Metal-free photo-induced heteroarylations of C-H and C-C bonds of alcohols by flow chemistry was written by Cao, Zhu;Ji, Meishan;Wang, Xinxin;Wu, Xinxin;Li, Yahong;Zhu, Chen. And the article was included in Green Chemistry.Related Products of 27104-73-0 This article mentions the following:
Practical, metal-free heteroarylations of C-H and C-C bonds of unprotected aliphatic alcs. ROH (R = 5-hydroxypentan-2-yl, 6-hydroxyhexan-3-yl, 5-hydroxy-2-methylpentan-2-yl, etc.) are accomplished in a ′stop-flow′ micro-tubing reactor. The reactions proceed through alkoxy radical-triggered hydrogen atom transfer and β-C(sp3)-C(sp3) bond rupture under mild photochem. conditions, leading to a plethora of valuable functionalized heteroarenes ArR (Ar = 4-chloroquinolin-2-yl, 4-methylquinolin-2-yl, quinazolin-4-yl, etc.). The reaction is amenable for late-stage functionalization of complex heteroarenes, and can be readily scaled up by a continuous-flow method. The protocol features many advantages including good regioselectivity, broad functional group compatibility, and easy operation, and may find potential use in medicinal chem. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Related Products of 27104-73-0).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Related Products of 27104-73-0
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem