Category: 75476-83-4

Synthesis and broad antiviral activity of novel 2-aryl-isoindolin-1-ones towards diverse enterovirus A71 clinical isolates was written by Wang, Yixuan;Wang, Huiqiang;Jiang, Xinbei;Jiang, Zhi;Guo, Tingting;Ji, Xingyue;Li, Yanping;Li, Yuhuan;Li, Zhuorong. And the article was included in Molecules in 2019.Formula: C9H6IN The following contents are mentioned in the article:

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and investigated for their in vitro antiviral activity towards multiple EV-A71 clin. isolates (H, BrCr, Shenzhen98, Jiangsu52) in Vero cell culture in this study. The structure-activity relationship (SAR) studies identified 2-phenyl-isoindolin-1-ones as a new potent chemotype with potent antiviral activity against EV-A71. Ten out of the 24 tested compounds showed significant antiviral activity (EC50 < 10 muM) towards four EV-A71 strains. Compounds A3 and A4 exhibited broad and potent antiviral activity with the 50% effective concentration (EC50) values in the range of 1.23-1.76 muM. Moreover, the selectivity indexes of A3 and A4 were significantly higher than those of the reference compound, pirodavir. The western blotting experiment indicated that the viral VP1 was significantly decreased at both the protein and RNA level in a dose-dependent manner following treatment with compound A3. Moreover, compound A3 inhibited the viral replication by acting on the virus entry stage. In summary, this study led to the discovery of 2-aryl-isoindolin-1-ones as a promising scaffold with potent anti-EV-A71 activities, which deserves further in-depth studies. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Formula: C9H6IN).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Formula: C9H6IN

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis of cortistatins A, J, K and L was written by Flyer, Alec N.;Si, Chong;Myers, Andrew G.. And the article was included in Nature Chemistry in 2010.Product Details of 75476-83-4 The following contents are mentioned in the article:

The cortistatins are a recently identified class of marine natural products characterized by an unusual steroidal skeleton, which have been found to inhibit differentially the proliferation of various mammalian cells in culture by an unknown mechanism. We describe a comprehensive route for the synthesis of cortistatins from a common precursor, azide I, which in turn is assembled from two fragments of similar structural complexity. Cortistatins A and J, and for the first time K and L, have been synthesized in parallel processes from like intermediates prepared from a single compound With the identification of facile laboratory transformations linking intermediates in the cortistatin L synthetic series with corresponding intermediates to cortistatins A and J, we have been led to speculate that somewhat related paths might occur in nature, offering potential sequencing and chem. detail for cortistatin biosynthetic pathways. The antiproliferative activity of the cortistatins was tested against HUVECs. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Product Details of 75476-83-4).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Other industrial applications include their use as corrosion inhibitors, preservatives, and as solvents for resins and terpenes.Product Details of 75476-83-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis of isoquinolines from indenes was written by Miller, R. Bryan;Frincke, James M.. And the article was included in Journal of Organic Chemistry in 1980.Reference of 75476-83-4 The following contents are mentioned in the article:

A general procedure for the preparation of Me, di-Me, NO₂, Br, iodo, and di-MeO-substituted isoquinolines from the appropriately substituted indenes is described. Ozonolysis of the indenes followed by reductive workup gives intermediate homophthalaldehydes, which are treated with NH₄OH to give the isoquinolines. This “one-pot”, three-step reaction sequence was applied to the formation of all of the mono-C-methyl-substituted isoquinolines in a regiospecific manner. The procedure is applicable to both electron-withdrawing and electron-donating substituents on the indene system. In this manner the 6- and 7-nitro-, -bromo-, and -iodoisoquinolines were prepared This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Reference of 75476-83-4).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Reference of 75476-83-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A was written by Yamashita, Shuji;Kitajima, Kazuki;Iso, Kentaro;Hirama, Masahiro. And the article was included in Tetrahedron Letters in 2009.Synthetic Route of C9H6IN The following contents are mentioned in the article:

The highly stereoselective attachment of isoquinoline onto the steroidal framework of cortistatin A (I) was achieved. The synthetic strategy featured a Ce-mediated nucleophilic addition of an isoquinoline unit to the sterically congested ketone followed by formation of the Ph thiocarbamate, and subsequent stereoselective radical reduction The new method resulted in a formal total synthesis of cortistatin A. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Synthetic Route of C9H6IN).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Synthetic Route of C9H6IN

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Product class 5: isoquinolines was written by Alvarez, M.;Joule, J. A.. And the article was included in Science of Synthesis in 2005.Formula: C9H6IN The following contents are mentioned in the article:

A review primarily covering methods of preparation of isoquinolines via cyclization, ring transformations or substituent modification. Isoquinoline 2-oxides and isoquinolinium salts are also included. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Formula: C9H6IN).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. The Pomeranz–Fritsch reaction provides a method for the preparation of isoquinoline. This reaction uses a benzaldehyde and aminoacetoaldehyde diethyl acetal, which in an acid medium react to form isoquinoline.Formula: C9H6IN

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem