34784-02-6, 3-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A suspension of 6-(l-cyclobutylpiperidin-4-yloxy)-3,4-dihydroquinolin-2(lH)-one synthesized in Example 4-(l) (0.10 g), 3-bromoisoquinoline (0.10 g), rac-trans-N,N’- dimethylcyclohexane-l,2-diamine (0.047 g), copper iodide (0.016 g) and cesium carbonate (0.22 g) in toluene (1 mL) was stirred at 1100C for 3 hours. The reaction mixture was cooled to room temperature, diluted with chloroform and filtered to remove insoluble materials. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by NH-type silica gel column chromatography (eluting solvent: hexane/ethyl acetate = 4/1 to 1/4) and OH-type preparative TLC (on two plates of 1 mm thickness, developing solvent: chloroform/methanol = 4/1) to give the titled compound (0.061 g, 44%) as a colorless amorphous substance.1H NMR (600 MHz, CHLOROFORM-d) delta ppm 1.54-2.24 (m, 12 H), 2.54-2.80 (m, 3 H), 2.82-2.91 (m, 2 H), 3.04-3.12 (m, 2 H), 4.17-4.31 (m, 1 H), 6.30 (d, J=8.7 Hz, 1 H), 6.57 (dd, J=8.7, 2.8 Hz, 1 H), 6.83 (d, J=2.8 Hz, 1 H), 7.56-7.64 (m, 1 H), 7.74-7.81 (m, 1 H), 7.84 (d, J=8.3 Hz, 1 H), 8.10-8.22 (m, 2 H), 8.74 (d, J=2.3 Hz, 1 H)MS (ESVAPCI Dual) (Positive) m/z; 428(M+H)+
As the paragraph descriping shows that 34784-02-6 is playing an increasingly important role.
Reference£º
Patent; TAISHO PHARMACEUTICAL CO., LTD.; NAKAMURA, Toshio; MASUDA, Seiji; FUJINO, Aya; WO2010/90347; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem