Category: 5961-59-1

Ece, Hamdiye published the artcileSilyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives, Quality Control of 5961-59-1, the main research area is aryloxindole preparation; diethyl phosphate Friedel Crafts cyclization trimethylsilyl tricyanopalladate complex catalyst.

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc)2. Wide varieties of di-Et phosphates derived from N-arylmandelamides were converted almost quant. into oxindoles. When N,N-dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Synlett published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lin, Weiwei published the artcileSelective N-Methylation of N-Methylaniline with CO2 and H2 over TiO2-Supported PdZn Catalyst, Related Products of isoquinoline, the main research area is methylation methylaniline carbon dioxide titania supported palladium zinc catalyst.

A series of Pd-ZnO/TiO2, Pd/TiO2, and Pd/ZnO catalysts were synthesized and investigated for N-methylation of N-methylaniline (MA) to N,N-dimethylaniline (DMA) with CO2 and H2. A high performance was observed with a Pd-ZnO/TiO2 catalyst, with 99.9% DMA selectivity at 94% MA conversion. By contrast, both Pd/TiO2 and Pd/ZnO were less active and/or selective. The catalytic performance of Pd-ZnO/TiO2 largely depended on reduction temperature and ZnO loading. The rates for MA conversion (rateMA) and DMA production (rateDMA) increased linearly with the amount of PdZn alloy formed. The reaction was likely to take place via intermediates of N-methylformanilide (MFA) and formate. Formate was produced through the reduction of CO2 with H2 as confirmed by in situ diffuse reflectance Fourier transform IR spectroscopy and then added to MA producing MFA, and finally, MFA was subsequently adsorbed and hydrogenated to DMA. All these steps were promoted by the PdZn alloy. The hydrogenation of MFA to DMA was much faster than the N-methylation of MA to MFA; DMA was stable, so the selectivity to DMA was almost 100% over the Pd-ZnO/TiO2 catalyst.

ACS Catalysis published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yao, Wubing published the artcileSodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines, Quality Control of 5961-59-1, the main research area is secondary tertiary amine preparation; tertiary amide reduction sodium triethylborohydride catalyst.

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hu, Sha published the artcileTfOH-Catalyzed N-H Insertion of α-Substituted-α-Diazoesters with Anilines Provides Access to Unnatural α-Amino Esters, COA of Formula: C8H11NO, the main research area is alpha amino ester preparation regioselective chemoselective; diazoester aniline insertion triflic acid catalyst.

A time-economical TfOH-catalyzed N-H insertion between anilines and α-alkyl and α-aryl-α-diazoacetates provides a straightforward approach to access unnatural α-amino esters, which readily underwent various transformations and can thus be used for the synthesis of pharmaceutically relevant mols. The α-amino esters were obtained in moderate to excellent yields.

Journal of Organic Chemistry published new progress about Amino esters Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jia, Shikun published the artcileTrapping of Zwitterionic Intermediates by Isatins and Imines: Synthesis of Benzoxazines Bearing a C4-Quaternary Stereocenter, Computed Properties of 5961-59-1, the main research area is benzoxazine preparation zwitterion intermediate isatin imine.

Benzoxazines bearing a C4-quaternary stereocenter were accomplished via the rhodium-catalyzed electrophilic trapping of zwitterionic intermediates by isatins and imines, resp. The key intermediates of the strategy are proposed to generate from the reaction of donor-acceptor rhodium carbenes with secondary amides. Usage of chiral BINOL-phosphoric acid co-catalyst resulted in enrichment of enantioselectivity in the trapping process with imines.

Organic Letters published new progress about Benzoxazines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sarki, Naina published the artcileSimple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol, Computed Properties of 5961-59-1, the main research area is amine preparation methylation; nitroarene transfer hydrogenation RuCl3 catalyst.

Methanol is a potential hydrogen source and C1 synthon, which finds interesting applications in both chem. synthesis and energy technologies. The effective utilization of this simple alc. in organic synthesis is of central importance and attracts scientific interest. Herein, a clean and cost-competitive method with the use of methanol as both C1 synthon and H2 source for selective N-methylation of amines by employing relatively cheap RuCl3.xH2O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e.g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chems., highlighting synthetic value of this advanced N-methylation reaction. Using this platform, also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H2-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug mols. (e.g., benzocaine and butamben) as well as key pharmaceutical intermediates. Further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

ChemCatChem published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jamil, A. R. Md. published the artcileN-Methylation of amines and nitroarenes with methanol using heterogeneous platinum catalysts, HPLC of Formula: 5961-59-1, the main research area is amine nitroarene methylation methanol heterogeneous platinum catalysis.

Herein the selective N-methylation of amines and nitroarenes with methanol under basic conditions using carbon-supported Pt nanoparticles (Pt/C) as a heterogeneous catalyst was reported. This method is widely applicable to four types of N-methylation reactions: (1) N,N-dimethylation of aliphatic amines under N2, (2) N-monomethylation of aliphatic amines under 40 bar H2, (3) N-monomethylation of aromatic amines under N2, and (4) tandem synthesis of N-Me anilines from nitroarenes and methanol under 2 bar H2. All these reactions under the same catalytic system showed high yields of the corresponding methylamines for a wide range of substrates, high turnover number (TON), and good catalyst reusability. Mechanistic studies suggested that the reaction proceeded via a borrowing hydrogen methodol. Kinetic results combined with d. functional theory (DFT) calculations revealed that the high performance of Pt/C was ascribed to the moderate metal-hydrogen bond strength of Pt.

Journal of Catalysis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kumar, Arun published the artcileCatalyst free N-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2 using NaBH4, Category: isoquinoline, the main research area is aromatic aliphatic amine formylation sodium borohydride carbon dioxide.

Herein, a sustainable approach for N-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas is reported. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2 with sodium borohydride generates formoxy borohydride species in situ, as confirmed by 1H and 11B NMR spectroscopy. The in situ formation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of the N-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2 with amine leading to N-formylation of amines.

RSC Advances published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Yangsen published the artcilePhotocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride, Product Details of C8H11NO, the main research area is photocatalytic water splitting coupled alkanol oxidation; nitrogen alkylation palladium carbon nitride catalyst green chem; N-alkylation reaction; alkanol oxidation; carbon nitride; photocatalysis; water splitting.

Photocatalytic water splitting technol. (PWST) enables the direct use of water as appealing “”liquid hydrogen source”” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technol. highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chems. and pharmaceuticals from nitroarenes and amines with water and alkanols.

ChemSusChem published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Braun, Carolin published the artcilePlanar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation, HPLC of Formula: 5961-59-1, the main research area is planar chiral paracyclophane pyridonate ligand tantalum catalyzed hydroaminoalkylation.

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (internal). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem