Category: 5961-59-1

Rosien, Michael published the artcileTitanium-Catalyzed Hydroaminoalkylation of Ethylene, Application of 4-Methoxy-N-methylaniline, the main research area is amine preparation; secondary amine ethylene hydroaminoalkylation titanium catalyst; amination; amines; ethylene; hydroaminoalkylation; titanium.

The first examples of titanium-catalyzed hydroaminoalkylation reactions of ethylene with secondary amines such as N-ethylaniline, N-methylcyclohexanamine, pyrrolidine, etc. are presented. The reactions can be achieved with various titanium catalysts and they do not require the use of high pressure equipment. In addition, the first solid-state structure of titanapyrrolidine I (R = H, Cl, Me; n = 2) that is formed by insertion of alkene into the Ti-C bond of titanaaziridine I (n = 1) is reported.

Chemistry – A European Journal published new progress about Aliphatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Liang published the artcileTandem trifluoromethylthiolation and cyclization of N-aryl-3-butenamides with AgSCF3: divergent access to CF3S-substituted 3,4-dihydroquinolin-2-ones and azaspiro[4,5]dienones, Quality Control of 5961-59-1, the main research area is quinolinone dihydro preparation; spiro cyclohexadienone pyrrolidinone preparation; butenamide aryl divergent trifluoromethylthiolation cyclization silver trifluoromethanethiolate.

An AgSCF3-mediated tandem trifluoromethylthiolation and cyclization of N-aryl-3-butenamides I (R1 = H, 2-F, 4-F3C, 3-Cl, 3,4-benzo, etc.; R2 = Me, PhCH2) has been developed. It showed divergent reactivities and enabled the selective syntheses of CF3S-substituted 3,4-dihydroquinolin-2-ones II and azaspiro[4,5]dienones III. The selectivity was achieved through different cyclization pathways of a CF3S-substituted alkyl radical intermediate. This method provides a useful tool for the synthesis of CF3S-substituted N-heterocyclic compounds

Organic Chemistry Frontiers published new progress about Alkadienones Role: SPN (Synthetic Preparation), PREP (Preparation) (cyclic). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Reed-Berendt, Benjamin G. published the artcileManganese-Catalyzed One-Pot Conversion of Nitroarenes into N-Methylarylamines Using Methanol, Related Products of isoquinoline, the main research area is methyl arylamine preparation; nitroarene methanol transfer hydrogenation condensation manganese catalyst.

A manganese-catalyzed one-pot conversion of nitroarenes into N-methylarylamines has been developed. This transfer hydrogenation method employs a well-defined bench stable Mn PN3P pincer precatalyst in combination with methanol as both the reductant and the C1 source. A selection of com. available nitroarenes was converted into N-methylarylamines in synthetically useful yields.

European Journal of Organic Chemistry published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Lin published the artcilePalladium-Catalyzed Methylation of Nitroarenes with Methanol, Synthetic Route of 5961-59-1, the main research area is nitroarene methanol green imidazole monophosphine palladium catalyst chemoselective methylation; methyl arylamine preparation; N-methylation; functionalization; methanol; monophosphines; reaction mechanism.

A procedure for the synthesis of N-methyl-arylamines directly from nitroarenes using methanol as green methylating agent was developed. The key to success is the use of a specific catalyst system consisting of palladium acetate and the ligand 1-[2,6-bis(isopropyl)phenyl]-2-[tert-butyl(2-pyridinyl)phosphino]-1H-Imidazole (I). The generality of this protocol is demonstrated in the synthesis of more than 20 N-methyl-arylamines under comparably mild conditions. Combining this novel methodol. with subsequent coupling processes using the same catalyst allows for efficient diversification of aromatic nitro compounds to a broad variety of amines including drug mols.

Angewandte Chemie, International Edition published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hirai, Takahiro published the artcileEsterification of Tertiary Amides: Remarkable Additive Effects of Potassium Alkoxides for Generating Hetero Manganese-Potassium Dinuclear Active Species, Quality Control of 5961-59-1, the main research area is esterification tertiary amide potassium alkoxide manganese dinuclear catalyst; amides; esterification; manganese; reaction intermediates; reaction mechanisms.

A catalyst system of mononuclear manganese precursor combined with potassium alkoxide served as a superior catalyst compared with our previously reported manganese homodinuclear catalyst (defined within) for esterification of not only tertiary aryl amides, but also tertiary aliphatic amides. On the basis of stoichiometric reactions of a manganese precursor and potassium alkoxide salt, kinetic studies, and d. functional theory (DFT) calculations, we clarified a plausible reaction mechanism in which in situ generated manganese-potassium heterodinuclear species cooperatively activates the carbonyl moiety of the amide and the OH moiety of the alcs. We also revealed details of the reaction mechanism of our previous manganese homodinuclear system, and we found that the activation free energy (ΔG≠) for the manganese-potassium heterodinuclear complex catalyzed esterification of amides is lower than that for the manganese homodinuclear system, which was consistent with the exptl. results. We further applied our catalyst system to deprotect the acetyl moiety of primary and secondary amines.

Chemistry – A European Journal published new progress about Amides, aliphatic Role: RCT (Reactant), RACT (Reactant or Reagent) (tertiary). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhen, Long published the artcileSynthesis of Thiocarbamoyl Fluorides and Isothiocyanates Using CF3SiMe3 and Elemental Sulfur or AgSCF3 and KBr with Amines, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is thiocarbamoyl fluoride isothiocyanate preparation amine sulfur trifluoromethyl trimethylsilane.

Reactions of thiocarbonyl fluoride derived from cheap, readily available, and widely used CF3SiMe3, elemental sulfur, and KF with secondary amines and primary amines at room temperature in THF provided a wide variety of thiocarbamoyl fluorides and isothiocyanates in moderate to excellent yields, resp. The two reactions show broad substrate scope and good functional group tolerance. Moreover, AgSCF3 reacts with secondary/primary amines under KBr at room temperature, affording quant. thiocarbamoyl fluorides/isothiocyanates, which feature late-stage application.

Organic Letters published new progress about Fluorides Role: SPN (Synthetic Preparation), PREP (Preparation) (thiocarbamoyl). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Yanru published the artcileNonmetal-catalyzed hydroamination of ynamides with amines, Application In Synthesis of 5961-59-1, the main research area is alkylamino phenylimine preparation; aniline ynamide triflic acid catalyst regioselective hydroamination; alkenyl diamine preparation; secondary amine ynamide triflic acid catalyst regioselective diastereoselective hydroamination.

The first metal-free catalytic regioselective hydroamination of ynamides with primary and secondary amines were achieved by using TfOH as the catalyst under mild reaction conditions. This appealing strategy provided the corresponding N-arylimines and ethene-1,1-diamines in good to excellent yields with wide functional group tolerance. Furthermore, their applications in 2-aminoindole synthesis was presented.

Organic Chemistry Frontiers published new progress about Alkenes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application In Synthesis of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vytla, Devaiah published the artcileVisible-Light-Promoted Radical Cyclization of N-Arylvinylsulfonamides: Synthesis of CF3/CHF2/CH2CF3-Containing 1,3-Dihydrobenzo[c]isothiazole 2,2-Dioxide Derivatives, Safety of 4-Methoxy-N-methylaniline, the main research area is trifluoromethyl dihydrobenzoisothiazole dioxide preparation; arylvinylsulfonamide visible light promoted radical cyclization.

A photocatalyzed and highly efficient trifluoromethylation of N-arylvinylsulfonamides using com. available CF3SO2Cl as the trifluoromethyl radical source under blue LEDs is reported. The reaction proceeds through radical cyclization under mild conditions. An investigation of the substrate scope is performed to establish a general, synthetically useful protocol for the synthesis of novel trifluoromethylated 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides in moderate to high yields. This method is also successfully applied for the synthesis of difluoromethylated and trifluoroethylated 1,3-dihydrobenzo[c]isothiazole 2,2-dioxides in good to excellent yields.

Synthesis published new progress about Benzisothiazoles Role: SPN (Synthetic Preparation), PREP (Preparation) (dioxides). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ji, Wangqin published the artcileCopper-catalyzed cyclization reaction: synthesis of trifluoromethylated indolinyl ketones, Quality Control of 5961-59-1, the main research area is aryl fluorobutenone alkylaniline copper catalyst diastereoselective cyclization; aroyl fluoroalkyl alkylindole preparation.

A novel, simple, effective and rapid synthetic method to construct the C-2 trifluoromethylated indolinyl ketones via a copper-catalyzed cyclization reaction between N-alkylanilines and β-(trifluoromethyl)-α,β-unsaturated enones was developed. The results of the control experiments showed that the reaction may involve a radical mechanism by a single-electron transfer process. Moreover, a broad substrate scope and good functional groups, high diastereoselectivities (dr, up to >20 : 1) as well as gram-scale synthesis make this approach highly attractive.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aryl ketones Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ruijten, Dieter published the artcileHydrogen Borrowing: towards Aliphatic Tertiary Amines from Lignin Model Compounds Using a Supported Copper Catalyst, Product Details of C8H11NO, the main research area is amine aliphatic tertiary preparation; benzenepropanol amination secondary amine copper zirconium oxide lignin model; Amination; Heterogeneous catalysis; Hydrogen transfer; Lignin; tertiary amines.

Upcoming biorefineries, such as lignin-first, provide renewable aromatics containing unique aliphatic alcs. In this context, a Cu-ZrO2 catalyzed hydrogen borrowing approach was established to yield tertiary amine from the lignin model monomer 3-(3,4-dimethoxyphenyl)-1-propanol and the actual lignin-derived monomers, 3-(4-hydroxyphenyl)-1-propanol and dihydroconiferyl alc., with dimethylamine. Various industrial metal catalysts were evaluated, resulting in nearly quant. mass balances for most catalysts. Identified intermediates, side and reaction products were placed into a corresponding reaction network, supported by kinetic evolution experiments Cu-ZrO2 was selected as the most suitable catalyst combining high alc. conversion with respectable aliphatic tertiary amine selectivity. Low pressure H2 was key for high catalyst activity and tertiary amine selectivity, mainly by hindering undesired reactant dimethylamine disproportionation and alc. amidation. Besides dimethylamine model, diverse secondary amine reactants were tested with moderate to high tertiary amine yields. As most active catalytic site, highly dispersed Cu species in strong contact with ZrO2 is suggested. ToF-SIMS, N2O chemisorption, TGA and XPS of spent Cu-ZrO2 revealed that imperfect amine product desorption and declining surface Cu lowered the catalytic activity upon catalyst reuse, while thermal reduction readily restored the initial activity and selectivity demonstrating catalyst reuse.

ChemSusChem published new progress about Aliphatic amines, secondary amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem