Category: 423146-25-2

Reference of 423146-25-2, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.423146-25-2, Name is 6-(6-Morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid, molecular formula is C22H24N2O5. In a Article，once mentioned of 423146-25-2

We present two ways of fast and easy immobilisation of a naphthalimide chromophore with a pH-sensor function. The immobilised dyes exhibit absorbance and emission in the visible spectral range, large Stokes’ shift, fluorescence properties that are comparable to their water-soluble form, and full reversibility in pH response

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Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

 

423146-25-2, Name is 6-(6-Morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid, belongs to isoquinoline compound, is a common compound. Product Details of 423146-25-2In an article, once mentioned the new application about 423146-25-2.

Highly fluorescent and HDAC6 selective scriptaid analogues

Fluorescent scriptaid analogues with excellent HDAC6 selectivity (HDAC1/6 > 500) and potency (HDAC6 IC50 < 5 nM) have been synthesised and evaluated. The highly fluorescent nature of the compounds (up to PhiF = 0.83 in DMSO and 0.38 in aqueous buffer) makes them ideally suited for cellular imaging and visualisation of their cytoplasmic localisation was readily accomplished. Whole organism imaging in zebrafish confirmed both the vascular localisation of the new inhibitors and the impact of HDAC6 inhibition on in vivo development. Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 423146-25-2 Reference：
Isoquinoline – Wikipedia,
Isoquinoline | C9H4103N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Article, the author is Fleming, Cassandra L. and a compound is mentioned, 423146-25-2, 6-(6-Morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)hexanoic acid, introducing its new discovery. 423146-25-2

A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging

Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify ‘profluorogenic’ substrates for intracellular studies.

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Reference£º
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem