Category: 74904-29-3

On November 22, 2017, Fish, Inbar; Stossel, Anne; Eitel, Katrin; Valant, Celine; Albold, Sabine; Huebner, Harald; Moller, Dorothee; Clark, Mary J.; Sunahara, Roger K.; Christopoulos, Arthur; Shoichet, Brian K.; Gmeiner, Peter published an article.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the article was Structure-Based Design and Discovery of New M2 Receptor Agonists. And the article contained the following:

Muscarinic receptor agonists are characterized by apparently strict restraints on their tertiary or quaternary amine and their distance to an ester or related center. On the basis of the active state crystal structure of the muscarinic M2 receptor in complex with iperoxo, the authors explored potential agonists that lacked the highly conserved functionalities of previously known ligands. Using structure-guided pharmacophore design followed by docking, the authors found two agonists (compounds 3 (2-(3-methoxyphenyl)-N,N,N-trimethylethan-1-aminium formate) and 17 (2-(benzofuran-6-yl)-N,N,N-trimethylethan-1-aminium formate)), out of 19 docked and synthesized compounds, that fit the receptor well and were predicted to form a hydrogen-bond conserved among known agonists. Structural optimization led to compound 28 (2-(2,3-dihydrobenzofuran-6-yl)-N,N,N-trimethylethan-1-aminium formate), which was 4-fold more potent than its parent 3. Fortified by the discovery of this new scaffold, the authors sought a broader range of chemotypes by docking 2.2 million fragments, which revealed another three micromolar agonists unrelated either to 28 or known muscarinics. Even pockets as tightly defined and as deeply studied as that of the muscarinic reveal opportunities for the structure-based design and the discovery of new chemotypes. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to muscarinic m2 receptor agonist structure based design preparation docking, Pharmacology: Structure-Activity and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Alvarez, M.; Joule, J. A. published an article in 2005, the title of the article was Product class 6: isoquinolinones.Quality Control of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:

A review primarily covering methods of preparation of 1(2H)-isoquinolinones and 3(2H)-isoquinolinones. Synthetic methods include cyclization, ring transformation, and substituent modification. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Quality Control of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to review isoquinolinone preparation cyclization ring transformation, Heterocyclic Compounds (One Hetero Atom): Reviews and other aspects.Quality Control of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On April 1, 2004, Blanco-Pillado, Maria-Jesus; Chappell, Mark Donald; Garcia De la Torre, Marta; Diaz Buezo, Nuria; Fritz, James Erwin; Holloway, William Glen; Matt, James Edward, Jr.; Mitch, Charles Howard; Pedregal-Tercero, Concepcion; Quimby, Steven James; Siegel, Miles Goodman; Smith, Dana Rae; Stucky, Russell Dean; Takeuchi, Kumiko; Thomas, Elizabeth Marie; Wolfe, Chad Nolan published a patent.Reference of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the patent was Preparation of [[(aminoalkyl)aryl]oxy]nicotinamides and analogs as opioid receptor antagonist for treatment of obesity and related conditions. And the patent contained the following:

Title diaryl ethers I [wherein X1-X10 = independently C, CH, or N; provided that each of rings A or B has no more than 2 N atoms; E = O or NH; R1 and R2 = independently H or (un)substituted (cyclo)alkyl, alkenyl, alkynyl, (alkyl)aryl, (aryl)heterocyclyl, (cyclo)alkylheterocyclyl, (cyclo)alkanoylalkyl, aroylalkyl, aryloxyalkyl, benzhydryl, bicyclyl(alkyl), benzoyl(alkyl), alkoxyalkyl, alkoxycarbonyl, (aryl)alkylsulfonyl, heterocyclylalkylsulfonyl, cycloalkylalkyl, carboxyalkyl, carbamoylalkyl, etc.; R3 and R3′ = independently H, alkyl, alkenyl, alkynyl, (alkyl)aryl, or alkylcycloalkyl; R4 and R5 = independently H, (halo)alkyl, alkenyl, alkynyl, alkoxy(halo)alkyl, thioalkyl, halo, aryl(alkyl), alkanoyl, alkoxycarbonyl, aminoalkyl, cycloalkylalkyl, etc.; R6 and R7 = independently H, (cyclo)alkyl, alkenyl, alkynyl, alkanoyl, OH, alkoxy, (aryl)alkylsulfonyl, heterocyclylalkylsulfonyl, aryl(alkyl), carbamoyl(alkyl), etc.; m = 1-3; n = 0-3; p = 0-3; or pharmaceutically acceptable salts, solvates, enantiomers, racemates, diastereomers, or mixtures thereof] were prepared as μ-, κ-, and δ-opioid receptor antagonists. For example, reductive amination of 6-(2-fluoro-4-formylphenoxy)nicotinamide and 3-methylbutylamine provided II (99%). The latter inhibited ex vivo binding of [3H]-diprenorphine in rat striatum/nucleus accumbens by >65% at a concentration of 7 mg/kg. In an acute feeding rat obesity assay, II suppressed opioid receptors at a dose of 0.3 μg/kg. In addition, diet-induced obese rats achieved an energy balance (caloric intake minus utilization) of -81 kcal/kg/day upon administration of 0.3 mg/kg p.o. of II in an indirect calorimetry assay. Thus, I and their pharmaceutical compositions are useful for the treatment, prevention, or amelioration of obesity and related diseases. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Reference of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to aryloxy nicotinamide preparation opioid receptor antagonist antiobesity, aryl heteroaryl ether preparation opioid receptor antagonist antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Reference of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On December 31, 1993, Shanker, P. Sathya; Rao, G. S. R. Subba published an article.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the article was Synthesis of isoquinolines from indanones: total synthesis of illudinine. And the article contained the following:

Schmidt reaction of 5-methoxy or 7-methoxyindan-1-ones or their derivatives results exclusively in isocarbostyrils which are converted into 6-methoxy or 8-methoxyisoquinolines in good yields. This strategy has been extended to the total synthesis of illudinine Me ester (I) starting from hexahydroindacenecarboxylate II. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to schmidt reaction methoxyindanone, amination ring expansion methoxyindanone, isoquinolinone tetrahydro, illudinine, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 28, 2022, Gu, Qiong; Xu, Jun; Fang, Yuying published a patent.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one The title of the patent was Process for preparation of benzimidazole compound and application thereof in preparation of ferroptosis inhibitor. And the patent contained the following:

The invention relates to preparation of a benzimidazole compound, and an application thereof in preparation of a ferroptosis inhibitor. The benzimidazole compound has a structure as shown in formula I or II. According to the benzimidazole compound provided by the present invention, a lipophilic group is introduced to an R1 position, and a specific group is introduced to an R2 position, such that the obtained compound has relatively good ferroptosis inhibitory activity and can be used as a lead compound for preventing and treating nervous system diseases such as stroke. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to benzimidazole compound preparation ferroptosis inhibitory, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kurouchi, Hiroaki; Otani, Yuko; Ohwada, Tomohiko published an article in 2016, the title of the article was Facile synthesis of 5- to 7-membered benzolactam compounds via strongly facilitated electrophilic aromtic substitution reaction.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:

Activation of aromatic ring-tethered carbamate compounds with trifluoromethanesulfonic acid to obtain benzolactams with 5- to 7-membered rings and examined the substrate scope and limitations of this activation method. In 5-membered ring formation, a halogen group on the aromatic ring did not greatly affect the reaction yield, but other electron-donating groups inhibited the cyclization reaction and various side-reactions occurred. In 7-membered ring formation, eletron-donating groups on aromatic ring promoted the cyclization reaction but cyclization of electron-deficient aromatic rings did not proceed well. The 6-membered ring formation reaction showed the greatest substrate generality. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to aralkylcarbamoyloxy benzoate preparation triflic acid promoter electrophilic aromatic substitution, benzolactam preparation, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Recommanded Product: 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On August 13, 2020, Milan, David J. published a patent.Related Products of 74904-29-3 The title of the patent was Treating long QT syndrome. And the patent contained the following:

This document relates to compounds useful for treating and preventing disorders associated with long QT syndrome such as cardiac arrhythmia, ventricular arrhythmia, hypertrophic cardiomyopathy, and congestive heart failure. Also provided herein are methods and materials for using such compounds to shorten myocardial repolarization time in a patient. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Related Products of 74904-29-3

The Article related to myocardial repolarization long qt syndrome therapy heart failure arrhythmia, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.Related Products of 74904-29-3

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On March 31, 1980, Umezawa, Bunsuke; Hoshino, Osamu; Sawaki, Shohei; Mori, Kazuhiko published an article.Computed Properties of 74904-29-3 The title of the article was A cyclization of β-arylethylisocyanates to 3,4-dihydroisocarbostyrils. And the article contained the following:

Isocyanates derived from I (R1 = R4 = H, R2R3 = OCH2O, R2 = R3 = MeO, R2 = MeO, R3 = PhCH2O, R2 = PhCH2O, R3 = MeO; R1 = H, R2 = R3 = R4 = MeO; R1 = HO, R2 = MeO, R3 = HO, R4 = PhCH2; R1 = PhCH2, R2 = HO, R3 = MeO, R4 = H) cyclized on treatment with phosphoric acid to give the dihydroisocarbostyrils II. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Computed Properties of 74904-29-3

The Article related to isocarbostyril dihydro, phenethyl isocyanate cyclization, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Computed Properties of 74904-29-3

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In, Jinkyung; Hwang, Soonho; Kim, Changhun; Seo, Jae Hong; Kim, Sanghee published an article in 2013, the title of the article was Synthesis of 3,4-Dihydroisoquinolin-1-ones from N-Boc-(β-Arylethyl)carbamates via Isocyanate Intermediates.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one And the article contains the following content:

Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl)carbamates are described. The reactions involved the use of Tf2O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF3·Et2O, to enhance the Friedel-Crafts-type cyclization of the isocyanate intermediates. This method allowed the synthesis of various substituted isoquinolin-1-ones, β-carbolines, thiophene-fused ring systems and tetrahydrobenzoazepin-1-ones in good yields and with high regioselectivities. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

The Article related to dihydroisoquinolinone synthesis arylethylcarbamate isocyanate intermediate cyclization, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.Safety of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

On July 1, 2006, Jesudason, Cynthia D.; Beavers, Lisa S.; Cramer, Jeffrey W.; Dill, Joelle; Finley, Don R.; Lindsley, Craig W.; Stevens, F. Craig; Gadski, Robert A.; Oldham, Samuel W.; Pickard, R. Todd; Siedem, Christopher S.; Sindelar, Dana K.; Singh, Ajay; Watson, Brian M.; Hipskind, Philip A. published an article.COA of Formula: C10H11NO2 The title of the article was Synthesis and SAR of novel histamine H3 receptor antagonists. And the article contained the following:

The synthesis and biol. evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H3 receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H3 receptors are reported. The experimental process involved the reaction of 8-Methoxy-3,4-dihydroisoquinolin-1(2H)-one(cas: 74904-29-3).COA of Formula: C10H11NO2

The Article related to h3 antihistaminic tetrahydroisoquinoline tetrahydroquinoline tetrahydroazepine preparation, Heterocyclic Compounds (One Hetero Atom): Quinolines and Isoquinolines and other aspects.COA of Formula: C10H11NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem