Category: 34784-07-1

34784-07-1, 8-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: 8-chloro-5-nitroisoquinolineTo a solution of 8-chloroisoquinoline (1 mmol) in concentrated sulfuric acid at 0 0C was added potassium nitrate (1.1 mmol) .The reaction mixture was warmed to room temperature and stirred at room temperature for 5 hours. The reaction mixture was basified .Solid precipitated was column purified to afford a pale yellow solid.1H NMR (DMSO- d6): delta /77.76 – 7.79 ( IH, d , J = 8.4 Hz ); 8.48 – 8.51 ( IH, d , J = 8.4 Hz ); 8.53 – 8.55 ( IH, d , J = 6 Hz ); 8.86 – 8.88 ( IH, d , J = 6.3 Hz ); 9.84 ( IH , s )

34784-07-1, As the paragraph descriping shows that 34784-07-1 is playing an increasingly important role.

Reference£º
Patent; GLENMARK PHARMACEUTICALS S.A.; WO2007/42906; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-07-1,8-Chloroisoquinoline,as a common compound, the synthetic route is as follows.

20a) 1, 8-DICHLORO-ISOQUINOLINE To a solution of 8-chloro-isoquinoline (J. Org. Chem. 1977,42 (19), 3208-9.) (11 G, 54 MMOL) in CH2CI2 (200 mL) is added MCPBA (25 g, 112 MMOL) in several portions. After stirring for 3 hours, ether (400 mL) is added, followed by addition of hexanes (1 L). Solution stirred overnight and conc in vacuo, ether (200 mL) and hexanes (400 mL) is added, stirred overnight. The ppt is filtered, air dried and mixed with 20 g of POS and toluene (150 mL). The solution is heated to reflux for 3 h, neutralized with NAHCO3. Extracted the solution with CH2CI2. Organic layer then dried with sodium sulfate and conc in vacuo, yield 8 g (72%) of 1, 8-Dichloro-isoquinoline. MS: 198

34784-07-1, The synthetic route of 34784-07-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/28444; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem