Srivastava, Sanjay K. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 1996 | CAS: 63927-23-1

5-Bromo-8-nitroisoquinoline (cas: 63927-23-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.COA of Formula: C9H5BrN2O2

Synthesis and antifilarial profile of 5-amino and 5,8-diamino isoquinoline derivatives: a new class of antifilarial agents was written by Srivastava, Sanjay K.;Chauhan, P. M. S.;Agarwal, S. K.;Bhaduri, A. P.;Singh, S. N.;Fatma, Nigar;Chatterjee, R. K.;Bose, Chhanda;Srivastava, V. M. L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1996.COA of Formula: C9H5BrN2O2 This article mentions the following:

The syntheses of 5-amino and 5,8-diamino isoquinoline derivatives, their antifilarial activity and their effect on metabolic activities of filaricidal are delineated. Some of the screened compounds have shown promising filaricidal response against Acanthocheilonema viteae in rodents. In the experiment, the researchers used many compounds, for example, 5-Bromo-8-nitroisoquinoline (cas: 63927-23-1COA of Formula: C9H5BrN2O2).

5-Bromo-8-nitroisoquinoline (cas: 63927-23-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.COA of Formula: C9H5BrN2O2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem