Category: 69454-42-8

Analyzing the synthesis route of 69454-42-8

The synthetic route of 69454-42-8 has been constantly updated, and we look forward to future research findings.

69454-42-8, Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,69454-42-8

Step B: A mixture of methyl l-oxo-l,2-dihydroisoquinoline-3-carboxylate (2.03 g, 10 mmol) and IN HCl/EtOH (20 mL) was stirred at 100 C for 3 h. The mixture was cooled to rt, concentrated under reduced pressure, and adjusted to pH 7 with aq sodium hydrogen carbonate. The mixture was then extracted with EtOAc and the combined organic layers were dried over Na2S04j filtered, and concentrated under reduced pressure to afford ethyl l-oxo-l,2-dihydroisoquinoline-3-carboxylate as a tan solid (1.8 g, 83%). 1H NMR (400 MHz, DMSO-d6) delta 11.19 (s, 1H), 8.26 (d, J= 8.0Hz, 1H), 7.92 (d, J= 8.0 Hz, 1H), 7.79-7.73 (m, 1H), 7.66-7.68 (m, 1H), 7.44 (s, 1H), 4.36 (q, J= 7.2 Hz, 2H), 1.36 (t, J= 7.2 Hz, 3H); LC-MS (ESI) m/z 218 (M+H)+

The synthetic route of 69454-42-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMBIT BIOSCIENCES CORPORATION; FARAONI, Raffaella; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin; SETTI, Eduardo; WO2012/30944; (2012); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Some tips on 69454-42-8

69454-42-8 Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 641183, aisoquinoline compound, is more and more widely used in various.

69454-42-8, Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Synthesis of methyl 4-chloroisoquinoline-2-carboxylate: Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate (0.68g, 3.3mmoles) was dissolved in excess phosphorus oxy chloride (5 mis) and the clear solution heated (950C) for 3 hours and overnight at room temperature. The reaction was diluted with toluene (10mIs) and azeotroped twice. The residual oil was diluted with dichloromethane (10mls) and quenched with ice cooled water (50mIs). Further dichloromethane was added (15mls) and the layers separated. The aqueous layer was extracted with dichloromethane (10mIs) and the dichloromethane phases combined and washed with saturated sodium bicarbonate (10mIs), water (10mIs) and brine (10mIs). After drying over magnesium sulphate the solution was filtered and concentrated to give an off white solid. (0.47g, 64% yield).

69454-42-8 Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 641183, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; QUEEN MARY AND WESTFIELD COLLEGE; COTTER, Finbarr, Edward; WO2010/125343; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem