69454-42-8, Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Synthesis of methyl 4-chloroisoquinoline-2-carboxylate: Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate (0.68g, 3.3mmoles) was dissolved in excess phosphorus oxy chloride (5 mis) and the clear solution heated (950C) for 3 hours and overnight at room temperature. The reaction was diluted with toluene (10mIs) and azeotroped twice. The residual oil was diluted with dichloromethane (10mls) and quenched with ice cooled water (50mIs). Further dichloromethane was added (15mls) and the layers separated. The aqueous layer was extracted with dichloromethane (10mIs) and the dichloromethane phases combined and washed with saturated sodium bicarbonate (10mIs), water (10mIs) and brine (10mIs). After drying over magnesium sulphate the solution was filtered and concentrated to give an off white solid. (0.47g, 64% yield).
69454-42-8 Methyl 1-oxo-1,2-dihydroisoquinoline-3-carboxylate 641183, aisoquinoline compound, is more and more widely used in various.
Reference£º
Patent; QUEEN MARY AND WESTFIELD COLLEGE; COTTER, Finbarr, Edward; WO2010/125343; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem