage can be affected by tissue compression due to matrix structural and compositional changes including reduced pore size and fluid content. We therefore investigate the effects of static compression on diffusion of three common contrast agents: sodium iodide, sodium diatrizoate, and gadolinium diethylenetriamine-pentaacid (Gd-DTPA). Results showed that static compression was associated with significant decreases in diffusivities for sodium iodide and Gd-DTPA, with similar (but not significant) trends for sodium diatrizoate. Mol. mass of contrast agents affected diffusivities as the smallest one tested, sodium iodide, showed higher diffusivity than sodium diatrizoate and Gd-DTPA. Compression-associated cartilage matrix alterations such as glycosaminoglycan and fluid contents were found to correspond with variations in contrast agent diffusivities. Although decreased diffusivity was significantly correlated with increasing glycosaminoglycan content for sodium iodide and Gd-DTPA only, diffusivity significantly increased for all contrast agents by increasing fluid fraction. Because compounds based on iodine and gadolinium are commonly used for computed tomog. and magnetic resonance imaging, present findings can be valuable for more accurate image-based assessment of variations in cartilage composition associated with focal injuries.

Biophysical Journal published new progress about Articular cartilage. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Name: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Frost, Anna Buus published the artcileOn the search for in vitro in vivo correlations in the field of intra-articular drug delivery: Administration of sodium diatrizoate to the horse, Recommanded Product: Diatrizoic Acid, the main research area is intraarticular drug delivery joint synovial fluid sodium diatrizoate.

Development of suitable in vitro release models for formulation development as well as quality control purposes has to be initiated in the early design phase of injectable depots. Optimally, construction of an in vitro release model may lead to the establishment of in vitro in vivo correlations. By using a model compound (sodium diatrizoate, DTZ), the purpose of this study was to investigate the possibility of establishing in vitro in vivo relations between the DTZ disappearance profile obtained from the donor compartment of the rotating dialysis cell model and the joint disappearance profile following intra-articular administration. In vitro experiments were conducted by applying solutions of DTZ to the donor compartment. In the in vivo experiments, five horses were subjected to both i.v. and intra-articular administration of an aqueous solution of 3.9 mg DTZ/kg. A strong relation (R 2 = 0.99) was obtained between the disappearance data from the donor compartment of the in vitro model and the disappearance data from the synovial fluid after intra-articular administration of DTZ. Furthermore, a relation (R 2 = 0.91) between the appearance data obtained from the acceptor compartment and the deconvolved appearance serum data upon intra-articular administration of DTZ was obtained. The correlations obtained in this study hold promise that the rotating dialysis cell model has a role in the prediction of the intra-articular fate of drugs injected as solutions

European Journal of Pharmaceutical Sciences published new progress about Drug bioavailability. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Recommanded Product: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Watanabe, Ippei published the artcileEffect of contrast media on the enzyme activity of condoliase: In vitro assessment, Recommanded Product: Diatrizoic Acid, the main research area is Condoliase chondroitin sulfate amidotrizoic acid iohexol iotrolan; Morgan–Elson method; chondroitin sulfate; condoliase; contrast media; lumbar disc herniation.

Background : Condoliase has been used in Japan to treat patients with lumbar disk herniation by its injection into the nucleus pulposus. The injection of condoliase together with contrast media is prohibited; because there are no data whether contrast media have any effect on condoliase activity. This study aimed to elucidate the effects of contrast media on condoliase activity. Methods : Condoliase with chondroitin sulfate (CS) and without CS were mixed with various contrast media (nonionic [iohexol or iotrolan]; ionic [amidotrizoic acid]). (i) The mixtures with CS were incubated at 37°C; (ii) the mixtures without CS were stored at 24°C for 60 min, followed by addition of CS to assess condoliase activity by measuring the amount of N-acetylhexosamines enzymically cleaved from CS using Morgan-Elson method. Results : (i) In the presence of CS, the ionic contrast media reduced condoliase activity within 10 min in a dose-dependent manner, and the nonionic contrast media had no effect on condoliase activity for at least 120 min. (ii) In the absence of CS, the ionic contrast media almost completely inactivated condoliase within 15 min, and the nonionic contrast media also reduced condoliase activity; the residual activity was 65% with iotrolan and 35% with iohexol at 60 min. Conclusions : The ionic contrast media significantly reduced condoliase activity regardless of presence or absence of CS. Although the nonionic contrast media did not affect condoliase activity in the presence of CS, it reduced activity in the absence of CS. Mixing condoliase with contrast media, especially ionic type contrast media, should be avoided.

JOR Spine published new progress about Hernia (lumbar disk). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Recommanded Product: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Xianbing published the artcileEffect of metal ions on oxidation of micropollutants by ferrate(VI): Enhancing role of FeIV species, Formula: C11H9I3N2O4, the main research area is effect metal ion oxidation micropollutants ferrate enhancing role.

This paper investigated the oxidation of recalcitrant micropollutants [i.e., atenolol (ATL), flumequine, aspartame, and diatrizoic acid] by combining ferrate(VI) (FeVIO42-, FeVI) with a series of metal ions [i.e., Fe(III), Ca(II), Al(III), Sc(III), Co(II), and Ni(II)]. An addition of Fe(III) to FeVI enhanced the oxidation of micropollutants compared solely to FeVI. The enhanced oxidation of studied micropollutants increased with increasing [Fe(III)]/[FeVI] to 2.0. The complete conversion of Ph Me sulfoxide (PMSO), as a probe agent, to Ph Me sulfone (PMSO2) by the FeVI-Fe(III) system suggested that the highly reactive intermediate FeIV/FeV species causes the increased oxidation of all four micropollutants. A kinetic modeling of the oxidation of ATL demonstrated that the major species causing the increase in ATL removal was FeIV, which had an estimated rate constant as (6.3 ± 0.2) x 104 M-1 s-1, much higher than that of FeVI [(5.0 ± 0.4) x 10-1 M-1 s-1]. Mechanisms of the formed oxidation products of ATL by FeIV, which included aromatic and/or benzylic oxidation, are delineated. The presence of natural organic matter significantly inhibited the removal of four pollutants by the FeVI-Fe(III) system. The enhanced effect of the FeVI-Fe(III) system was also seen in the oxidation of the micropollutants in river water and lake water.

Environmental Science & Technology published new progress about Lake water pollution. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Formula: C11H9I3N2O4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Scheurer, Marco published the artcileCorrelation of six anthropogenic markers in wastewater, surface water, bank filtrate, and soil aquifer treatment, Category: isoquinoline, the main research area is wastewater surface bank filtrate soil aquifer treatment anthropogenic marker.

Six trace contaminants (acesulfame (ACE), sucralose (SUC), carbamazepine (CBZ), diatrizoic acid (DTA), 1H-benzotriazole (BTZ) and its 4-Me analog (4-TTri)) were traced from wastewater treatment plants (WWTPs) to receiving waters and further to riverbank filtration (RBF) wells to evaluate their prediction power as potential wastewater markers. Furthermore, the persistence of some compounds was investigated in advanced wastewater treatment by soil aquifer treatment (SAT). During wastewater treatment in four conventional activated sludge WWTPs ACE, SUC, and CBZ showed a pronounced stability expressed by stable concentration ratios in influent (in) and effluent (out) (ACE/CBZ: In45, out40; SUC/CBZ: In1.8, out1.7; and ACE/SUC: In24, out24). In a fifth WWTP, addnl. treatment with powd. activated carbon led to a strong elimination of CBZ, BTZ, and 4-TTri of about 80% and consequently to a distinctive shift of their ratios with unaffected compounds Data from a seven month monitoring program at seven sampling locations at the rivers Rhine and Main in Germany revealed the best concentration correlation for ACE and CBZ (r2 = 0.94) and also a good correlation of ACE and CBZ concentrations to BTZ and 4-TTri levels (r2 = 0.66 to 0.82). The comparison of ratios at different sampling sites allowed for the identification of a CBZ point source. Furthermore, in Switzerland a higher consumption of SUC compared to Germany can be assumed, as a steadily increasing ACE/SUC ratio along the river Rhine was observed In RBF wells a good correlation (r2 = 0.85) was again observed for ACE and CBZ. Both also showed the highest stability at a prolonged residence time in the subsurface of a SAT field. In the most peripheral wells ACE and CBZ were still detected with mean values higher than 36 μg L-1 and 1.3 μg L-1, resp. Although SUC concentrations in wastewater used for SAT decreased by more than 80% from about 18 μg L-1 to 2.1 μg L-1 and 3.5 μg L-1 in these outlying wells, the compound was still adequate to indicate a wastewater impact in a qual. way.

Journal of Environmental Monitoring published new progress about Municipal wastewater. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cinteza, Eliza published the artcileIodinated contrast media in pediatric cardiac angiography nephrotoxic risk evaluation, Synthetic Route of 117-96-4, the main research area is iodinated contrast agent cardiac angiog nephrotoxicity nephropathy AKI.

Contrast agents are among the most frequently used drugs in medical practice. The aim of our study was to evaluate the incidence of complications associated with the use of different contrast agents in an angiog. lab dedicated to pediatric patients with congenital heart disease. Between June 2015 and Dec. 2017, 166 patients with congenital heart disease were diagnosed and/or treated in the angiog. laboratory Of these patients, 38 were excluded because they did not require contrast substance administration. As interventional procedures we performed pulmonary valvular dilatation in 17 cases (10.2%), stent implantation in coarctation of the aorta in 9 cases (5.4%), PDA closure in 62 cases (37.3%), atrial septal defect (ASD) closure in 36 patients (including patients without contrast agent’s administration) (21.7%). In the group of 129 patients who received contrast agents, the median age was 5.8 years (range 0.1-19 years) and median weight 22.8 kg (range 2.8-72 kg). Average consumption of contrast media per procedure was 79 mL/procedure (range 5 – 400 mL) and 4.3 mL/kg (range 0.4 – 22.7). We used iomeprol (24%), iohexol (8.5%), iopromide (67.4%). No contrast related complications are reported in this group. In conclusion, the contrast agents we used seem to be safe and are not associated with renal complications.

Revista de Chimie (Bucharest, Romania) published new progress about Acute kidney injury. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Synthetic Route of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Yixuan published the artcileInhibition effect of Zedoary turmeric oil on Listeria monocytogenes and Staphylococcus aureus growth and exotoxin proteins production, Computed Properties of 117-96-4, the main research area is Listeria Staphylococcus zedoary turmeric oil exotoxin protein inhibition effect; Listeria monocytogenes; Staphylococcus aureus; Zedoary turmeric oil; essential oil composition; virulence factors.

Purpose. Zedoary turmeric oil (ZTO), the steam extract of Curcuma zedoaria Rosc was researched for its chem. composition, antibacterial activity, and mechanism for countering two major food-borne pathogenic species, Listeria monocytogenes and Staphylococcus aureus. Methodol. Gas chromatog.-mass spectrometry (GC-MS) was used to analyze and characterize the chem. composition of ZTO. Its MICs for the two bacterial species and growth curves were measured. Western blot and real-time reverse-transcription (RT)-PCR assays were utilized to elaborate the mechanism of the antibacterial effect of ZTO by examining the expression levels of virulence-related extracellular proteins. ELISA was used to explore the biol. relevance. Results. GC-MS revealed high contents of curzerene, eucalyptol, germacrone and (-)-g-elemene representing 28.45, 10.94, 10.77 and 10.54%, resp., of the whole components. The MICs of ZTO that combated L. monocytogenes and S. aureus were similar (1-2 mg ml-1 ). After adding ZTO at increasing concentrations, there was an evident reduction in the transcription of hly, iap, hla, sea, seb and agrA in a dose-dependent manner. Furthermore, TNF-α accumulation in RAW264.7 cells stimulated by L. monocytogenes and S. aureus supernatants was restricted by a 1/4 MIC of ZTO. Conclusion. Overall, L. monocytogenes and S. aureus were comparably susceptible to ZTO. These data demonstrated that ZTO’s antimicrobial property was mediated by the repression of the production of virulence factors involved in L. monocytogenes and S. aureus pathogenesis, a finding that can potentially further progress in the development of new anti-virulence drugs.

Journal of Medical Microbiology published new progress about Antibacterial agents. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Computed Properties of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hennebel, Tom published the artcilePalladium nanoparticles produced by fermentatively cultivated bacteria as catalyst for diatrizoate removal with biogenic hydrogen, Application In Synthesis of 117-96-4, the main research area is bacterial palladium nanoparticle diatrizoate removal.

A new biol. inspired method to produce nanopalladium is the precipitation of Pd on a bacterium, i.e., bio-Pd. This bio-Pd can be applied as catalyst in dehalogenation reactions. However, large amounts of hydrogen are required as electron donor in these reactions resulting in considerable costs. This study demonstrates how bacteria, cultivated under fermentative conditions, can be used to reductively precipitate bio-Pd catalysts and generate the electron donor hydrogen. In this way, one could avoid the costs coupled to hydrogen supply. The catalytic activities of Pd(0) nanoparticles produced by different strains of bacteria (bio-Pd) cultivated under fermentative conditions were compared in terms of their ability to dehalogenate the recalcitrant aqueous pollutants diatrizoate and trichloroethylene. While all of the fermentative bio-Pd preparations followed first order kinetics in the dehalogenation of diatrizoate, the catalytic activity differed systematically according to hydrogen production and starting Pd(II) concentration in solution Batch reactors with nanoparticles formed by Citrobacter braakii showed the highest diatrizoate dehalogenation activity with first order constants of 0.45 ± 0.02 h-1 and 5.58 ± 0.6 h-1 in batches with initial concentrations of 10 and 50 mg L-1 Pd, resp. Nanoparticles on C. braakii, used in a membrane bioreactor treating influent containing 20 mg L-1 diatrizoate, were capable of dehalogenating 22 mg diatrizoate mg-1 Pd over a period of 19 days before bio-Pd catalytic activity was exhausted. This study demonstrates the possibility to use the combination of Pd(II), a carbon source and bacteria under fermentative conditions for the abatement of environmental halogenated contaminants.

Applied Microbiology and Biotechnology published new progress about Bacteroides vulgatus. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Application In Synthesis of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Liang published the artcileEnhanced removal of pharmaceuticals in a biofilter: Effects of manipulating co-degradation by carbon feeding, Name: Diatrizoic Acid, the main research area is carbon feeding degradation pharmaceutical removal biofilter; Biodegradation; Biofiltration; Co-metabolism; Micropollutants; Sand filter.

Biofilm reactors are a promising biotechnol. to eliminate pharmaceuticals from wastewater during tertiary treatment or in water works for drinking water production This study aimed at investigating the effects of pulsed carbon feeding for promoting the co-degradation of indigenous pharmaceuticals from pre-treated wastewater in a fixed-bed porous biofilm reactor (slow sand filter). The addition of acetate (carbon source) resulted in three different enhancement/limitation effects, which were compound dependent: 1. atenolol and iohexol experienced enhanced co-degradation followed by constant (acetate independent) degradation; 2. metoprolol, iomeprol, diclofenac, propranolol and sulfamethizole co-degradation dependent on aerobic turnover, but inhibited at higher acetate concentrations (60-300 mg C/L); 3. sulfadiazine, sulfamethoxazole and trimethoprim were removed independently of oxygen and acetate concentration Carbamazepine, ditriazoic acid, iopromide; tramadol and venlavaxine were not removed at any acetate dosage. Biofilm reactors can be employed for polishing treated wastewater, and the addition of a primary carbon source can enhance the performance of the bioreactor.

Chemosphere published new progress about Biofilms (microbial). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Name: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tang, Kai published the artcileRemoval of pharmaceuticals in conventionally treated wastewater by a polishing moving bed biofilm reactor (MBBR) with intermittent feeding, Quality Control of 117-96-4, the main research area is activated sludge biofilm biol pharmaceutical wastewater treatment; Degradation; Diclofenac; End-of-pipe; Pharmaceuticals; Suspended biofilm.

Previous studies have demonstrated that aerobic moving bed biofilm reactors (MBBRs) remove pharmaceuticals better than activated sludge. Thus we used a MBBR system to polish the effluent of an activated sludge wastewater treatment plant. To overcome that effluent contains insufficient organic matter to sustain enough biomass, the biofilm was intermittently fed with raw wastewater.The capacity of pharmaceutical degradation was investigated by spiking pharmaceuticals. Actual removal during treatment was assessed by sampling the inlets and outlets of reactors. The removal of the majority of pharmaceuticals was enhanced through the intermittent feeding of the MBBR. First-order rate constants for pharmaceutical removal, normalized to biomass, were significantly higher compared to other studies on activated sludge and suspended biofilms, especially for diclofenac, metoprolol and atenolol. Due to the intermittently feeding, degradation of diclofenac occurred with a half-life of only 2.1 h and was thus much faster than any hitherto described wastewater bioreactor treatment.

Bioresource Technology published new progress about Biofilms (microbial). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Quality Control of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem