Separation of functionalized heterocyclic compounds by high performance liquid chromatography (II) was written by Cho, Yun Jin;Lee, Young Cheol;Lee, Kwang-Pill;Park, Keung-Shik. And the article was included in Analytical Science & Technology in 1998.Formula: C11H9NO2 This article mentions the following:
Normal phase or reversed phase liquid chromatog. separation of isoquinoline of heterocyclic compounds and structural isomers of external substituents, COOCH3, CN and CH3 was carried out by using several different columns and various mobile phases. The order of elution of heterocyclic compounds appears to depend on the solvent effect with kinds of mobile phases. Retention mechanism of normal phase system for 2-methylindoline, 2-methylindole, benzoxazole and benzothiazole was also studied depending on adsorption strength between solute and stationary phase of column. However, retention factors of reversed phase system were found on hydrophobic interaction with solvophobic effect. In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Formula: C11H9NO2).
Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Formula: C11H9NO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem