With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-07-1,8-Chloroisoquinoline,as a common compound, the synthetic route is as follows.
20a) 1, 8-DICHLORO-ISOQUINOLINE To a solution of 8-chloro-isoquinoline (J. Org. Chem. 1977,42 (19), 3208-9.) (11 G, 54 MMOL) in CH2CI2 (200 mL) is added MCPBA (25 g, 112 MMOL) in several portions. After stirring for 3 hours, ether (400 mL) is added, followed by addition of hexanes (1 L). Solution stirred overnight and conc in vacuo, ether (200 mL) and hexanes (400 mL) is added, stirred overnight. The ppt is filtered, air dried and mixed with 20 g of POS and toluene (150 mL). The solution is heated to reflux for 3 h, neutralized with NAHCO3. Extracted the solution with CH2CI2. Organic layer then dried with sodium sulfate and conc in vacuo, yield 8 g (72%) of 1, 8-Dichloro-isoquinoline. MS: 198
34784-07-1, The synthetic route of 34784-07-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2005/28444; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem