Category: 27104-73-0

Yamazaki, Kazuo et al. published their research in Journal of the Chemical Society, Perkin Transactions 1 in 2002 | CAS: 27104-73-0

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Product Details of 27104-73-0

Palladium-catalyzed tandem C,N-arylation of immobilized enamine for solid phase indole synthesis was written by Yamazaki, Kazuo;Nakamura, Yosuke;Kondo, Yoshinori. And the article was included in Journal of the Chemical Society, Perkin Transactions 1 in 2002.Product Details of 27104-73-0 This article mentions the following:

Intramol. palladium-catalyzed N-arylation of immobilized dehydrohalophenylalaninate was found to proceed smoothly to form indolecarboxylates. The method was successfully combined with the Heck reaction to perform one pot indole synthesis via palladium-catalyzed tandem C,N-arylation reactions. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Product Details of 27104-73-0).

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Product Details of 27104-73-0

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Cao, Zhu et al. published their research in Green Chemistry | CAS: 27104-73-0

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Related Products of 27104-73-0

Metal-free photo-induced heteroarylations of C-H and C-C bonds of alcohols by flow chemistry was written by Cao, Zhu;Ji, Meishan;Wang, Xinxin;Wu, Xinxin;Li, Yahong;Zhu, Chen. And the article was included in Green Chemistry.Related Products of 27104-73-0 This article mentions the following:

Practical, metal-free heteroarylations of C-H and C-C bonds of unprotected aliphatic alcs. ROH (R = 5-hydroxypentan-2-yl, 6-hydroxyhexan-3-yl, 5-hydroxy-2-methylpentan-2-yl, etc.) are accomplished in a ′stop-flow′ micro-tubing reactor. The reactions proceed through alkoxy radical-triggered hydrogen atom transfer and β-C(sp3)-C(sp3) bond rupture under mild photochem. conditions, leading to a plethora of valuable functionalized heteroarenes ArR (Ar = 4-chloroquinolin-2-yl, 4-methylquinolin-2-yl, quinazolin-4-yl, etc.). The reaction is amenable for late-stage functionalization of complex heteroarenes, and can be readily scaled up by a continuous-flow method. The protocol features many advantages including good regioselectivity, broad functional group compatibility, and easy operation, and may find potential use in medicinal chem. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Related Products of 27104-73-0).

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Related Products of 27104-73-0

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Cho, Yun Jin et al. published their research in Analytical Science & Technology in 1998 | CAS: 27104-73-0

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Formula: C11H9NO2

Separation of functionalized heterocyclic compounds by high performance liquid chromatography (II) was written by Cho, Yun Jin;Lee, Young Cheol;Lee, Kwang-Pill;Park, Keung-Shik. And the article was included in Analytical Science & Technology in 1998.Formula: C11H9NO2 This article mentions the following:

Normal phase or reversed phase liquid chromatog. separation of isoquinoline of heterocyclic compounds and structural isomers of external substituents, COOCH3, CN and CH3 was carried out by using several different columns and various mobile phases. The order of elution of heterocyclic compounds appears to depend on the solvent effect with kinds of mobile phases. Retention mechanism of normal phase system for 2-methylindoline, 2-methylindole, benzoxazole and benzothiazole was also studied depending on adsorption strength between solute and stationary phase of column. However, retention factors of reversed phase system were found on hydrophobic interaction with solvophobic effect. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Formula: C11H9NO2).

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Formula: C11H9NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

Brief introduction of 27104-73-0

27104-73-0, 27104-73-0 Methyl isoquinoline-3-carboxylate 725374, aisoquinoline compound, is more and more widely used in various fields.

27104-73-0, Methyl isoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a cooled solution 0C of isoquinoline-3-carboxylic acid methyl ester (l. Og, 5.34mmol) in anhydrous tetrahydrofuran (100ml), is added a solution of DIBAL-H (11. 8ml, 11. 8mmol). The reaction mixture is stirred at 0C for 2 hours and then quenched with saturated aqueous sodium potassium tartrate and stirred for 2 hours. The layers are separated and the aqueous layer is extracted with ethyl acetate. The combined organic extracts are washed with 1N HCl, 2N NaOH, and dried over anhydrous Na2S04, filtered, and concentrated ira vacuo. The crude reaction mixture is purified on silica gel eluting with 20% ethyl acetate/hexanes to give isoquinoline-3-carboxaldehyde (0.46g, 54%).’H NMR (CDC13) : 8 = 10.24 (1H, brs), 9.32 (1H, brs), 8.35 (1H, brs), 8. 02 (2H, brd), 7.77 (2H, brs).

27104-73-0, 27104-73-0 Methyl isoquinoline-3-carboxylate 725374, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2005/92885; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Some tips on 27104-73-0

27104-73-0, As the paragraph descriping shows that 27104-73-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27104-73-0,Methyl isoquinoline-3-carboxylate,as a common compound, the synthetic route is as follows.

Example 11;: 3-Amino-6- [4- (2-hydroxy-2-isoquinolin-3-yl-ethylamino)-piperidin-1-yl]- 4-propyl-thieno [2, 3-b] pyridine-2-carboxylic acid amide Methyl 3-isoquinoline carboxylate (1.50 g, 8.01 mmol) was placed in 60 mL anhydrous toluene and cooled to 0 C. The solution was treated dropwise with 1M DIBAL solution in toluene (8.2 mL, 8.2 mmol). The solution gradually changed from colorless to yellow and then orange during addition. After 2 h another 2 mL 1M DIBAL solution in toluene was added and the mixture was left stirring another 1 h at 0-10 C. The mixture was then quenched with aqueous Na K tartrate solution, stirred 15 min then diluted with brine and EtOAc. The layers were separated and the aqueous was extracted twice with EtOAc. The combined organics were washed with brine repeatedly (emulsion), dried (MgS04), filtered and the solvent was removed in vacuo. An orange oil was thus obtained, which was purified by flash column chromatography on Si02 using CH2Cl2/MeOH eluent mixtures. The desired isoquinoline carboxaldehyde was isolated as a yellow solid, 420 mg (33% of theory).

27104-73-0, As the paragraph descriping shows that 27104-73-0 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.; WO2005/56562; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Downstream synthetic route of 27104-73-0

The synthetic route of 27104-73-0 has been constantly updated, and we look forward to future research findings.

27104-73-0, Methyl isoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 71A Methyl 5-nitroisoquinoline-3-carboxylate Methyl isoquinoline-3-carboxylate (9.58 g, 51.2 mmol) in concentrated H2SO4 (100 mL) at 0 C. was treated with sodium nitrate (4.79 g, 56.4 mmol) in small portions such that the temperature was maintained below 5 C. Ten minutes after addition was complete, the reaction mixture was allowed to warm to room temperature and stirred for 2 hours. The mixture was poured over ice and adjusted to pH between 7 and 8 and filtered to afford the title compound as a bright yellow solid (11.44 g, 96%). MS (ESI+) m/z 233 (M+H)+; 1H NMR (DMSO, 300 MHz) delta 3.97 (s, 3H), 8.06 (t, J 8.2, 1H), 8.72 (dt, J 1.0, 8.2, 1H), 8.78 (dd, J 1.0, 7.8, 1H), 9.11 (s, 1H), 9.65 (s, 1H).

The synthetic route of 27104-73-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Lee, Chih-Hung; Bayburt, Erol K.; DiDomenico, Stanley; Drizin, Irene; Gomtsyan, Arthur R.; Koenig, John R.; Perner, Richard J.; Schmidt, Robert G.; Turner, Sean C.; Jinkerson, Tammie K.; Zheng, Guo Zhu; US2005/113576; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem