Category: 34784-02-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-02-6,3-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

Typical procedure for the palladium-catalyzed domino reaction of the 1,6-diynes with bromo(iso)quinoline: diyne 1a-p (1.0 equiv), 3-bromoquinoline (1.2 equiv), Pd(OAc)2 (2 mol %), and PPh3 (4 mol %) were added to the degassed solution of (n-Bu)3N (1.2 equiv) in DMF (5 mL) and the mixture was stirred at room temperature for 40 min then heated at 125-130 C for 24 h. The reaction mixture was cooled, quenched with water, and extracted with EtOAc (3¡Á5 mL). The combined organic layers were washed with hydrochloric acid (5%), aqueous sodium carbonate (5%), and saturated aqueous sodium chloride solution. After separation, the organic layer was dried over anhydrous MgSO4 and concentrated under reduced pressure. The residue was purified by flash chromatography (6:1 petroleum ether/EtOAc) to give the corresponding product 3.

34784-02-6, The synthetic route of 34784-02-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hu, Yimin; Zhu, Tao; Mu, Xiaolong; Zhao, Quansheng; Yu, Tao; Wen, Lei; Zhang, Yulong; Wu, Min; Zhang, Hao; Tetrahedron; vol. 68; 1; (2012); p. 311 – 318;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-02-6,3-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

Example 5 – Preparation of Precursor 282 Precursor 271 Precursor 282 To a dry, nitrogen-flushed flask was charged with Precursor 271 (0.20 g, 0.37 mmol), potassium teri-butoxide (0.05 g, 0.44 mmol), Pd(dba)2 (0.03 g, 0.03 mmol), DPE-phos (0.04 g, 0.07 mmol), 3-bromoisoquinoline (0.08 g, 0.86 mmol), and anhydrous toluene. The mixture was refluxed for 24 h. After cooling to room temperature, ethyl acetate was added, and the mixture was stirred for five minutes. The crude mixture was extracted with ethyl acetate and purified by chromatography on silica gel with mixture of hexane and ethyl acetate (v/v = 10: 1). 0.17 g of yellow solid was obtained. Yield: 69 %. H NMR (CDC13, 300 MHz): delta 9.03 (s, 1H), 8.00 (s, 1H), 7.83-7.96 (m, 4H), 7.69 (s, 1H), 7.53-7.45 (m, 6H), 7.39-7.30 (m, 5H), 7.25-7.23 (m, 2H), 7.15-7.02 (m, 4H), 3.85 (s, 3H), 1.37 (s, 18H)., 34784-02-6

The synthetic route of 34784-02-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE UNIVERSITY OF HONG KONG; CHE, ChiMing; KUI, ChiFai; KWOK, Chi Chung; WO2013/152727; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

34784-02-6, 3-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 12 – Preparation of Precursor 284 Precursor 273 Precursor 284 To a dry, nitrogen-flushed flask was charged with Precursor 273 (0.21 g, 0.44 mmol), potassium teri-butoxide (0.06 g, 0.52 mmol), Pd(dba)2 (0.04 g, 0.04 mmol), DPE-phos (0.05 g, 0.08 mmol), 3-bromoisoquinoline (0.09 g, 0.44 mmol), and anhydrous toluene. The mixture was refluxed for 24 h. After cooling to room temperature, ethyl acetate was added, and the mixture was stirred for five minutes. The crude mixture was extracted with ethyl acetate and purified by chromatography on silica gel with mixture of hexane and ethyl acetate (v/v = 10: 1). 0.17 g of yellow solid was obtained. Yield: 65 %. H NMR (CDC13, 400 MHz): delta 9.03 (s, 1H), 8.05 (s,lH), 7.95 (d, J = 7.6 Hz, 1H), 7.84 (d, J = 8.1 Hz, 1H), 7.60-7.50 (m, 5H), 7.46 (t, J = 7.9 Hz, 1H), 7.37-7.31 (m, 5H), 7.25-7.23 (m, 2H), 7.12 (s, 1H), 6.96 (d, J = 7.4 Hz, 1H), 6.84 (d, J = 8.1 Hz, 1H), 3.84 (s, 3H), 1.97-1.92 (m, 4H), 1.06-1.01 (m, 4H), 0.64-0.57 (m, 10H).

34784-02-6, As the paragraph descriping shows that 34784-02-6 is playing an increasingly important role.

Reference£º
Patent; THE UNIVERSITY OF HONG KONG; CHE, ChiMing; KUI, ChiFai; KWOK, Chi Chung; WO2013/152727; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-02-6,3-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

20mmol S15-1, 30.0mmol S15-2, 0.20mmol palladium(II)acetate catalyst and 36mmol trihydrate Potassium phosphate, dissolved in 30mL toluene: ethanol: water in a mixed solvent of water (2:1:2), it was heated at 70 C for 12 h. It was cooled and extracted with dichloromethane (50 mL¡Á3) three times. The organic phase was collected and purified by silica gel column chromatography eluting with petroleum ether:dichloromethane (10:1) to give solid S15-3 8.9 mmol (yield: 44.7%), 34784-02-6

As the paragraph descriping shows that 34784-02-6 is playing an increasingly important role.

Reference£º
Patent; Ruisheng Science And Technology (Singapore) Co., Ltd.; Cao Chenhui; Huang Da; (54 pag.)CN108191916; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-02-6,3-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

General procedure: A suspension of intermediate 15(104.0 mg, 0.4 mmol), 7-bromoquinoline (124.8 mg, 0.6 mmol), t-BuONa (96.0 mg, 1.0 mmol), Pd2(dba)3 (18.0 mg, 0.019 mmol) andX-phos (9.6 mg, 0.02 mmol) in PhMe (2.8 ml) was degassed under astream of nitrogen over 10 min. The mixture was heated to 110 Cand stirred overnight. The resulting mixturewas filtered off and thesolution was concentrated under vacuum. The crude product waspurified by column chromatography on silica using a solvent of 60%ethyl acetate in hexanes. Compound 3l was obtained as a lightgreen solid (Yield: 60.0 mg, 38.8%).

34784-02-6, The synthetic route of 34784-02-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yu, Jiang; Zhou, Peiting; Hu, Mingxing; Yang, Liuqing; Yan, Guoyi; Xu, Ruixue; Deng, Yufang; Li, Xinghai; Chen, Yuanwei; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem